Objective To investigate the clinical effect of Shufeng Tongqiao,Yifei Jianpi therapy on persis-tent allergic rhinitis.Methods From January 2014 to February 2015,80 patients with allergic rhinitis in our hospital were chosen.Using random number table,they were randomly divided into control group and treatment group.The con-trol group was given western medicine,the treatment group was given self designed formula on the basis of the control group.The clinical symptoms,the efficacy and related indicators of the two groups before and after treatment were compared.Results After treatment for 3 months and 1 year,the IgE test results in the treatment and control groups were significantly lower than before treatment(t =13.93,14.45,12.11,7.46,all P <0.05),the IgE test results after 1 year of treatment in the treatment group was significantly lower than the control group (t =-4.59,P <0.05).IgE test results in the control group after one year of treatment was significantly higher than treatment for 3 months (t =-2.61,P <0.05 ).The total effective rate of the treatment group was 87.5%,which was significantly higher than 70.0% of the control group(P <0.05 ).Conclusion Shufeng Tongqiao,Yifei Jianpi method in the treatment of persistent allergic rhinitis has significant clinical effect,it can effectively alleviate rhinitis symptoms,stabilize serum IgE levels.

Objective Laser induced fluorescence spectroscopy have been used in early diagnosis of GI cancer, but the device is expensive and inconvenient. The purpose of this study was to test the effectiveness and feasibility of a new device designed by the authors. Methods Two formulas were set up based on the analysis of OMA data and a new system was established. Fifteen samples of normal tissue and 40 cases of endoscopic diagnosed cancer were tested. Results (1) First formula: general energy of fluorescence was W 359～659 nm . (2) The second: the ratio of energy integral was W 359～460 nm /W 460～659 nm . (3) The sensitivity and specificity were 93.3% and 100.0% for 15 samples of gastro intestinal cancer in vitro and were 90.0% and 92.5% respectively for gastrointestinal cancer endoscopically. Conclusions (1) The deviec may help doctors to determine the characteristics of lesion in endoscopy and the efficacy of the instrument was the same as OMA system. (2) The cost was about one tenth of that for OMA system.

Objective To investigate the apoptosis-inducing effect of the Tongbu-Xiaoji decoction on A549 cells.Methods A549 cell lines were cultured with normal serum and different concentration of serum containing Tongbu-Xiaoji decoction.The cells were stained with PI and Annexin V,and were evaluated by flowcytometry.Resnlts A549 cells were treated by Tongbu-Xiaoji decoction with low、median and high dose medicated serum,the rate of apoptosis in 24h were (5.92±2.04)％,(12.57±1.96)％,and (16.51±1.52)％respectively; the rate of apoptosis in 48h were (13.15±1.60)％,(26.42±2.30)％,and (31.47±2.08)％respectively and the rate of apoptosis in 72 h were (18.73 ± 1.89) ％,(31.72± 1.99) ％,and (36.92± 1.38) ％respectively,all were lower than compared with the model control group in 24 h were (0.40±0.08)％,48 h were (0.58± 0.16)％,72 h were (0.85 ± 0.13)％.Conclusion Tongbu-Xiaoji decoction has the apoptosis-inducing effect on A549 cells.

Objective To evaluate the clinical effect in prevention of intravenous catheter-related infection(CRI) using antiseptic impregnated central venous catheter.Methods Intravenous catheter-related infection was retrospectively analyzed between 440 cases performed with general centrol venous catheter and 420 cases performed with antiseptic impregnated central venous catheter in ICU.Results There were 34 cases of CRI in 860 cases,28 cases were inserted general central venous catheter and 6 cases inserted antiseptic impregnated central venous catheter,the group of antiseptic impregnated was lower singificantly than the group of general in infection rate(P=0.0002).Conclusion Using antiseptic impregnated central venous catheter can reduce CRI,which has clinical effect in prevention of CRI.

