Objective:To evaluate the effectiveness and treatment feature of maxillary incisor extraction in orthodontics.Methods:9 patients underwent orthodontic treatment with maxillary incisor extraction,5 female and 4 male,with an average age of 1 7.2 years at the start,were included.5 patients were treated by extraction of both upper incisors and lower first premolars,4 by extraction of the abnor-mal incisor and the first premolars in the other three quadrants.Cephalometric and Bolton index analysis were carried out.Results:Sat-isfactory treatment results were observed in all patients.Before treatment the predicted Bolton index of the patients of the anterior ratio and the overall ratio were 80.1 4% and 91 .3%,after orthodontic treatment 78.68% and 90.28%,respectively.Cephalometric analysis showed that U1 -NA(mm),U1 -NA,L1 -NB(mm),L1 -NB,U1 -SN,L1 -MP,UL-E and LL-E were decreased(P <0.05).Conclu-sion:Individual treatment plan based on Bolton index analysis and the corresponding techniques and methods,the patients with abnor-mal upper incisors can be effectively treated with the extraction of maxillary incisors.

Objective To compare the efficacies of automatic erythrocyte sedimentation rate (ESR) analyzer using EDTA as blood anticoagulant ,traditional Westergren method and ESR analyzer using sodium citrate as blood anticoagulant in detecting ESR , in order to chose the appropriate one for clinical application .Methods A total of 40 samples were collected and divided into 3 groups .The ESR was detected by using XC‐A30 automatic ESR analyzer using EDTA as blood anticoagulant (XC ESR analyzer) , Westergren method and VISION‐C automatic ESR analyzer using sodium citrate as blood anticoagulant (VISION ESR analyzer) ,re‐spectively .Statistical analysis was used to comparing the detection results of ESR among the three methods .The repeatability test was carried out for evaluating repeatability of VISION ESR analyser .Results There was statistically significant difference in ESR detected by using Westergren ,XC ESR analyzer and VISION ESR analyzer(F=86 .497 ,P=0 .000) .There was statistically signifi‐cant difference in ESR between that detected by using XC ESR analyzer and that detected by using Westergren (t= -4 .08 ,P=0 .004) .The ESR detected by using VISION ESR analyzer was positively correlated with that detected by using Westergren (r=0 .975 ,P=0 .000) .There was no statistically significant difference in ESR between that detected by using VISION ESR analyzer and that detected by using Westergren(t=0 .65 ,P=0 .638) .The repetitive tests of analyzer shown that the within‐run coefficient of variation(CV) and between‐run CV both were less than 10% .Conclusion The ESR detected by using VISION ESR analyzer which is simple operation and with credible result has good correlation with that detected by using Westergren .The VISION ESR analyzer might be suitable for clinical application .

Ultrasmall superparamagnetic iron oxide (USPIO),as the contrast agent of MRI,possesses two major properties:long half time in the plasma and specific binding with macrophages.Compared with gadolinium,widely-used in clinic presently,USPIO has its unique advantages in diagnosis of central nervous system diseases,though which still need further clinical verification.This article reviews the application of USPIO in MRI diagnosis of some central nervous system diseases.

OBJECTIVE:To study the compatible stability of Levofloxacin hydrochloride injection with Inosine in sodium chloride injection. METHODS:Levofloxacin hydrochloride injection was mixed with Inosine in sodium chloride. Then UV spectrophotometry was applied to detect the change of content at 20 ℃ within 6 hours. The change of appearance,pH value,content of mixture,insoluble particle were also observed. RESULTS:The change of appearance,pH value,content of mixture,insoluble particle in mixture was not found out. CONCLUSION:Levofloxacin hydrochloride injection mixing with Inosine in sodium chloride injection is suitable for clinical use within 6 h.

Objective To study the effect of monosialoteterahexosyl ganglioside (GM1) on neurobehavioral development in premature infants with white matter damage. Methods A total of 636premature infants who were hospitalized in NICU of two hospitals from Jan 2005 to May 2009 received routine bedside cranial sonography detection before 1 week-aged. Forty premature infants were diagnosed as being premature white matter damage and divided into the treatment group (20 cases ) and the control group (20 cases) randomly. The cases in the treatment group accepted GM1 20 mg additional to 5% glucose solutionthe iv drip, one time per day,for a cycle of 14 d. 1 -3 cycles were given in accordance with patient's condition. Other treatments were same to the control group. All cases were evaluated by neonatal behavioral and neurological assessment (NBNA) at the rectified age of 40 gestational weeks and by Children's Developmental Center of China (CDCC) test at 3 months-aged and 12 months-aged. Results The NBNA scores of the treatment group (38.10±0.91) were significantly higher than the control group (36.10±1.59) at the rectified age of 40 gestational weeks (P＜0.01). The indexes of mental development(MDI) and psychomotor performance development (PDI) by the CDCC tests in the treating group (3 months-aged MDI:91.66±6.38;PDI:87.11±5.57; 12 months-aged MDI:104.10±6.45; PDI:100.46±3.87) were significantly higher than those in the control group (3 months-aged MDI:81.07±0.72; PDI:81.90±6.70; 12 months-aged MDI:98.45±8.57; PDI:95.91±6.59) at 3 months-aged and 12 months-aged ( P ＜ 0. 05 ). Conclusion GM1 can accelerate the neurobehavioral development in premature infants with white matter damage.

