Objective To investigate the clinical application value of procalcitonin(PCT)and C reactive protein(CRP)detection in the newborns with septicemia.Methods 50 newborns with septicemia in the hospital were enrolled as the observation group,and 50 healthy newborns at the same period were enrolled as the control group.Then the serum PCT and CRP levels and positive rates of two groups were detected and compared.The specificity,sensitivity,negative predictive values and positive predictive values of two indexes′single and combined application were analyzed,too.Results The serum PCT and CRP levels and positive rates of ob-servation group were all higher than those of control group,and the specificity and positive predictive values of two indexes′com-bined application were all higher than those of PCT and CRP single application(P <0.05).Conclusion The clinical application val-ues of PCT and CRP detection in the newborns with septicemia are high.The combined application is helpful for the early diagno-sis,it also can be as the curative effect of disease treatment effect.

BACKGROUND: Personality obstacle is a special type of psychopathy. Since it can reflect personal psychological traits, such as emotion, cognition, behavior mode and the ways one gets along with others, it may lead to meaningful functional impairments and psychological pains if they obviously deviate the normal range, resulting in functional malajustment to society, occupation, social ethics, rules and law. Therefore it deserves further investigation with respect to its criminological significance.OBJECTIVE: To investigate the influence of personality traits, age, educational degree, and marriage state before serving the sentence on criminal behavior of female offenders.DESIGN: A retrospective and control study based on patients.SETTING: Center of psychological sanitary in a hospital of a university.PARTICIPANTS: This study was carried out in the Psychological Sanitary Center of the First Affiliated Hospital of Chongqing Medical College between April 2004 and May 2004. Totally 223 female offenders who incarcerated in Chongqing Female prison were selected. Inclusion criteria: All participants aged from 18 to 60 years old and received above elementary school education. Exclusion criteria: Those who have definite body ailments or psychopaths. Finally totally 204 valid questionnaires were collected from female offenders who were then divided into violent criminal group( n = 120) and non-violent criminal group ( n = 84).METHODS: Totally 223 female offenders who incarcerated in Chongqing Female Prison were asked to fill personality diagnostic questionnaires (PDQ-R), Esonk' personality questionnaires(EPQ), and symptom self-rating chart(SCL-90). Finally totally 204 effective questionnaires were collected for statistical analysis with SAS software.MAIN OUTCOME MEASURES: Comparison of scores for three questionnaires between the two groups; relationship between general condition(age,educational degree and marriage state before incarceration) with the scores for the three questionnaires.RESULTS: The total score for PDQ-R was above 30 in both the two groups and without significant difference between them, ( P ＞ 0.05); the different results for EPQ between the two group was of statistical significance( P ＞ 0. 05); but the total scores for SCL-90 were markedly different between the two groups,( P ＜ 0.01 ); only "educational degree" was found positively correlated with "histrionic trait"; all items except "psychopathy" were close lined with the general state in EPQ questionnaires( P ＜ 0.05); "impulsion and the number of positive items" in SCL-90 were found related with the general condition( P＜ 0.05).CONCLUSION:All criminals have personality obstacle of different type and different degree, but the difference of personality traits between violent female offenders and non-violent female offenders was of no statistical significance.

Objective To perform radical abdominal trachelectomy on cases with cervical tumors for the removement of tumors and retain of fertility. Methods 4 cases with cervical tumors were performed radical abdominal trachelectomy in order to reserve the uterine function. Results Menstruation of all the 4 cases recovered after operation .Postoperative follow-ups revealed good results. Conclusion Radical abdominal trachelectomy can reserve the uterine function of patients with cervical tumors.However,further clinical observation needs to be performed to compare its survival rate with that of traditional modi operandi.

A protein was isolated by DEAE-cellulose Chromatography and ultracentrifuge from the fruits of Momordica charantid L., and identified by chemical and polyacrylamide gel electrophoresis methods. The molecular weight was 34 000; isoelectric point pH 8.4,N-end amino acid was leucine.It was composed of 17 kinds of amino acids. The protein has been shown to have antifertility action in male rats.