Objective To evaluate the diagnostic value of ultrasound-guided pleural biopsy combined with thoracic biochemical detections in malignant and tuberculous pleural effusions. Methods Sixty-four patients with moderate or large pleural effusions and pleural thickening received the ultrasound-guided diagnostic pleural biopsy. All patients had chest CT enhancement scans to find out the suspicious pleural thickening preoperatively, facilitating the selection of puncture sites by ultrasound. Pleural tissue samples were sent for pathological examinations immediately. After successful achievements of pleural biopsy, ultrasound-guided aspiration or drainage was performed to alleviate symptoms, more importantly, to get pleural effusions for biochemical analysis. Biological results including carcinoembryonic antigen(CEA), CA125, CYFRA21 and lactate dehydrogenase(LDH) in malignant and tuberculous effusions were analyzed by group design t tests. The positive rates of CEA, CA125, CYFRA21, LDH in malignant and tuberculous effusions were compared by chi square tests. Results Pleural tissues in all cases were got by one pleural biopsy procedure. The strategy of pleural biopsy we used in this study had a successful rate reaching 100%(64/64), and 73% (46/64) patients had a definitive diagnosis as malignant or tuberculous effusion. Twenty-seven cases were diagnosed as malignant effusions and thirty-seven cases as tuberculous effusions based on the deifnitive clinical diagnosis. The positive rates of CEA, CA125, CYFRA21, LDH in malignant effusions were 100%(27/27), 100%(27/27), 100%(27/27), 89%(24/27) respectively, and 0%(0/37), 84%(31/37), 78%(29/37), 76%(28/37) respectively in tuberculous effusions. The positive rate of CEA between malignant and tuberculous effusions differed signiifcantly (χ2=64.0, P < 0.01), so did CA125 (χ2=3.1, P < 0.01) and CYFRA21(χ2=4.8, P<0.01). The average levels of CEA, CA125, CYFRA21, LDH in pleural effusion were (727.1±658.8)μg/L, (795.2±1249.6)×103 U/L, (296.2±320.7)μg/L, (1077.9±1058.5) U/L respectively, and (1.7±1.1)μg/L, (336.3±208.6)×103 U/L, (20.7±14.9)μg/L, (309.2±182.7) U/L in tuberculous effusions.There were signiifcant differences in CEA, CYFRA21 and LDH concentrations among malignant and tuberculous effusions (t=45.1, 27.4, 18.8 respectively, all P<0.01). Conclusion Ultrasound-guided pleural biopsy combined with CEA, CYFRA21 and LDH in pleural effusions had an important value in the etiological diagnosis of pleural effusions, while CA125 showed little value in the differential diagnosis.

Objective To evaluate the role of damage control surgery (DCS) in the diagnosis and treatment of sharp abdominal injury combined with multiple trauma.Methods Sixty patients with sharp abdominal injury accompanied by multiple trauma treated from January 2005 to August 2014 were reviewed retrospectively.There were 55 males and 5 females,aged at 15-79 years (mean,32.08 years).Thirty patients underwent definite operative treatment (control group),and 30 patients had DCS (DCS group).Between-group differences were examined in pre-and post-operative hemodynamic changes,function recovery,cure rate and complication incidence.Results All patients showed improved hemodynamic parameters after operation.The cure rate was 97％ (29/30) in DCS group versus 50％ (15/30) in control group (P ＜ 0.05).Complications were reported in 17％ (5) of the patients in DCS group versus 40％ (12) of the patients in control group (P ＜ 0.05).Conclusion DCS is associated with decreased rate of complications and increased cure rate in the treatment of sharp abdominal injury combined with multiple trauma.

Objective To investigate the experience of diagnosis and treatment of abdominal penetrating injury with large vessels damage.Methods The clinical data of 18 patients with abdominal large vessels injuries in our hospital from Jan 2003 to oct 2014 were analyzed retrospectively.Results 18 cases of large vessels injuries,accounting for 16.21％ during the same period of all penetrating wounds (18/111),emergency laparotomy was performed.There were 8 cases of arterial injury,4 cases of concurrent arteriovenous injury,6 cases of venous injury,Arterial and venous broken walls were repaired,splenic artery and venous ligation and splenectomy were performed.Vascular repair success rate was 100％,Intraoperative blood loss was 500-6 000 ml,average (3 750 ±670) ml.Operating time varied from 2.5 to 7 h,average (3.9 ±0.8) h.All patients were cured.12 cases were followed-up for 2-36 months,mean follow-up time was (15 ± 7) months,ultrasonography showed normal blood flow without complications.Conclusions Emergency surgical exploration and limited fluid resuscitation is the most effective therapy in abdominal penetrating injury involving large vessels.

