Objective:To explore the relationship between metabolic score for insulin resistance (METS-IR) and chronic kidney disease (CKD) and albuminuria in the Chinese population.Methods:This cross-sectional study was conducted from January to December 2018 among residents aged 20 to 70 years in ten regions of eight provinces in China; all residents had lived in their region for more than 5 years. Various parameters were measured, included fasting blood glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin (HbA 1c), blood lipids, renal function, urinary albumin/creatinine ratio (UACR), etc. Data of 5 060 subjects meeting the criteria were included in the study. CKD was defined as estimated glomerular filtration rate (eGFR)<60 ml·min -1·1.73 m -2 or UACR≥30 mg/g. Albuminuria was defined as UACR≥30 mg/g. METS-IR was calculated and categorized into quartiles: Q1, METS-IR≤32.19; Q2, METS-IR 32.20-37.10; Q3, METS-IR 37.11-42.58; and Q4, METS-IR>42.58. The correlation between METS-IR and CKD and albuminuria was analyzed by binary logistic regression, and subgroup analyses were performed. Results:There were 1 266, 1 266, 1 265, and 1 263 participants included in Q1-Q4 groups, respectively. With the increase of METS-IR quartile, various parameters increased, including age, fasting blood glucose, HbA 1c, triglycerides, serum uric acid, waist circumference, body mass index, and systolic and diastolic blood pressure, and the proportion of males also increased (all P<0.05). The proportion of patients with CKD and albuminuria increased significantly with the increase in interquartile range (Q) of METS-IR (all P<0.05). Logistic regression analysis showed that for every 1-unit increment of METS-IR, the risk of CKD and albuminuria were both increased by 2% [for both: odds ratio ( OR)=1.02, 95% confidence interval ( CI) 1.01-1.03]. Compared with the lowest METS-IR group (Q1), the ORs for CKD and albuminuria in the highest METS-IR group (Q4) were 1.57 (95% CI 1.17-2.10) and 1.46 (95% CI 1.09-1.96), respectively. In the subgroup analyses, increased METS-IR was significantly associated with CKD and albuminuria among women (CKD: OR=1.62, 95% CI 1.14-2.31; albuminuria: OR=1.53, 95% CI 1.07-2.18), individuals with HbA 1c<7% ( OR=1.64, 95% CI 1.21-2.23; OR=1.55, 95% CI 1.14-2.11), individuals with eGFR≥90 ml·min -1·1.73 m -2 ( OR=1.78, 95% CI 1.27-2.49; OR=1.80, 95% CI 1.28-2.53), and the Chinese Han population ( OR=1.56, 95% CI 1.13-2.17; OR=1.41, 95% CI 1.01-1.96). Conclusions:METS-IR is significantly associated with CKD and albuminuria in a Chinese population. Furthermore, the higher the METS-IR, the higher the risk of CKD and albuminuria.

Objective To investigate and analyze the characteristics of blood physiological and biochemical parameters of Tibetan chickens bred in Guangzhou. Methods Blood samples of Tibetan chickens bred in Guangzhou were collected,and the physiological and biochemical parameters were measured. Results (1)The blood RBC,PLT,PDW, RDW-SD and P-LCR were not significantly different in the males than females(P > 0.05).(2)HCT(P < 0.05), MCHC(P< 0.05),MPV(P< 0.05),HGB(P< 0.01),MCV(P< 0.01)and MCH(P< 0.01)were significantly higher between the males and females.(3)RDW-CV was significantly lower in the blood physiological parameters of males than females.(4)AST,TRIG,ALKP,ALT,Ca,CHOL,CREA,GLU,PHOS and TBIL were not remarkably different in the blood of males than females(P > 0.05).(5)The blood AMYL(P < 0.05)and TP(P < 0.01)were significantly higher in the males than females.(6)The blood ALB(P< 0.01),UREA(P< 0.05), and GLOB(P<0.01)were significantly lower in the males than females. Conclusions The essential data of blood physiological and biochemical indexes of Tibetan chickens bred in Guangzhou are obtained.

The morbidity of inflammatory bowel diseases (IBD) is rising rapidly but no curative therapies to prevent its recurrence. Cell death is crucial to maintaining homeostasis. Necroptosis is a newly identified programmed cell death and its roles played in IBD need to be explored. Necroptosis is mediated by receptor interacting protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL), which resulted in cell swelling, plasma membrane rupture, intracellular content leaking, and eventually cell death as well as the promotion of inflammation. Studies have found that inhibiting necroptosis alleviated IBD in animal models and IBD patients with an increased level of necroptosis in inflammatory tissues, indicating that necroptosis is related to the pathogenesis of IBD. However, due to the complexity in regulation of necroptosis and the involvement of multiple functions of relevant signaling molecules, the specific mechanism remains elusive. Necroptosis may play a vital regulatory role in the pathogenesis of IBD, which provides a new idea and method for further exploring the therapeutic target of IBD.