Objective To explore the clinical efficacy in the treatment of early diabetic nephropathy from ro-suvastatin combined with benazepril .Methods 107 patients of early diabetic nephropathy in our hospital were retro-spectively analyzed .On the basis of the conventional treatment of diabetes ,the control group were treated with benaze-pril;while the observation group were treated with rosuvastatin combined with benazepril .Before and after treatment , the improvement of the related indicators were observed , such as blood glucose ,lipids and renal function .The clinical efficacy were comprehensively evaluated .Results The level of the fasting blood glucose and 2-hour postprandial blood glucose of the observation group were lower than those of the control group , the difference was significant ( t=9.785,9.525,all P<0.05);the blood lipid levels such as TC ,TG and LDL-C in the observation group were signifi-cantly lower than those of the control group .But the levels of HDL-c was significantly increased , the difference was significant(t=9.938,10.283,10.475,9.782,allP<0.05);the indicators of renal function such as UAER ,Scr and BUN were significantly lower than those of the control group , the difference was significant ( t =9.938,12.341, 11.265,9.982,all P<0.05);The total effective rate of the observation group was 94.55%,significantly higher than the 76.92%of the control group, the difference was statistically significant (χ2 =10.120,P<0.05).Conclusion The effect of rosuvastatin combined with benazepril for the treatment of early diabetic nephropathy is very significant which is worthy applying in clinical practice .

BACKGROUND:Studies have shown that inflammatory cytokines may influence the prognosis after myocardial infarction, and play an important role in the process of cardiac remodeling. The non-hematopoietic effects of
erythropoietin have been confirmed:erythropoietin can reduce the inflammatory reaction through bending with
the erythropoietin on the surface of target cel membrane, thus decreasing the reperfusion injury after myocardial ischemia.
OBJECTIVE:To observe the effect of recombinant human erythropoietin on the inflammatory factor expression during cardiac remodeling in rats with acute myocardial infarction.
METHODS: Sprague Dawley rat models of acute myocardial infarction were established through the ligation of the left anterior descending coronary artery. The rats were divided into five groups:sham operation group was
injected with normal saline;operation control group was injected with normal saline after modeling;SB203580 group was injected with highly selective p38 MAPK inhibitor SB203580 after modeling;erythropoietin group was injected with
erythropoietin after modeling;the erythropoietin+SB203580 group was injected with erythropoietin+SB203580 mixed solution after modeling. The tail vein blood samples were col ected before modeling, 1 day, 1 week, 2 weeks and 4 weeks after modeling, and then enzyme-linked immunosorbent assay was used to detect the levels of interleukin-1β, interlrukin-6 and tumor necrosis factor-α.
RESULTS AND CONCLUSION:There were no significant differences in the levels of interleukin-1β, interlrukin-6 and
tumor necrosis factor-αbetween groups before modeling (P>0.05). There were no significant differences in the levels of interleukin-1β, interlrukin-6 and tumor necrosis factor-αbetween different time points in the sham operation group (P>0.05), and the levels were highest at 1 day after modeling in the other four groups, and then decreased at 4 weeks after modeling (P<0.05). After modeling, the level of serum cytokines in the operation control group were higher than those in the other four groups, while level of serum cytokines in the sham operation group was lower than that in the other four groups (P<0.05);among the three groups intervened with drugs, level of serum cytokines was lower in the
erythropoietin+SB203580 group (P<0.05), while there was no significant difference in the level of serum cytokines between erythropoietin group and SB203580 group (P>0.05). Recombinant human erythropoietin can inhibit the expressions of inflammatory factors (interleukin-1β, interlrukin-6 and the tumor necrosis factor-α) during cardiac
remodeling after rat acute myocardial infarction, and the mechanism of recombinant human erythropoietin for inhibiting the expressions of inflammatory factors may related with the transforming growth factorβ1-TAK1-p38 MAPK signal pathway.

