1.Chemical constituents in leaves of Acanthopanax gracilistylus
Shiying AN ; Shihui QIAN ; Jianqin JIANG ; Kangcai WANG
Chinese Traditional and Herbal Drugs 1994;0(10):-
Objective To study chemical constituents in the leaves of Acanthopanax gracilistylus.Methods The chemical components were isolated and purified by silica gel,ODS C-18,and Sephadex LH-20 column chromatogram.The chemical structures were elucidated on the basis of physicochemical properties and spectral data.Results Seventeen compounds were isolated and identified as(-)-kaur-16-en-19-oic acid(Ⅰ),quercetin(Ⅱ),kaempferol(Ⅲ),protocatechuic acid(Ⅳ),acankoreoside A(Ⅴ),acantrifoside A(Ⅵ),3?,11?-dihydroxy-20(29)-lupene-23,28-dioic acid(Ⅶ),?-sitosterol(Ⅷ),daucosterol(Ⅸ),palmitic acid(Ⅹ),rutin(Ⅺ),stigmast-5,22-dien-3-O-?-D-glucopyranoside(ⅩⅡ),acankoreagenin(ⅩⅢ),3,11-dihydroxy-23-oxo-20(29)-lupen-28-oic acid(ⅩⅣ),3-hydroxy-23-oxo-20(29)-lupen-28-oic acid(ⅩⅤ),myristin(ⅩⅥ),and acanthopanaxgric acid(ⅩⅦ).Conclusion Compounds Ⅱ-Ⅳ,Ⅶ,Ⅺ,ⅩⅡ,ⅩⅣ,and ⅩⅤ are obtained from the leaves of the plant for the first time and compounds ⅩⅦ is a new proved compound named acanthopanaxgric acid.
2.A new ursane caffeoyl ester from the seeds of Impatiens balsamina L.
Jing LEI ; Shihui QIAN ; Jianqin JIANG
Journal of China Pharmaceutical University 2010;41(2):118-119
A new triterpene ester,α-amyrin caffeate(1),was isolated from the seeds of Impatiens balsamina L.
3.Application of nanotechnology in the diagnosis and therapy of melanoma
Jianqin TANG ; Xiaoyang HOU ; Guan JIANG ; Zhiping WEI ; Yanqun LIU
Journal of International Oncology 2016;43(11):871-873
The current treatments of metastatic malignant melanoma include chemotherapy,targeted therapy,immune therapy and radiation therapy,but the treatment outcome is far from optimism.In order to im-prove the treatment efficiency,it is urgent to improve early diagnosis,and develop more effective treatment drugs and delivery systems.The application of nanotechnology in the diagnosis and therapy of melanoma can re-duce the resistance to the drugs,increase efficacy and reduce side effects.
4.Progresses of intravoxel incoherent motion DWI in evaluation of treatment response of tumors
Jianqin JIANG ; Lei CUI ; Xiaowen GU ; Rongfang CAI
Chinese Journal of Medical Imaging Technology 2017;33(6):949-953
Intravoxel incoherent motion (IVIM) can distinguish the molecular diffusion from the pseudo-diffusion of microcircular perfusion to obtain true diffusion coefficient (D),pseudo-diffusion coefficient (D*) and perfusion fraction (f),which are sensitive to detect alterations in cellularity and microcirculation perfusion.IVIM can also evaluate early therapeutic effects,optimize treatment plan,predict prognoses,and provide information for choosing appropriate treatment methods.In this paper,the principle of IVIM and its application in tumor response evaluation were reviewed.
5.Comparison and analysis of two potency assay methods of protamine sulfate
Ping LIU ; Jianqin GU ; Jie SUN ; Yue HU ; Zhuhui JIANG ; Zhaocheng ZHENG ; Liming TANG
Chinese Journal of Biochemical Pharmaceutics 2016;36(8):145-148
Objective To analyze and compare two potency assay methods of protamine sulfate.Methods Heparin titration method was according to foreign pharmacopoeia,while biological assay method was according to China pharmacopoeia(2015).Results The absorbance at the end-point was stable at 0.10 mg/mL and 0.15 mg/mL test solutions.The relative standard deviations(RSDs)of potency results were all less than 5%.Three test solutions and volumes of the titrant had a good linear relationship(R2 =1.000).The results of titration method were significantly related to those of biological assay(P=0.013),with similar RSD(P>0.05).However,the potency of titration method were significantly lower than those of biological assay (P=0.045).Conclusion Heparin titration method is good-using,convenient,and need to be applied widely at home.
