1.Changes of spasmolysant airways in different phrases in asthmatic patients after bronchodilation test
Jianqin WEI ; Zehua DONG ; Jin HUANG
Journal of Jilin University(Medicine Edition) 2006;0(03):-
Objective To explore the linearic regularity of airways′ spasm and spasmolysis in asthmatic patients,and provide theory bases for clinic treatment.Methods After regular bronchodilation test,the pulmonary function in(16 asthmatic) patients and 14 volunteers were examined 15 min,30 min, 1 h,2 h and 4 h later,respectively.The indexes included forced vital capacity(FVC),forced expiratory flow in one second(FEV_1),peak expiratory flow(PEF),maximal midexpiratory flow(MMEF),expiration of 50% FVC(V_(50)) and expiration of 75% FVC(V_(25)).Results 2 h after bronchodilation test,the big airways dilated completely(P
2.Standardized management of patients with coronary heart disease in Yuetan Community of Beijing
Wenli ZHOU ; Jianqin DONG ; Xiumei TONG
Chinese Journal of General Practitioners 2009;8(9):656-657
nses (P<0.01).Standardized management is favorable in community management of patients with coronary heart disease.
3.Study on blood supply of lung metastasis with trans-pulmonary arterial lipiodol infusion
Jianqin ZHOU ; Weihua DONG ; Qiang OUYANG ; Heng CHANG ; Xiangsheng XIAO
Journal of Interventional Radiology 2006;0(08):-
Objectvive To evaluate the blood supply of pulmonary metastases using small volume of lipiodol through pulmonary arterial infusion. Methods 10 cases of lung metastasis were enroled including the primary tumors of liver cancer(n = 5), renal carcinoma(n = 3), chordoma(n = 1) and malignant neurofibroma (n = 1). Plain CT scan was performed to exclude calcification or ossification within metastasis and then pulmonary arterial DSA was undertaken to evaluate tumor vessels or staining. After pulmonary arteriovenous fistula or other anomalous circulation was excluded by lobar arterial DSA, small volume of lipiodol was infused under fluoroscopy (0.5 -1.5 ml for each lobar artery, total volume less than 3.0 ml). CT scan was immediately performed. Blood supply of the pulmonary metastases was assessed according to the accumulation of lipiodol on CT scans. Results No cases but one experienced cough, expectoration, suffocating or dyspnea. No complication of cerebral or visceral embolism occurred. Totally 27 nodules were studied including 6 nodules with cloudy lipiodol accumulation and 6 nodules with tiny granules of lipiodol accumulation. No enlarged tumor vessel or tumor stain was observed within all 27 nodules on pulmonary arterial DSA. Conclusions Pulmonary artery supplys only parts of pulmonary metastases, especially those sited at the peripheral region of the lung. Infusion of small volume of lipiodol through pulmonary artery is safe, and the increased density of lung field could return normal after several days.
4.Effects of shenbao recipe on expressions of CTGF and MMP-9 in diabetic nephropathy rats.
Wei LIU ; Jianqin WANG ; Xiaodong WANG ; Qinghua YANG ; Dong WANG
China Journal of Chinese Materia Medica 2010;35(14):1874-1877
OBJECTIVETo investigate the effects of Shenbao recipe on expressions of CTGF and MMP-9 in the kidney of diabetic rats.
METHODWistar rats were randomized divided into control group (group C), diabetic rat group (group D) and Bao'shen recipe treatment group (group DB). Streptozotocin(STZ) was injected through abdominal cavity to make models of diabetic rats. Administration for 8 weeks, renal function and pathological changes of rats' renal tissue were observed, protein expression of CTGF and MMP-9 in renal tissue was investigated by immunohistochemistry analysis.
RESULTCompared with group C, expressions of CTGF in renal tissue of group D were higher [(0.234 +/- 0.009) vs (0.146 +/- 0.007) , P < 0.01], while the expressions of MMP-9 were lower [(0.146 +/- 0.006) vs (0.236 +/- 0.007), P < 0.01]. Kidney hypertrophy index, 24-hour urinary protein, blood glucose, cholesterol and serum creatinine were increased significantly in the group D. The level of MMP-9 expression was increased [(0.175 +/- 0.007) vs (0.146 +/- 0.006), P < 0.01], while the level of CTGF expression was reduced [(0.194 +/- 0.008) vs (0.234 +/- 0.009), P < 0.01] by using Shenbao recipe. In group DB, all index including kidney hypertrophy index, 24-hour urinary protein, cholesterol and serum creatinine were obviously lower than diabetic rat group.
