Objective To study the clinical features, treatment strategy and prognosis of children and adolescent with spinal bone tumors. Methods Forty-three patients were retrospectively investigated from January 1987 to June 2002, thirty-one of which were male, and the others were female. The age of patients ranged from 3 to 16 years with an average of 11.8 years. The pathological examination suggested that tumor-like conditions were 11 cases (25.6%), benign tumors 13 cases (30.2%), and malignant tumors 19 cases (44.2%). The cervical vertebrae tumors were 15 cases, thoracic vertebrae 16 cases, lumbar vertebrae 6 cases, and sacral vertebrae 6 cases. Treatment included: 1 case of malignant lymphoma was only subjected to chemotherapy; and the others were undertaken tumor resection and bone grafting to fusion with or without internal fixation. All patients of malignant tumors were performed adjuvant radiotherapy or chemotherapy after operation. Results The follow-up period was from 1 to 10 years with an average of 4.3 years. All patients of benign tumors obtained satisfied outcomes with local symptom and neural deficits improved, and no tumor recurrence happened. 6 cases (2 cases of primitive neural ectodermal tumor, 1 case of Ewing's sarcoma, 1 case of neuroblastoma, 1 case of plasma cell sarcoma and 1 case of chondrosarcoma) of malignant patients were died from metastasis and systemic failure, and the ratio was 14% and 31.6% of total and malignant tumor respectively. One case of bone giant cell tumor and 1 case of Schwannoma got recurrence at 2.5 years and 10 months after operation respectively. Conclusion For patients of children and adolescent with spinal bone tumors, the prognosis of the benign is better if tumors were removed radically. However, the patients with malignant tumors had worse prognosis with higher recurrent or death rate, and its prognosis is closely correlated to tumor's characters, operation strategy, and extending postoperative therapy.

Objective To investigate the clinical characteristic, surgical stage, operative approach, resection and stability reconstruction of dumbbell intra-extradural tumor of cervical spine. Methods From January 1999 to December 2005, 37 consecutive cases with cervical dumbbell intra-extradural tumor were retrospectively studied. 18 males and 19 females ranged from 18 to 80 years old were involved in this study, including 25 schwannomas, 3 neurofibromas, 5 multi-neurofibromas and 4 malignant schwannomas. According to tumor location and involved range, all tumors were divided into five stages: 8 cases in Ⅰ stage, 9 cases in Ⅱstage, 13 cases in Ⅲ stage, 5 cases in Ⅳ stage and 2 cases in Ⅴ stage. Resection and reconstruction were performed at 20 patients through posterior-lateral approach, 17 patients through anterior-lateral combined with posterior-lateral approach. Lateral mass screw internal fixation system were used in 26 cases, while anterior combined posterior fixation were performed in 5 cases and none fixation in 6 cases. Results The follow-up period was from 3 months to 7 years. 1 case developed a transient weakening of upper limb, 1 case developed anesthesia in posterior neck, and 1 case developed Horner's sign. Vertebral artery ligation was performed in 1 case because of vertebral artery injury. 2 cases with malignant schwannoma occurred local recurrence in 1-2 years postoperation and received second operation. The recent effects after operation were satisfactory in majority cases,with complete recovery of spinal cord function in 19 cases. 2 cases without fixation appeared recuration deformity in cervical spine in 1-2 years postoperation. Conclusion The surgical approach and operative methods must be selected according to the location, surgical staging, characters of tumors. Stability reconstruction plays important roles in maintaining stability of cervical spine. More care should be taken in procedure for protecting vertebral artery, cervical nerve and spinal cord.

Objective:To investigate the influence of different depression degree status on the clinic symptoms and survival status in the patients with metastasis tumor in spine (MTS). Methods: By using Zung's self rating depression scale (SDS), we studied 125 patients with MTS between 1999 and 2001. Results: It was found that 44% patients with MTS were affected by depression. The survival period in the negative depression group(NDP) was longer than that in the moderate and the severe groups after a mean of 21 months follow up( P

Objective To study the characteristics and regularities of Chinese drugs preparations ADR in order to improve the rational drug use.Methods A total of 112 cases of TCM ADR reports collected in 2009～2011 which have been presented to the Guangzhou ADR Monitoring Center.Results Of the 112 cases,26 kinds of drugs were involved,quinquagenarian were the main crowd,intravenous infusion was the main route of administration,the main types of TCM ADR were lesions of skin and accessories.Conclusion Great importance should be attached to TCM ADR monitoring to promote rational drug use in the clinic.

Purpose To evaluate the carotid artery structure and diastolic function of the brachial artery in children with coarctation of aorta (CoA) using high-frequency ultrasound. Materials and Methods Twenty-four cases of children with CoA were selected, among them seven cases were simple CoA and 17 cases were combined with other cardiac malformations, and 20 cases of simple ventricular septal defect (VSD) children and 20 healthy children over the same period were selected as the control groups. Carotid artery intima-media thickness (IMT) and brachial artery flow-mediated vasodilation (FMD) in all subjects were evaluated using high-frequency ultrasound, vascular structure and functional changes were compared before CoA correction and VSD repair treatment. Results Carotid artery IMT of CoA group was (0.47±0.12) mm, which was significantly larger than the VSD group (0.41±0.10) mm and the control group (0.40±0.09) mm, and the difference was statistically significant (F=4.275, P<0.05); brachial artery FMD [(5.48±1.66)%] of CoA group was significantly lower than that of the VSD group [(6.69± 1.45)%] and the control group [(6.59±1.84)%], and the difference was also statistically significant (F=4.318, P<0.05), but there was no significant difference (q=0.400, 0.191;P>0.05) between the VSD group and the control group for carotid artery IMT and brachial artery FMD. Conclusion In children with CoA, besides the structure abnormalities of the narrowing vascular, there is also the combination of structural and fuctional changes such as carotid artery intima-media complex thickening and brachial artery flow-mediated dilation function decrease.