6.Effect of self-management education on medication compliance and self-efficacy of patients with schizophrenia in rehabilitation period
Jufang JIANG ; Jianqin PEI ; Zijuan ZHANG ; Mingru HOU ; Huizhen YAO ; Yan CAI
Chinese Journal of Practical Nursing 2017;33(15):1155-1159
Objective To observe the effect of medication compliance and self-efficacy of schizophrenia patients with diabetes by continuing self-management education. Methods A total of 60 patients with schizophrenia with diabetes diagnostic criteria were divided into experimental group (30 cases) and control group (30 cases) by the admission number, 2 groups received conventional drug treatment, the control group received general preaching health education pattern, were each issued a health education manual, with schizophrenia and diabetes health knowledge division, the test group on the basis of the continuation of the implementation of self-management education, followed up 12 months after discharge, compared 2 groups of patients with medication compliance and recurrence rate, with General Perceived Self-Efficacy Scale (GSES) assessment level of 2 groups of patients with self-efficacy, fasting blood glucose (FPG) was determined by automatic biochemical analyzer, 2 hours postprandial blood glucose (2 hPBG). Results Six months after discharge, 82.1%(23/28) cases were complete compliance, 14.3%(4/28) cases of partial compliance, 3.6%(1/28) cases of non-compliance, 55.2%(16/29)cases of the control group complete compliance, 27.6%(8/29) cases of partial compliance, 17.2%(5/29) cases of non-compliance, the differences between two groups were statistically significant (χ2=37.41, P<0.05). The 12 month test group of full compliance discharged 75.0%(21/28) cases, 14.3%(4/28) cases of partial compliance, 10.7%(3/28) cases of non-compliance, 31.0%(9/29) cases of the control group complete compliance, 31.0%(9/29) cases of partial compliance, 37.9%(11/29) cases of non-compliance, the test group compliance was higher than the control group (χ2=11.27, P<0.05). The score after 6 months and 12 months respectively for the test group general self-efficacy scored 35.32 ± 2.02, 34.18 ± 1.77, control group scored 24.03 ± 3.04, 22.48 ± 2.01, the differences between two groups were statistically significant (t=16.445, 23.304, P<0.01). After 6 months in test group FPG and 2 hPBG were (5.71 ± 1.05), (9.46 ± 1.37) mmol/L, control group were (7.79 ± 1.05),(12.28 ± 2.07) mmol/L, the differences between two groups were statistically significant (t=7.483, 6.023, P<0.01). 12 months after discharge in test group FPG and 2 hPBG respectively (5.89±1.13), (9.68±1.09) mmol/L, control group (9.14±1.19), (13.17±1.42) mmol/L, test group FPG and 2 hPBG were lower than the control group (t=10.550, 7.431, P<0.01). After 6 months and 12 months, the recurrence rate of experimental group were 7.1% (2/28) and 24.1% (7/29) respectively, and control group were 14.3%(4/28) and 44.8%(13/29), the recurrence rate of experimental group was lower than the control group, there was significant difference between 2 groups (χ2=4.326, 6.225, P< 0.05 or 0.01). Conclusions Self-management education can improve the medication compliance and self-efficacy, improve mental symptoms and sugar metabolism, and reduce the recurrence rate.
7.Serum Level of Testosterone and Estradiol,and Clinical Features in Female Patients with Climacteric Acne
Jianqin WANG ; Shaomeng LONG ; Renshan ZENG ; Shaosheng TANG ; Jie YANG ; Jiang WU
Chinese Journal of Dermatology 1994;0(06):-
0.05),but the ratio of testosterone/estradiol was significantly higher in patients than that of the controls(P
8.Correlation of serum uric acid and early renal damage in patients with type 2 diabetes mellitus
Hua XIE ; Min CHEN ; Yanqiu CHEN ; Yifan LIN ; Danfeng XU ; Jingjing JIANG ; Weijia SUN ; Min ZONG ; Jianqin SUN
Chinese Journal of Endocrinology and Metabolism 2011;27(3):237-239
The association of serum uric acid ( SUA ) and urine albumin-to-creatinine ratio ( ACR ) in patients with type 2 diabetes mellitus was explored. The ACR abnormal rate was higher in hyperuricemia group( P<0.01 ). ACR level was positively correlated with SUA( P<0.01 ). The general linear model showed that SUA was a risk factor in ACR. Patients with hyperuricemia and type 2 diabetes mellitus were apt to have abnormal ACR and develop early renal damage.
9.Chemical constituents from Hedyotis diffusa.
Weihua HUANG ; Youbin LI ; Jianqin JIANG
China Journal of Chinese Materia Medica 2009;34(6):712-714
OBJECTIVETo investigate the chemical constituents from Hedyotis diffusa.
METHODThe compounds were isolated and purified by various chromatographic techniques and identified by their physicochemical properties and spectral data.
RESULTEight compounds had been reported in last paper, and this time eight more compounds were isolated and identified as 6-hydroxystigmasta-4,22-dien-3-one (1), 3-hydroxystigmasta-4,22-dien-7-one (2), 2-hydroxy-3-methylanthraquinone (3), 2,6-dihydroxy-3-methyl-4-methoxyanthraquinone (4), iso-scutellarein (5), isoetin (6), aesculetin (7), gypsogenic acid (8).
CONCLUSIONCompounds 1-3, 5-8 were obtained from the genus Hedyotis for the first time.
Hedyotis ; chemistry ; Organic Chemicals ; analysis ; isolation & purification
10.Effects of low-glycemic index meal replacement on management of patients with type 2 diabetes mellitus
Min CHEN ; Yanqiu CHEN ; Li HUA ; Min ZONG ; Fei XIAO ; Qing YI ; Hua XIE ; Wei SUN ; Aifang CHEN ; Qianru TANG ; Jingjing JIANG ; Yifan LIN ; Danfeng XU ; Jianqin SUN
Chinese Journal of Endocrinology and Metabolism 2012;28(1):45-47
A total of 127 type 2 diabetic patients were divided into low glycemic index meal replacements (intervention) group and standard food-based diet (reference) group in an experiment for 12 weeks.The results showed that fasting plasma glucose,postprandial 2 h plasma glucose,fasting insulin,and homeostasis model assessment insulin resistance(HOMA-IR) in the intervention group decreased significantly after 12 weeks trial ( P<0.05 or P<0.01 ).However,there were no significant changes in lipid profile and HbA1C in intervention group.In addition,percentage of body fatty,visceral fatty area,and waist-hip ratio also decreased in intervention group( all P<0.01 ).Superoxide dismutase and glutathione levels increased significantly in intervention group by the end of trial (both P<0.01 ),while malondialdehyde was decreased (P<0.01 ).There were no significant changes in the aforementioned indices in the reference group.Weight,body mass index,and waist circumferences were decreased in both groups,but without significant difference between the two groups.