CONCLUSIONShenbao recipe can depress the expressions of CTGF and increase the expressions of MMP-9 in the kidney of diabetic rats, which can be served as a protective effect to prevent progress of diabetic nephropathy.
Animals ; Connective Tissue Growth Factor ; genetics ; metabolism ; Diabetic Nephropathies ; drug therapy ; genetics ; metabolism ; Disease Models, Animal ; Drugs, Chinese Herbal ; administration & dosage ; Gene Expression ; drug effects ; Humans ; Kidney ; drug effects ; enzymology ; metabolism ; Male ; Matrix Metalloproteinase 9 ; genetics ; metabolism ; Rats ; Rats, Wistar
5.Performance evaluation of community continuous rehabilitation intervention on patients with stroke
Yongli WANG ; Xueping DU ; Jianqin DONG ; Lan DING ; Jianlan WANG ; Qingying HENG ; Yingyu JIA ; Xiaoying LIU ; Yuling LIU ; Yuanyuan YANG
Chinese Journal of Practical Nursing 2008;24(30):1-4
Objective To explore the pathway of continuous rehabilitation intervention in community stroke patients and to evaluate its effect. Methods Stroke patients (64 cases) were selected from Yuetan community as the rehabilitation group by objective sampling based on inclusive and exclusive standard and 64 stroke patients wre selected from other community in Xicheng district as the control group. At the same time, 16 doctors and nurses from 10 clinics of Yuetan community health service center were trained and they gave reha-bilitative intervention to the rehabilitation group. After intervention for 6 months, the effect of rehabilitative in-tervention was evaluated compared with the control group who did not receive rehabilitative intervention. Re-suits The Fugl-Meyer score of the rehabilitation group was (76.14±12.48), the score of the control group was (19.36±14.32),which had significant difference compared with the rehabilitation group, P < 0.05. The Batthel index of the rehabilitation group was (72.25±10.22), the index of the control group was (22.62±9.71),which was significantly different from that of the rehabilitation group, P < 0.05.Besidcs, the rate of knowing health knowledge and healthy exercise in the rehabilitation group was higher than that of the control group, P < 0.05. Condusions The rehabilitation information net and systemic community rehabilitation intervention can im-prove the motor ability and the ability of daily activity for patients with stroke.
6.Development of a diagnosis model for active pulmonary tuberculosis using mass spectrometry and pro-tein chip
Xueqiong WU ; Junxian ZHANG ; Yan LIANG ; Mei DONG ; Bin YI ; Ruijuan MA ; Hua WEI ; Jianqin LIANG ; Yourong YANG ; Hongbing CHEN ; Cuiying ZHANG ; Jufang HE ; Hong WU ; Zhongxing LI ; Youning LIU
Chinese Journal of Microbiology and Immunology 2008;28(11):1040-1043
Objective To develop a diagnosis model for active pulmonary tuberculosis. Methods The proteomic fingerprinting of 264 sera from active tuberculosis patients and controls were analyzed using the surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF-MS) and protein-chip technology. The peaks were detected and filtrated by Ciphergen PrnteinChip(R) Software (version 3.1.1). Using the Biomarker Pattern 5.0 software, a diagnostic model was developed for diagnosis of active tuberculosis. Re-sults Fifty protein peaks were significantly different between the patients with active pulmonary tuberculosis and the controls with overlapping clinical features (P<0.01). Five protein peaks at 4360, 3311, 8160, 5723, 15173 m/z were chosen for the system classifier and the development of diagnosis model 1. The model differenti-ated the patients with active pulmonary tuberculosis from the controls with a sensitivity of 83.0%, and a speci-ficity of 89.6%. The diagnostic accuracy was up to 86.4%. Three protein peaks at 5643, 4486, 4360 m/z were chosen for the system classifier and the development of diagnosis model 2. The model differentiated the pa-tients with active pulmonary tuberculosis from the controls with a sensitivity of 96.9%, and a specificity of 97.8%. The diagnostic accuracy was up to 97.3%. Conclusion It might be a new diagnostic test for the de-tection of sera from the patients with active pulmonary tuberculosis using SELDI-TOF-MS and protein chip.