Objective To investigate the changes of CD4 + CD25 + Foxp3 + regulatory T cell (Treg) and relative cell factors in peripheral blood of steroid-resistant allergic rhinitis (AR) patients,and to study their functions in occurrence of steroid-resistant AR.Methods The CD4 + CD25 + Foxp3 + Treg cell in 30 cases general physical examination (The control group),30 cases steroid-sensitive AR patients (steroidsensitive group) and 30 cases steroid-resistant AR patients (steroid-resistant group) were detected by flow cytometry.The levels of serum interleukin 10 (IL-10) and transforming growth factor β1 (TGF-β1) in the three groups were detected by enzyme-linked immunoadsorbent assay (ELISA).Results Compare to the control group,proportion of CD4 + CD25 + Foxp3 + Treg cell and the levels of serum IL-10,TGF-β1 in steroid-sensitive group and steroid-resistant group were significantly reduced (P ＜ 0.01).The proportion of CD4 + CD25 + Foxp3 + Treg cell and the levels of serum IL-10,TGF-β1 in steroid-resistant group were decreased significantly than steroid-sensitive group (P ＜ 0.01).The proportion of CD4 + CD25 + Foxp3 + Treg cell were positively correlated with the serum IL-10,and TGF-β1 (P ＜ 0.01).Conclusions The reduced proportion of CD4 + CD25 + Foxp3 + Treg cell and lower serum IL-10,TGF-β1 play an important role in the occurrence of steroid-resistant AR patients.

Hemangioma ; pathology ; Hemangiosarcoma ; pathology ; Humans

Objective: To explore the clinical effect of Shufeng Tongqiao and Yifei Jianpi prescription in the treatment of allergic rhinitis. Methods: From September 2015 to October 2017, 60 patients with allergic rhinitis in the Traditional Chinese Medicine Hospital of Tongxiang were selected according to include and exclude standards.The patients were randomly divided into two groups according to the digital table, with 30 cases in each group.The control group was treated with conventional western medicine: loratadine tablets combined with budesonide nasal spray.The treatment group was given traditional Chinese medicine on the basis of the control group.Before and after treatment, the nasal congestion, runny nose, nasal itching, sneezing four indicators were recorded in the two groups.And nasal discharge, tears flowed pharyngeal from eye pain, oral cavity on the forehead, nose, or pain, headache, five secondary indicators, as well as in the case of a change rhinitis, quality of life questionnaire were collected.The data were statistically analyzed. Results: Before treatment, there were no statistically significant differences in the main symptoms, secondary symptoms, serum IgE and quality of life between the two groups (all P>0.05). After 3 months of treatment, all the indicators in the two groups were significantly improved compared with those before treatment, and the differences were statistically significant (all P<0.05). In addition, the improvement of main symptoms and serum IgE in the treatment group were better than those in the control group, and the differences were statistically significant (z/t=-2.708, -2.033, -3.757, -2.208, -2.432; P=0.007, 0.042, 0.000, 0.027, 0.018), but there were no statistically significant differences between the two groups in terms of subtypes and quality of life improvement (P=0.488, 0.448, 0.519, 0.228, 0.278, 0.338). After 1 year of follow-up, the mean scores of each group were analyzed and compared.The indicators in the treatment group showed a different degree of recovery after 3 months of treatment.However, compared with before treatment, the indicators were still significantly improved.The scores of nasal obstruction, runny nose, nasal itching, sneezing, quality of life, and serum IgE in the treatment group were (1.13±0.81)points, (1.00±0.94)points, (0.93±0.74)points, (1.00±0.74)points, (6.13±2.30)points, (92.23±12.55)points, compared with those before treatment, the differences were statistically significant (t/z=-5.575, -5.222, -6.281, -5.918, 5.633, 9.199, all P<0.01). Compared with the control group, all indicators were significantly better, the differences were statistically significant (z/t=-2.388, -2.390, -2.738, -2.350, 4.800, 4.022, 4.444, 4.356, 5.934, -2.023, -4.381; P=0.017, 0.017, 0.006, 0.019, 0.028, 0.045, 0.035, 0.037, 0.015, 0.048, 0.000). After 3 months of clinical treatment and 1 year follow-up analysis, the total effective rate of the treatment group was 93.3%, that of the control group was 86.7%, the difference between the two groups was statistically significant (Z=-2.221, P=0.026). Conclusion The clinical efficacy of Shufeng Tongqiao and Yifei Jianpi prescription combined with western medicine in the treatment of allergic rhinitis is more significant than conventional western medicine alone, and the long-term efficacy is significant, which can effectively reduce the symptoms of patients, improve the quality of life of patients, and significantly reduce the level of serum IgE.