Objective To investigate the expression of ?-methylacyl CoA racemase (AMACR,P504S) and p63 in prostate carcinoma tissues and the clinicopathologic significance in the diagnosis of the disease. Methods The expression of AMACR and p63 in 39 cases of prostate carcinoma and 24 cases of benign prostate lesions were examined using immunohistochemical method. The association of the AMACR and p63 expression in prostate carcinoma tissues with the differentiation and clinical staging was evaluated. Results The positive rates of AMACR and p63 were 85%(33/39) and 10%(4/39),respectively,in prostate carcinoma tissues; and those were 21%(5/24) and 88%(21/24),respectively,in benign prostatic hyperplasia. There were significant differences of these values between prostate carcinoma and benign prostatic hyperplasia (P0.05). Conclusions Over-expression of AMACR and under-expression of p63 may be the preliminary incident of the formation of prostate carcinoma,which may induce carcinoma into occurrence and progression.Thus it may be an early diagnostic parameter and a novel target for prostate carcinoma treatment.

Objective To study the advantage and major features of minimally invasive management of neoplasms in the fourth ventricle. Methods Twenty-eight cases of the fourth ventricle neoplasms underwent craniotomy through the cerebellomedullary fissure approach. Postoperative treatment and follow-up information were studied. Results Of the 28 studied cases, total resection was achieved in 23, and subtotal resection in 3. No approach-related complications such as cerebellar mutism, injury of posterior cranial nerves and hemiplegia occured. Conclusion The minimally invasive management of neoplasms of the fourth ventricle by cerebellomedullary fissure approach is safe and effective.

Objective To assess the usefulness of spiral CT examination in detecting the local recurrence and the metastatic lymph nodes of chest in the patients with post-pulmonectomy for central lung cancer.Methods The data of 110 contrast spiral CT of chest in 55 patientswith central bronchial carcinoma post-operation were retrospectively analysed.Results 12 person-time in 9 cases recurred in thebronchial stump or anastomose.The short diameter of lymph nodes in the thorax ≥1 cm was showed in 33 person-time of 26 cases,of them,14 cases was considered as metastasis in combination with the clinical data.Conclusion Spiral CT is the one of the best examination indetecting the post-operation recurrence in the patients with central bronchial carcinoma,but it is still of limitation in evaluating the nature of lymph nodes.

Objective To study the stress distribution on the base of mandibular complete overdenture based on post-core abutment and its su pporting tissues, and to offer experimental foundation and guidance for clinic. Methods 3-D FEM was used to study the stress distribution on the base of mandibular complete overdenture based on post-core abutment and its supporting tissues, calculate the stress values of denture base, mucosality and cortex of bone, then we compared these values with those of natural abutment . Results Base plate of mandibular complete overdenture had stress concentration phenomenon at abutment zone. The stress value of mucosa on bilateral molar teeth alveolar ridge crest was relatively larger. Cortex of bon e mainly bore compressive stress; cortex of bone around the abutment had obvious stress concentration. Conclusion Denture base may fracture at abutment zone; cort ex of bone around abutment relatively bears more stress, so bone absorption may easily arise. Post-core has little influence on stress distribution of denture base and of mucosa ,while it does have some influence on that of cortex of bone.

Objective To analyse the normal helical CT appearances of the bronchial stump or anastomosis after pulmonectomy for central bronchial carcinoma.Methods The available 110 contrast-enhanced spiral CT images in 55 patients undergone different surgical procedures for central bronchial carcinoma were evaluated retrospectively.Results The CT findings of bronchial anastomosis in shape appeared as smooth,concave and convex,sharp angle,obtuse angle,spininess,irregulated or short tube.The thickness of anastomosis was (3.26?1.46) mm.Conclusion Spiral CT can display the bronchial anastomosis clearly after pulmonectomy for central bronchial carcinoma.

Objective To study the stress distribution of mandibular complete overdenture based on post-core abutment with various height of core and its supporting tissues, and to offer experimental foundation and guidance for clinical work. Methods 3-D FEA models of mandibular complete overdenture were set up based on post-core abutment and its supporting tissues; vertical loading was imposed on denture; the stress values of denture and its supporting tissues were calculated and analyzed, with the height of core as 3 mm, 4 mm, 5 mm and 6 mm, respectively. Results With the height of core increasing, the stress in dentine, parodontal membrane, denture base plate and cortical bone increased, while the stress in mucosality hardly changed. Conclusion Under the premise of retention, the height of core should be decreased as much as possible to maintain the health of the tissues.