Objective To study the chemical constituents of Bidens bipinnata and search for bioactive natural products, which have the anticancer and antiinflammation activities. Methods The six compounds were isolated by a combination of silica gel, reversed phase silica gel column chromatography, and polyamide column chromatography. Their structures were identified by spectral methods. Results Ten compounds were isolated and six structures were identified. They are trideca-2-?-D-glucopyranosyl-1, 13-dihydroxy-3 (E), 11 (E)-en-5, 7, 9-triyne (Ⅰ), trideca -2-?-D-glucopyranosyl-1, 13-dihydroxy-11 (E)-dien-3, 5, 7, 9-tetrayne (Ⅱ), hyperoside (Ⅲ), 6-O-(3″, 6″-diacetyl-?-D-glucopyranosyl)-6, 7, 3′, 4′-(tetrahydroxyaurone) (Ⅳ), 6-O-(6″-acetyl-?-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (Ⅴ), 6-O-(4″, 6″-diacetyl-?-D-glucopyranosyl)-6, 7, 3′, 4′-tetrahydroxyaurone (Ⅵ). Conclusion Compound Ⅱ is a novel compound, compound Ⅴ is isolated from this plant for the first time.

Objective: To investigate the Ventral Pallidrm′s function of cardiovascular adjustment by observing the changes of the rats′blood pressure. Methods:Ten SD rats′blood pressure were respectively observed through a catheter in one of the common carotid arteries after unilateral Ventral Pallidum stimulation by certain concertration,certain volume glutamate solution under stereotaxic guidance. Results:Glutamate stimulation on Ventral Pallidum caused elevation of the rats′blood pressure,thechanges were significant. Conclusion:Ventral Pallidum has a role in regulating blood pressure. It belongs to behavior related pattern and sympathetic regulated.

Objective To study the effect of danshao shugan granule combined with metformin in treatment of nonalcoholic fatty liver and its effects on lipid and uric acid metabolism.Methods 80 patients of nonalcoholic fatty liver who received therapy from February 2014 to February 2015 in our hospital were selected as research objects.According to random number table,those patients were divided into the observation group (n=40) cases in each group and the control group (n=40).The control group was treated with metformin, while the observation group was treated with danshao shugan granule combined with metformin.Then blood lipid level, FBG, FINS, IR, SUA level, SOD, MDA level, therapeutic effect of two groups after treatment were compared.Results After treatment, TG,TC in observation group was significantly less than the control group (P<0.05); FBG, FINS, IR, SUA levels in the observation group were significantly lower than the control group ( P<0.05 ); SOD level higher than the control group, MDA level significantly less than the control group (P<0.05); The total effective rate of observation group was statistically higher than that in the control group (P<0.05).Conclusion Danshao shugan granule combined with metformin is well for nonalcoholic fatty liver,which can improve the glucose, lipid, uric acid metabolism and insulin resistance, and can protect the liver function.

5 mm had surgery in 100%. Conclusion Most severe CHD could be detected prenatally by fetal echocardiography, and the pregnancy should be terminated. The critical NCHD should be diagnosed by echocardiography for corrective or palliative surgery as early as possible in the first days of life. In mild cases of left to right shunts may close spontaneously, they should be followed up regularly.

Objective To explore the value of craniocerebral CT angiography(CTA) to evaluate the prognosis in patients with acute cerebral infarction(ACI).Methods Craniocerebral CTA were performed in 70 patients with ACI at ≤6 h after onset.National Institutes of Health Stroke Scale(NIHSS) score and modeled Rank Scale(mRS) score were investigated at admission,discharge.Results There were 38 patients with visible occlusion on CTA and 32 patients with normal CTA.The patients with vessel occlusion on CTA had significantly worse discharge scores of NIHSS(P0.05).But for patients with vessel occlusion,the ratio of good prognosis in patients received thrombolytic treatment was higher than that of excluded thrombolysis(58.8% vs 31.8%;P