7.Survey on satisfaction with community health service among residents in Beijing Yuetan subdistrict
Ning LI ; Xueping DU ; Jianqin DONG
Chinese Journal of General Practitioners 2018;17(9):683-687
Objective To survey on the satisfaction with community health service among residents in Beijing Yutan subdistrict and its influencing factors.Methods From February 2017 to April 2017,a questionnaire survey was carried out among 829 residents over 15 years old in Beijing Yuetan community.The overall satisfaction with the community health service was surveyed,and its correlations with sex,age,educational level,occupation,medical insurance type,family per capita income,and chronic diseases of residents were analyzed.Results The satisfaction rates with various items of community health services were all above 75%,except that of drug types and facilities.The satisfaction with nursing service,service attitude,communication,equipment,convenience,waiting time and institutional environment was correlated with the age of the residents (x2 =14.913、16.144、13.966、14.279、15.208、23.590、13.746,P < 0.05),but not correlated with the educational level of residents (P > 0.05).There were significant differences in satisfaction with nursing service,convenience,waiting time and institutional environment among residents with different occupations (x2 =7.379,14.837,9.471,14.837,P < 0.05);there was significant difference in satisfaction with drug types among the residents with different payment methods (x2 =11.405,P < 0.05),and there was significant difference in the satisfaction with image accuracyandthe facilities among residents with different family income (x2 =9.808,10.117,P < 0.05).The satisfaction degree with medical care,nursing service,communication,image accuracy,equipment,andwaiting time was significantly different among residents with different chronic diseases (x2 =4.387,5.285,9.908,11.622,3.903,6.285,P < 0.05).Conclusion The overall satisfaction with the community health service among Yuetan residents is high;however,more attention should be paid to the health management for women and elderly patients and patients with chronic disease and low income.
8.An 11-site cross-section survey on the prevalence of nutritional risk, malnutrition (undernutrition) and nutrition support among the diagnosis-related group of elderly inpatients younger than 90 years old with coronary heart disease in North and Central China
Jingyong XU ; Yan WANG ; Puxian TANG ; Mingwei ZHU ; Junmin WEI ; Wei CHEN ; Huahong WANG ; Yongdong WU ; Xinying WANG ; Li ZHANG ; Suming ZHOU ; Jianqin SUN ; Birong DONG ; Yanjin CHEN ; Huaihong CHEN ; Huiling LOU
Chinese Journal of Clinical Nutrition 2018;26(3):149-155
Objective To investigate the prevalence of nutritional risk,undernutrition and nutritional support among elderly inpatients with coronary heart disease in 11 tertiary A hospitals in China.Methods Records of elderly patients under the age of 90 with coronary heart disease were collected between March 2012 and May 2012 from 11 tertiary A hospitals in China following the direction of diagnosis related group of Beijing government.Results A total of 1 279 consecutive cases were recruited with the average age 74 years old (65-89).The total nutritional risk prevalence was 28.14% (360/1 279).The prevalence of nutritional risk and nutritional risk score ≥ 5 increased with age.The prevalence of nutritional risk (12.88% vs.30.08% vs.42.28%) and nutritional risk scored ≥5 (10.86% vs.18.61% vs.27.78%)increased with age.Judging from BMI,most patients were overweight or obese (BMI ≥ 24 kg/m2),accounting for 53.0% of the total,and prevalence of nutritional risk in this subgroup was 15.12% (96/635).The prevalence of nutritional risk in patients with normal BMI was 34.24%.The prevalence of undernutrition defined as BMI< 18.5 kg/m2 was 4.25% (51/1 279),among which patients with score ≥ 5 account for 64.7% (33/51).The prevalence of undernutrition defined as nutritional impairment score =3 was 7.58% (97/1 279).In patients with nutritional risk,57 were administrated nutrition support (16.6%);in patients without nutritional risk,21 received nutrition support,mostly parenteral nutrition (16 cases,76.2%).In patients with nutritional risk [(79.46± 7.19) years vs.(76.40± 6.16) years],there were statistically significant difference between those who received nutrition support and those who did not in terms of age and the ratio of patients with nutritional risk scored≥5 (35.1% vs.17.1%) (P =0.001,P=0.002).Conclusions The prevalence of nutritional risk in patients with coronary heart disease was high.The prevalence of undernutrition was low.Prevalence of overweight and obese was high,but there was still nutritional risk in this group of patients.The patients who received nutrition support were older and had high nutritional impairment score,but the indication is not rationale.