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Objective:To study the stress distribution of periodontal supporting tissues of mandibular complete overdenture based on post-core abutment. Methods:3-D finite element method (FEM) was employed to investigate the stress distribution of periodontal supporting tissues of mandibular complete overdenture based on post-core abutment, the stress values of periodontal membrane and lamina dura were calculated and compared with those of natural abutment. Results:The values of stress in distal area of abutment were larger than that in medial area. Post-core reduced periodontal membrane stress value in distal area of abutment cervix dentin, as well as that in apical zone, increased the stress value in distal periodontal membrane of the middle part of root, raised the stress value of distal lamina dura of abutment cervix dentin, while reduced the stress value below the cervix dentin. Conclusion:Abutment tends to incline distally. Post-core can influence stress distribution of periodontal membrane and lamina dura and reduce the stress value on root-end.

Objective To evaluate effectiveness of guideline-oriented training for community healthcare workers (HCWs) with The Applied Standards for Hypertension Prevention and Control at the Grassroots to provide guidance to hypertension management in communities. Methods In 2003, four community health-care service centers in Beijing were selected and assigned as intervention (one at urban and one at rural) and control (one at urban and one at rural ) groups, respectively. HCWs in the intervention group received guideline-oriented training based on The Applied Standards for Hypertension Prevention and Control at the Grassroots, while HCW in the control group did not. All HCWs participated in tests of the knowledge of hypertension management using the same questionnaire before and after the training to analyze their changes in awareness scores with a full of 32. Results There were 39 and 33 HCWs in the intervention group and 15 and 16 HCWs in the control group, respectively at urban, and 30 and 33 HCWs in the intervention group and 21 and 22 HCWs in the control group, respectively at rural before and after the training were involved in the tests, respectively. After training, overall knowledge scores of hypertension prevention and control in HCWs in the intervention group at urban increased obviously, with an average score of 26 of 32 ( 81.0% ) after training from 15 of 32 (45. 6% ) before it ( P ＜ 0. 01 ) , with a net increase of 28.5% (9/32), as compared to HCWs in the control group. Those at rural increased to 6. 6% (20/32) after training from 40. 7% (13/32) before it ( P ＜ 0.01 ), with a net increase of 22. 2 percent (7/32), as compared to HCWs in the control group. Their awareness of knowledge of hypertension prevention and control significantly improved, with the most obviously in the target of blood pressure control (51.7% vs. 31.5% ) and principles of pharmaceutical therapy (42. 2% vs. 27. 6% ). Conclusions Guideline-oriented training based on The Applied Standards for Hypertension Prevention and Control at the Grassroots can effectively improve community HCWs' awareness of knowledge of hypertension management and should be widely promoted in communities.

BACKGROUND:At present, liver transplantation is the only way to cure end-stage liver disease, but the complications after transplantation is stil an important factor of affecting the long-term survival of patients who received orthotopic liver transplantation, therefore it is necessary to establish a stable animal transplantation model. OBJECTIVE:To establish rat models of orthotopic liver transplantation. METHODS:After inhalation anesthesia with ether, 204 SD rats were perfused with 2-4℃ Ringer’s solution through the abdominal aorta. In order to reduce warm ischemia of the liver, the liver was not turned over before perfusion. The suprahepatic inferior vena cava was cut off along the phrenic ring after perfusion. No further trimming was needed when dressing, so as not to damage the vena cava. The donor liver was removed and preserved in 4℃Ringer’s liquid. The receptor liver was cut off and alogeneic orthotopic liver transplantation was performed using modified two-cuff method. After transplantation, rats could automaticaly turn over and drink water. Surviving more than 3 days is regarded as a successful transplantation. RESULTS AND CONCLUSION:102 liver transplantations were performed in 204 rats, with 86 rats surviving more than 3 days. The success rate of transplantation was 84%. The results demonstrate that rat models of orthotropic liver transplantation can be constructed successfuly through improving techniques.