Objective To analyze the changes in the composition of hospitalization of thyroid disease in Lianyungang City from 2002 to 2010,to learn the impact of iodine intake on thyroid disease in Lianyungang City after implementing universal salt iodization (USI),and to get epidemiologic evidence for prevention and control of iodine deficiency disorders scientifically.Methods Medical reports of the patients with thyroid disease were collected from hospitals at county level and above institutions in Lianyungang City from 2002 to 2010.Monitoring results of household iodized salt were also collected from five counties (districts) in Lianyungang City.The changes in the composition of hospitalization of thyroid disease were analyzed,and the relationship between thyroid disease and iodized salt was studied.Results ① A total of 3 559 patients with thyroid disease were enrolled in the study,the ratio between male and female was 1 ∶ 3.36.Mean age was (46.81 ± 14.94) years old and the peak age was from 40 to 60 years old.② Among the hospitalized patients with thyroid disease,the proportion of goiter patients,hyperthyroidism patients,thyroiditis patients,hypothyroidism and other thyroid disorders was 41.64％ (1 482/3 559),40.07％ (1 426/3 559),6.83％ (243/3 559),6.21％ (221/3 559) and 5.25％ (187/3 559),respectively.③In 2002-2010,the hospitalization rate of thyroid disease showed an upward trend (x2 =460.12,P＜ 0.01),and the hospitalization rates of hypothyroidism,goiter,hyperthyroidism,thyroiditis and other thyroid disorders were all increased year by year (x2 =50.54,281.91,85.15,19.51 and 65.01,all P ＜ 0.01).④From 2002 to 2006,among the patients with thyroid disease,the proportion of hyperthyroidism was the highest,and the range of values was from 42.03％ (124/295) to 53.02％ (114/215).Followed by goiter,and the range of values was from 34.55％ (142/411) to 39.25％ (73/186).From 2007 to 2010,the proportion of goiter became the highest,and the range of values was from 42.11％ (232/551) to 49.57％ (291/587).Followed by hyperthyroidism,and the range of values was from 33.05％ (194/587) to 40.47％ (223/551).⑤From 2002 to 2010,the coverage of iodized salt and the consumption rate of qualified iodized salt both increased year by year (x2 =183.75,211.99,all P ＜ 0.01).⑥There were positive correlations between the hospitalization rates of thyroid disease,hypothyroidism,goiter,other thyroid disorders and the coverage of iodized salt,and the consumption rate of qualified iodized salt (rs =0.83,0.93,0.82,0.87,0.83,0.93,0.74 and 0.91,all P ＜ 0.05).⑦There was a positive correlation between the hospitalization rate of hyperthyroidism and the consumption rate of qualified iodized salt (rs =0.72,P ＜ 0.05).Conclusions There are some changes in the composition of hospitalization of thyroid disease in Lianyungang city from 2002 to 2010.Iodine intake may affect the hospitalization rate of thyroid disease.

Objective To evaluate the clinical value of 12-lead Holter monitoring for coronary heart disease (CHD) patients with inferior myocardial ischemia. Methods Ninety-six patients with CHD had accepted coronary angiography (CAG) and 12-lead Holter examination. Results The sensitivity for detecting inferior myocardial ischemia in 12-lead Holter monitoring was 64.91%, the specificity 53.85%, and the positive detecting value 67.20%. In 12-lead Holter monitoring, inferior myocardial ischemia was recorded in 20% of only RCA lesion group, and in 70.37% of double -vessel lesion group, and in 80% of three-vessel lesion group.Conclusion 12-lead Holter monitoring is of some value to evaluate the inferior myocardial ischemia in CHD patients, but other clinical data should be considered.

Objective To study the effect of intracoronary stenting for bifurcational lesions on the related side branches. Methods One hundren and twenty patients with 132 coronary bifurcational lesions were enrolled in the study. Intracornary stents were deployed in the lesions. The incidence of side branch oppression was analysed. Results Twenty-four side branches were oppressed during PCI (14.28%), especially in type Ⅰ and type Ⅳ bifurcation lesions. Conclusion The details of PCI and morphotogical characteristics of bifurcation lesions were the important factors leading the side branch oppression during PCI in bifurcation lesions.

The importance of classics on traditional Chinese medicine in training talents of traditional Chinese medicine was analyzed according to the fact that education of classics on traditional Chinese medicine is increasingly marginalized.After the serial activities of reading classics, learning classics, and using classicsin libraries of colleges and universities of traditional Chinese medicine were described , the advantages and disadvantages of such activities were summarized with certain suggestions put forward for overcoming the disadvantages .