Objective:To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement(CPC).Methods: Methotrexate(MTX),epirubicin(EPI),hydroxy camptothecin(OH-CPT),and arsenic trioxide(As_2O_3) were incorporated,each in a proportion of 2%,5%,and 8%,into the powder-phase CPC.Untreated CPC was taken as control.The setting time,compression strength,and the microstructure of the resultant products were evaluated and tested.Results: Compared with control group,the setting time was significantly prolonged when 2% EPI was incorporated into CPC(P

Objective To analyze the effect of compound Minwei on serum interleukin-4(IL-4),interferon-γ(IFN-γ)value in children with acute urticaria.Methods in our hospital from March 2015 to October 2016 received 148 cases of children with acute urticaria eczema,were randomly divided into study group and control group,74 cases in each group,study the application of compound chlorphenamine maleate and vitamin syrup for treatment,the control group were applied paeonol ointment treatment,curative effect,evaluation of children with symptoms before and after treatment respectively,and detection serum IL-4 and IFN-levels.Results before treatment,the two groups had no statistical significance with symptom score,serum IL-4,IFN-levels difference(P>0.05);after treatment,the clinical efficacy of the study group,serum IFN-γ levels higher than the control group,the serum level of IL-4 score,symptoms than the control group,the difference has statistical significance(P<0.05).Conclusion acute eczema urticaria children with compound Minwei syrup treatment,can significantly relieve the symptoms of children,improve the body immunity,promote children rehabilitation,has good treatment effect.

Image analysis plays an important role in morphological study of tissues and cells and their quantitative analysis. It also contributes to clinical pathological diagnosis. With the rapid development of computer technology great progress has been made in the image analysis system, its measurement, rapidity, accuracy and the extent of automation have been greatly enhanced. In the meantime advances in medicine give impetus to its improvement. In this paper, the process of development, the basic structure and mechanism of image analysis system are discussed and the application of image analysis system to the study of biomedicinal is presented.
Image Processing, Computer-Assisted ; instrumentation ; methods ; Medicine

Objective To discuss the value of color Doppler echocardiography in diagnosis of scimitar syndrome .Methods The echocardiographic results of 6 patients with a diagnosis of scimitar syndrome were reviewed retrospectively .Their sonographic and hemodynamic characteristics were also analyzed connected with the reports in the literature .Results Three cases had dextrocardia and the others had mesocardia .All cases got right ventricular dimension enlargement .Total or partial of right pulmonary venous connection to the inferior vena cava were 3 cases respectively .All cases had right pulmonary artery hypoplasia .All of 6 cases echocardiographic results were in accordance with the findings by CT angiography and 4 cases were confirmed by operation .Conclusions The sonographic features of scimitar syndrome were obvious ,and echocardiography was contribute to early diagnosis of scimitar syndrome .

Objective To evaluate the effectiveness of one-stage debridement for cervical tuberculosis at different segments.Methods Clinical data of 54 patients (male 20,female 34) with cervical tuberculosis treated by one-stage debridement from Jan 1998 to Dec 2011 were reviewed retrospectively.The average age of these patients was 45.4 years (range,26-75 years).Among them,12 cases were involved in single level (C2 1 case,C4 2 cases,C5 3 cases,C6 4 cases,C7 2 cases); 36 cases in the adjacent two levels (C1,2 3 cases,C2,3 2 cases,C3,4 5 cases,C4,5 6 cases,C5,6 14 cases,C6,7 5 cases,C7T1 1 case); 5 cases in three levels(C4 6 2 cases,C5-7 2 cases,C3,5,6 1 case)and 1 case in four levels (C4-7).Five cases were involved in other spinal levels (T6 1 case,T 3 cases,L3,4 1 case).Comorbidity of cervical ossification of the posterior longitudinal ligament was found in 1 case.Before surgery,the mean VAS and JOA scores were 5.9 (range,4-9) and 10.5 (range,7-12) respectively and the mean Cobb angle of lesion segment was 26.7°± 9.1°.All cases underwent regular anti-TB treatment preoperatively,and surgical treatment were performed when blood sedimentation (ESR) was lower than 50 mm/1 h.According to the segmental involvement,different surgical approaches were performed including anterior debridement with anterior or anterior-posterior internal fixation and fusion,submandibular approach debridement with posterior occipital cervical fusion or atlantoaxial fusion.Results Mean follow-up duration was 27.3 months (range,13-52 months).Symptoms were improved significantly in all cases.Mean time of union was 3.2 months (range,2-4 months).At the last follow-up,the mean VAS and JOA scores were 5.9 (range,4-9)and 10.5 (range,7-12) respectively,and the mean Cobb angle of lesion segment was 6.8°.Regular anti-TB treatment was performed postoperatively for 18 to 20 months.Intraoperative esophageal injury was found in one case of upper cervical tuberculosis which was cured uneventfully after gastrointestinal tubation for 1 week.No cervical tuberculosis recurrence,graft loosening or pseudarthrosis was found in follow-up.Conclusion With preoperative anti-TB treatment,cervical tuberculosis can be treated by one-stage foci debridement according to the segmental involvement and deformity.Postoperative regular anti-TB treatment is a crucial factor for the final recovery of cervical tuberculosis.