Objective To evaluate the clinical application effect of transparent film dressing in fistula nursing of patients with percutanueous nephrostomy (PCN).Methods By using before-after self control study method,40 patients with pelvic tumor that caused by postrenal renal failure,and needed long-term fistula remained after PCN surgery were selected as the research object.Conventional sterile gauze and tape were used to nurse the fistula before intervention and transparent film dressing was used after intervention.Results Patents always worried about trachea cannula exodus and infection before intervention.After intervention,the comfort degree of their daily life (like showering,sleeping and daily activities) was obviously higher than that before intervention (P＜0.01).The incidence of renal fistula local adverse effect after intervention is relatively low.And the difference was statistically significant (P＜ 0.01).Before intervention,the tape was loosing in (5.47 ± 1.48) days,there were three cases of accidental trachea cannula exodus;and after intervention,transparent film dressing hemmed in (14.22±1.99) days,and no accidental trachea cannula exodus occurred (P＜0.01);and no hyper-sensitive cases happened with the transparent film dressing.Conclusions The transparent film dressing has the advantages of stable viscosity,waterproofing,fungi-proofing,breathability and hypoallergenic,etc.It can well protect and fix the fistula,and it is suitable for nursing care of patients with long-term renal fistula.