OBJECTIVE: To evaluate the status quo and trend of the application of narcotic drugs and psychotropic substances Ⅰ in Yangzhou area.METHODS: The narcotic drugs and psychotropic substances Ⅰ used in 124 hospitals of Yangzhou from 2005 to 2007 were analyzed in respect of consumption sum,DDDs and DDC etc. RESULTS: A total of 13 kinds of narcotic drugs and 4 psychotropic substances Ⅰ were used in the 124 hospitals,and the consumption sum of these drugs increased year on year.Fentanyl remained at the first place in terms of DDDs in each year,Remifentanil Hydrochloride for Injection and Sufentanil Citrate showed an obvious increasing trend in consumption,but the consumption of Bucinnazine Hydrochloride Injection(Tablet),Triazolam and Buprenorphine Hydrochloride Injection decreased to a large extent.CONCLUSION: The use of narcotic drugs and psychotropic substances Ⅰ in the 124 hospitals in Yangzhou area was basically in line with the standard.However,the DDDs of Pethidine Hydrochloride Injection had all along dominated the front place suggesting that clinicians should attach great importance to the standard treatment of cancer pain.

OBJECTIVE:To provide references for hospital pharmacy's culture construction. METHODS: To analyze and pondered over the practice of culture construction in pharmacy department of our hospital. RESULTS: With the organizational culture construction, cohesive force and innovative spirit of our staffs had been improved significantly. CONCLUSION: Organizational culture construction is indispensable for the development of hospital pharmacy.

OBJECTIVE:To evaluate the effect of comprehensive intervention management mode on the use of proton pump inhibitors(PPIs)injection in oncology department of hospital. METHODS:Simple random sampling method was conducted to col-lect 1 457 discharged medical records used PPIs injection in oncology department of our hospital from Jan. 2012 to Dec. 2013(be-fore intervention)and 793 records from Jan. to Dec. 2014(after intervention). The utilization of PPIs injection before and after ad-ministrative intervention,technical intervention and information management was compared. RESULTS:After comprehensive inter-vention,the utilization rate of PPIs injection in oncology department of our hospital decreased from 62.59%(before intervention) to 60.70%,without significant difference(P>0.05). There were significant differences in the proportion of PPIs injection’s con-sumption amount in total medical costs and per capita consumption amount before and after intervention(P<0.05);the utilization rate of Lansoprazole for injection increased from 19.70%(before intervention) to 34.68%,and the Omeprazole for injection de-creased from 34.45%(before intervention)to 25.60%,with significant differences(P<0.05),while there were no significant dif-ferences in the utilization rate of Pantoprazole for injection and Esomeprazole for injection(P>0.05). The proportion of irrational use of PPIs injection decreased from 73.99%(before intervention)to 55.86%,among which,the proportions of no indications of medication,repeated administration and too long duration decreased from 40.01%,17.09% and 26.90%(before intervention)to 32.41%,9.08% and 18.03%,with significant differences(P<0.05),while there was no significant difference in the proportion of inappropriate dose selection before and after intervention (P>0.05). CONCLUSIONS:Comprehensive intervention manage-ment mode can improve the clinical utilization of PPIs injection in oncology department of our hospital to some extent,but the irra-tional use of PPIs injection in our hospital is still not optimistic,which needs further improve intervention to promote its clinical rational use.

Objective To observe the serum inflammatory factors level in patients with obstructive sleep apnea syndrome (OSAS) and coronary heart disease (CHD).Methods Venous blood was collected at 6 AM from 53 natiems with both OSAS and CHD and 37 simple snorers following a full night polysomnography (PSG) test.Serum MMP-9、TIMP-1 test were conducted.Results MMP-9,TIMP-1 level in patients with OSAS and CHD was significantiv higher than that of the simple snorers (P<0.05).Conclusion serum MMP-9 and TIMP-1 level increase in patients with OSAS and CHD.It is suggested that elevated level of serum MMP-9 and TIMP-1 might play an important role in the development of CHD in patients with OSAS.

Objective To investigate the prevention and countermeasures of complications following laparoscopic cholecystectomy(LC) in aged patients.Methods The study was based on a retrospective view of clinical date of 182 aged patients(60～85 years old) who had been treated with LC from January 2000 to October 2006 in this hospital.Co-morbidities existed in 87 patients.The operation was performed under general anesthesia and endotracheal intubation,by using 3-port technique in 137 patients and 4-port technique in 45 patients. Results The LC was successfully completed in 174 patients,with an operation time of 30～100 min and a postoperative hospital stay of 3～10 d.Conversions to open surgery were required in 8 patients due to a difficult dissection(6 patients) or a diagnosis of gallbladder carcinoma(2 patients).No death or serious complications occurred.There were 3 patients with port-site infection and 2 patients with pulmonary infection.Follow-up observations in the patients for 3～12 months revealed no abdominal pain,fever,or jaundice.Conclusions Strictly following indications, properly treating the accompanying diseases,and promptly converting to open surgery are key factors to prevent and reduce complications of LC in aged patients.

