AIM: To observe the effects of Shexiang Baoxin Pill supplement on the patients with unstable angina pectoris(UAP),and study its mechanism. METHODS: Subjects recruited from 56 patients with UAP were randomly divided into control group and Shexiang Baoxin Pill group.The former received such therapy as expanding coronary artery,anticoagulation,adjusting lipemia 2 pills of Shexiang Baoxin Pill were given to each cases of the latter for 3 times every day orally besides routine therapy,3 months later,to review their plasm von Willebrand Factor(vWF) and fibrnogen 1(Fbg) and brachial artery endotheliumdependent dilation,its results were compared with the control group. RESULTS: Plasm vWF and Fbg of the control-group and Shexiang Baoxin Pill group decreased significantly((192.56%)?(27.37%) vs(179.23%)?(24.98%) P