OBJECTIVE:To utilize computer to give better service to clinical practice METHODS:About 4 000 prescriptions of Chinese patent medicines,derived from phamacon criteria:the Chinese traditional patent medicine volume 1～20 published by Ministry Health P R China,were logged into computer and corresponding database was established by using Microsoft Access database By searching the

OBJECTIVETo investigate the combined effects of platelet-derived growth factor-BB (PDGF-BB) and insulin-like growth factor-I (IGF-I) on the expression of integrin (beta3 protein in the periodontal tissues of the compressing side of orthodontic tooth in rats.

METHODSEstablishing orthodontic movement model in Sprague-Dawley rats, which were injected with 10 ng PDGF-BB, 200 ng IGF-I alone or in combination in the buccal submucosal area of the orthodontic tooth. The injection was applied every other day. The experiment continued for ten days and then the rats were sacrificed. The expression of integrin (beta3 protein in periodontal ligament tissues of the compressing side was detected by immunohistochemical techniques.

RESULTSThe expression of integrin (beta3 protein in periodontal ligament tissues of the compressing side of each experimental group was significantly increased compared with that of the control group (P<0.01). Meanwhile the maximum mean optical density value of integrin (beta3 protein expression was attained in the combination group which showed a significant increase compared with the PDGF-BB group (P<0.05) and the IGF-I group (P<0.01).

CONCLUSIONThe combination of exogenous PDGF-BB and IGF- I in orthodontic tooth movement may enhance the expression of integrin (beta3 protein in periodontal ligament cells and PDGF-BB and IGF-I may have a synergistic effect during orthodontic tooth movement.

Animals ; Cells, Cultured ; Fibroblasts ; Insulin-Like Growth Factor I ; Integrins ; Periodontal Ligament ; Platelet-Derived Growth Factor ; Proto-Oncogene Proteins c-sis ; Rats ; Rats, Sprague-Dawley ; Somatomedins ; Tooth Movement Techniques

Objective As the intracranial aneurysm diagnosed by digital subtraction angiography (DSA) examination,the patient's cerebral vessels models of intracranial aneurysms were built by 3D Printer.According to the models,the size,shape,orientation of the aneurysms,as well as the relationship between the parent artery and the branch vessels were analyzed to provide reference for craniotomy.Methods The 11 patients with intracranial aneurysms diagnosed by DSA were prospectively selected in this study from May 1,2016 to June 30,2016.The DSA data of the patients were output in DICOM format,after format conversion and three-dimensional reconstruction by MIMICS software,the selected target regions were modeled by 3D printers in different proportions (1∶1 and 1∶3).Results The cerebral vascular 3D printing models could reflect the shape,size and distribution of the cerebral vascular and orientation of the intracranial aneurysms.It could also show the relationship between the aneurysm and parent arteries along with vascular branches.It was showed that the original size and different amplified model could provide reference for the aneurysm clipping surgery.Conclusion The 3D printing technology can be used into the production of human cerebral vascular models,which can provide a physical model for diagnosis and treatment of intracranial aneurysms,and it can also provide useful reference for preoperative and intraoperative aneurysm clip selection and clamping method decision during the aneurysm clip surgery.

ObjectiveTo observe the effect of modified Zuoguiwan combined with perindopril tert-butylamine tablets on early diabetic kidney disease （DKD） of Qi-Yin deficiency with blood stasis syndrome. MethodA total of 77 patients with early DKD of Qi-Yin deficiency with blood stasis syndrome， who were treated in the Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from september 2020 to november 2021， were randomized into the control group （38 cases） and observation group （39 cases）. The control group received basic treatment and perindopril tert-butylamine tablets， and the observation group was treated with modified Zuoguiwan and perindopril tert-butylamine tablets in addition to the basic treatment. The treatment lasted 3 months for both groups. The symptom scores， blood glucose ［fasting blood glucose （FBG）， 2 h postprandial blood glucose （2 h PBG）， glycosylated hemoglobin （HbA1c）， time in range （TIR）］， serum creatinine （SCr）， urea， estimated glomerular filtration rate （eGFR）， cystatin-C （Cys-C）， serum beta 2-microglobulin （Sβ₂-MB）， and urinary microproteins ［24 h urinary microalbumin （24 h UmAlb）， 24 h micrototal protein （24 h MTP）， urine beta 2-microglobulin （Uβ₂-MB）］ were observed in two groups. ResultThe two groups showed no significant difference in the various indexes before treatment. After treatment， the total effective rate of the control group was 84.2% （32/38）， as compared with the 94.9% （37/39） in the observation group （Z=6.03， P<0.05）. After treatment， the symptom scores were lower than those before treatment in both groups （P<0.01） and lower in the observation group than in the control group （P<0.01）. TIR level was higher （P<0.05） and levels of FBG， 2 h PBG， and HbA1c （P<0.01） were lower than those before treatment in both groups. After treatment， the TIR level in the observation group was significantly increased as compared with that in the control group （P<0.01）. After treatment， the level of Cys-C was lower than that before treatment in both group （P<0.01） and lower in the observation group than in control group （P<0.01）. The level of Sβ₂-MB in both the observation group （P<0.05） and control group decreased as compared with that before treatment. The 24 h UmAlb and Uβ₂-MB of two groups were decreased after treatment as compared with those before treatment （P<0.05）. Moreover， 24 h MTP in observation group （P<0.05） was lower than that before treatment. After treatment， the levels of 24 h UmAlb， 24 h MTP and Uβ₂-MB in observation group were lower than those in control group （P<0.01）， and levels of SCr and eGFR in observation group did not change significantly as compared with those in the control group. ConclusionModified Zuoguiwan combined with perindopril tert-butylamine tablets can reduce blood glucose fluctuations and urinary albumin excretion in early DKD patients of Qi-Yin deficiency with blood stasis syndrome. The efficacy is better than that of basic western medicine.