Objective To investigate the predictive value of labor progress angle(AOP),fetal head descent distance(HPD)and their change rates in the outcome of vaginal trial of cesarean scar uterus.Methods A total of 170 pregnant women who underwent vaginal trial production of scar ute-rus after cesarean section were selected as study subjects,and were divided into successful group and failed group based on the trial production outcomes.Advanced oxidation processes(AOP)and head-perineum distance(HPD)were measured by ultrasound during the active phase of the first stage of labor when the cervix dilated to 4 cm and at 1 hour after the cervix dilated to 4 cm,respectively.The AOP change rate and HPD change rate after 1 hour of progress were calculated.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of AOP,HPD and their change rates in the outcome of vaginal trial production of scar uterus after cesarean section.Delong test was used to compare the differences in area under curves(AUCs).Results Among 170 pregnant women with scarred uterus after cesarean section who were pregnant again,139 cases(success group)were succeed in transvaginal delivery,while 31 cases failed trial delivery,and transferred to cesarean section(failure group).The AOP of the successful group was significantly larger than that of the failed group when the cervix was opened to 4 cm,and the HPD was significantly shorter than that of the failure group(P＜0.05).The AOP change rate and the change rate of HPD of the suc-cessful group were significantly higher than that of the failed group when the cervix dilated to 4 cm and at 1 hour(P＜0.05).The AUC of AOP and HPD in predicting the outcome of vaginal trial de-livery of scar uterus after cesarean section were 0.846 and 0.812 respectively,and AUC predicted jointly by AOP and HPD showed no significant differences compared with AUC predicted separately(P＞0.05).The AUC of the change rate of AOP and HPD in predicting the outcome of vaginal trial delivery of scarred uterus after cesarean section was 0.899 and 0.852 respectively,and the com-bined prediction of AOP change rate and HPD change rate had a higher AUC value than the AUC predicted separately.Its AUC value was higher than that of AOP combined with HPD(P＜0.05).Conclusion The AOP,HPD and their change rates when the uterine orifice expands to 4 cm in the active phase of the first stage of labor have predictive value for the outcome of vaginal trial produc-tion of scarred uterus after cesarean section.

Objective To investigate the predictive value of labor progress angle(AOP),fetal head descent distance(HPD)and their change rates in the outcome of vaginal trial of cesarean scar uterus.Methods A total of 170 pregnant women who underwent vaginal trial production of scar ute-rus after cesarean section were selected as study subjects,and were divided into successful group and failed group based on the trial production outcomes.Advanced oxidation processes(AOP)and head-perineum distance(HPD)were measured by ultrasound during the active phase of the first stage of labor when the cervix dilated to 4 cm and at 1 hour after the cervix dilated to 4 cm,respectively.The AOP change rate and HPD change rate after 1 hour of progress were calculated.The receiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of AOP,HPD and their change rates in the outcome of vaginal trial production of scar uterus after cesarean section.Delong test was used to compare the differences in area under curves(AUCs).Results Among 170 pregnant women with scarred uterus after cesarean section who were pregnant again,139 cases(success group)were succeed in transvaginal delivery,while 31 cases failed trial delivery,and transferred to cesarean section(failure group).The AOP of the successful group was significantly larger than that of the failed group when the cervix was opened to 4 cm,and the HPD was significantly shorter than that of the failure group(P＜0.05).The AOP change rate and the change rate of HPD of the suc-cessful group were significantly higher than that of the failed group when the cervix dilated to 4 cm and at 1 hour(P＜0.05).The AUC of AOP and HPD in predicting the outcome of vaginal trial de-livery of scar uterus after cesarean section were 0.846 and 0.812 respectively,and AUC predicted jointly by AOP and HPD showed no significant differences compared with AUC predicted separately(P＞0.05).The AUC of the change rate of AOP and HPD in predicting the outcome of vaginal trial delivery of scarred uterus after cesarean section was 0.899 and 0.852 respectively,and the com-bined prediction of AOP change rate and HPD change rate had a higher AUC value than the AUC predicted separately.Its AUC value was higher than that of AOP combined with HPD(P＜0.05).Conclusion The AOP,HPD and their change rates when the uterine orifice expands to 4 cm in the active phase of the first stage of labor have predictive value for the outcome of vaginal trial produc-tion of scarred uterus after cesarean section.