Objective To evaluate the role of ?-irradiation with a liquid 188Re-filled balloon for limiting neointimal proliferation. Methods Balloon overstretch injury was performed in carotid arteries of 12 rabbits and randomly assigned to two groups: the control group (n=6) and the radiation group (n=6), using the liquid 188Re-filled balloon designed to deliver 15 Gy at 0.5 mm from the surface of vessel. All animals survived and were sacrificed in 1 week. Histopathologic analysis was performed. Results The intimal area of radiation group was significantly smaller than that of the control group [(0.04?0.06) mm 2 vs (0.16?0.04) mm 2, P

OBJECTIVE:To optimize the management of drug inventory so as to reduce days of drug turnover. METHODS:Depending on the information management system of the hospital,the method of quality control circle was used to analyze the rea-sons of long days of drug turnover,corresponding measures for continuous improvement were developed,and the effects of the ac-tivities in the quality control circle were evaluated on the basis of the rate of achieving the goal and the growth rate of circle mem-bers. RESULTS:In the activities of the quality control circle,based on the factors such as personnel,drugs and the method,corre-sponding measures were developed in respect of permanent applicants for drugs,the upper and lower limits of drugs to be gotten by the applicant,the increase in the frequency of purchase,“zero inventory”management for part of drugs,and the optimization of the generation program of purchase orders,where the percentage of the drugs with the turnover days within 15 d was increased from 72% to over 85%,the rate of achieving the goal was 107.9%. All the circle members significantly grew as to the application of the method of quality control circle,sense of responsibility,initiative,team spirit,communication and coordination,with growth rate of 12%-28%. CONCLUSIONS:The activities of the quality control circle have achieved a good effect in optimizing the drug inventory management of our hospital and increased the percentage of the drugs with the turnover days within 15 d.

Objective To study the anatomical feature s of the retroperitoneal cavity around kidney under laparoscope and to provide ana tomical guidance for laparoscopic surgery. Methods Lapar oscopic renal and ureteral operations were performed on 241 patients (145 men an d 96 women; age range,16-75 years;mean age,45.3 years).Through the videos and ph otographs of these operations,the anatomical features were analyzed.The atlas wa s drawn and surgical access was designed. Results Under laparoscope lateral conal fascia continues from the fascia of quadratus lumborum at its lateral border.This fascia covers posterior lamella of Gerota’s fascia and fuses into transversalis fascia beneath peritoneum. Fusion fascia lies befor e anterior lamella of Gerota’s fascia. It extends laterally and disappears grad ually to the lateral reflexion of peritoneum.The plane between fusion fascia and anterior lamella of Gerota's fascia, the plane between lateral conal fascia and posterior lamella of Gerota’s fascia, the plane before the quadratus lumborum and psoas major, are all vessel-free planes.Lateral border of colon,peritoneum and fusion fascia form a triangle lateral to colon.Fusion fascia,lateral conal f ascia and Gerota’s fascia form a vessel-free triangle. Conclusions Dissection through the vessel-free planes prevents laparoscopic op erations from bleeding and organ injury.Full understanding of the laparoscopic a natomical features of the retroperitoneal cavity around kidney provides the anat omic theoretical basis for laparoscopic operations.

Objective To establish a new atomic fluorescence spectrometry for the determination of As,Hg and Se in human gastric and intestinal juice. Methods The KBH4 solution was used as a reducing agent to generate hydrides of As,Se and metallic vapour of Hg from samples. Results The lineal range of the method was 5.00-80.00 ng/ml for As, 0.10-4.00 ng/ml for Hg, 0.50-5.00 ng/ml for Se respectively. The RSD was less than 6.0%. For As, Hg and Se, the limits of detection were 0.20, 0.01, 0.33 ng/ml respectively, the recovery rates were 98.6%-104.4%, 92.0%-104.0%, 98.5%-100.5% respectively. Conclusion The method is simple, rapid and accurate with satisfactory results.

Objective To study the embryotoxicity and teratogenicity of monocrotophos in mice.Methods Sixty pregnant Kunming mice were randomly divided into four groups,15 in each:three groups were exposed to the monocrotophos at the doses of 0.05,0.10 and 0.20 mg/kg,10 ml/kg through gavage,during the period of organ formation(from 7th day to 16th day),once a day and the control group to distilled water.The pregnant mice were weighted in day of 0,6,12,18,and 20,and were sacrificed on 20th day of pregnancy.The numbers of living,dead and absorbed fetus were counted,and the uterus and placenta were weighted.The deformity examination was conducted.Results The maternal body weight of exposure groups were lower than those of control group in 12,18 and 20 day of pregnancy.With the increased doses of monocrotophos,the weights of pregnant mice showed a downward trend.Compared with the control group,the rates of dead fetus and absorbed fetus increased significantly,and the rates of living fetus,the fetal body weight and body length,tail length and placental weight decreased significantly(P