OBJECTIVE:To provide references for hospital pharmacy's culture construction. METHODS: To analyze and pondered over the practice of culture construction in pharmacy department of our hospital. RESULTS: With the organizational culture construction, cohesive force and innovative spirit of our staffs had been improved significantly. CONCLUSION: Organizational culture construction is indispensable for the development of hospital pharmacy.

OBJECTIVE: To evaluate the status quo and trend of the application of narcotic drugs and psychotropic substances Ⅰ in Yangzhou area.METHODS: The narcotic drugs and psychotropic substances Ⅰ used in 124 hospitals of Yangzhou from 2005 to 2007 were analyzed in respect of consumption sum,DDDs and DDC etc. RESULTS: A total of 13 kinds of narcotic drugs and 4 psychotropic substances Ⅰ were used in the 124 hospitals,and the consumption sum of these drugs increased year on year.Fentanyl remained at the first place in terms of DDDs in each year,Remifentanil Hydrochloride for Injection and Sufentanil Citrate showed an obvious increasing trend in consumption,but the consumption of Bucinnazine Hydrochloride Injection(Tablet),Triazolam and Buprenorphine Hydrochloride Injection decreased to a large extent.CONCLUSION: The use of narcotic drugs and psychotropic substances Ⅰ in the 124 hospitals in Yangzhou area was basically in line with the standard.However,the DDDs of Pethidine Hydrochloride Injection had all along dominated the front place suggesting that clinicians should attach great importance to the standard treatment of cancer pain.

Objective To establish a new atomic fluorescence spectrometry for the determination of As,Hg and Se in human gastric and intestinal juice. Methods The KBH4 solution was used as a reducing agent to generate hydrides of As,Se and metallic vapour of Hg from samples. Results The lineal range of the method was 5.00-80.00 ng/ml for As, 0.10-4.00 ng/ml for Hg, 0.50-5.00 ng/ml for Se respectively. The RSD was less than 6.0%. For As, Hg and Se, the limits of detection were 0.20, 0.01, 0.33 ng/ml respectively, the recovery rates were 98.6%-104.4%, 92.0%-104.0%, 98.5%-100.5% respectively. Conclusion The method is simple, rapid and accurate with satisfactory results.

Objective To study the embryotoxicity and teratogenicity of monocrotophos in mice.Methods Sixty pregnant Kunming mice were randomly divided into four groups,15 in each:three groups were exposed to the monocrotophos at the doses of 0.05,0.10 and 0.20 mg/kg,10 ml/kg through gavage,during the period of organ formation(from 7th day to 16th day),once a day and the control group to distilled water.The pregnant mice were weighted in day of 0,6,12,18,and 20,and were sacrificed on 20th day of pregnancy.The numbers of living,dead and absorbed fetus were counted,and the uterus and placenta were weighted.The deformity examination was conducted.Results The maternal body weight of exposure groups were lower than those of control group in 12,18 and 20 day of pregnancy.With the increased doses of monocrotophos,the weights of pregnant mice showed a downward trend.Compared with the control group,the rates of dead fetus and absorbed fetus increased significantly,and the rates of living fetus,the fetal body weight and body length,tail length and placental weight decreased significantly(P

Objective To evaluate the role of ?-irradiation with a liquid 188Re-filled balloon for limiting neointimal proliferation. Methods Balloon overstretch injury was performed in carotid arteries of 12 rabbits and randomly assigned to two groups: the control group (n=6) and the radiation group (n=6), using the liquid 188Re-filled balloon designed to deliver 15 Gy at 0.5 mm from the surface of vessel. All animals survived and were sacrificed in 1 week. Histopathologic analysis was performed. Results The intimal area of radiation group was significantly smaller than that of the control group [(0.04?0.06) mm 2 vs (0.16?0.04) mm 2, P

OBJECTIVE:To optimize the management of drug inventory so as to reduce days of drug turnover. METHODS:Depending on the information management system of the hospital,the method of quality control circle was used to analyze the rea-sons of long days of drug turnover,corresponding measures for continuous improvement were developed,and the effects of the ac-tivities in the quality control circle were evaluated on the basis of the rate of achieving the goal and the growth rate of circle mem-bers. RESULTS:In the activities of the quality control circle,based on the factors such as personnel,drugs and the method,corre-sponding measures were developed in respect of permanent applicants for drugs,the upper and lower limits of drugs to be gotten by the applicant,the increase in the frequency of purchase,“zero inventory”management for part of drugs,and the optimization of the generation program of purchase orders,where the percentage of the drugs with the turnover days within 15 d was increased from 72% to over 85%,the rate of achieving the goal was 107.9%. All the circle members significantly grew as to the application of the method of quality control circle,sense of responsibility,initiative,team spirit,communication and coordination,with growth rate of 12%-28%. CONCLUSIONS:The activities of the quality control circle have achieved a good effect in optimizing the drug inventory management of our hospital and increased the percentage of the drugs with the turnover days within 15 d.

OBJECTIVE:To evaluate the effect of comprehensive intervention management mode on the use of proton pump inhibitors(PPIs)injection in oncology department of hospital. METHODS:Simple random sampling method was conducted to col-lect 1 457 discharged medical records used PPIs injection in oncology department of our hospital from Jan. 2012 to Dec. 2013(be-fore intervention)and 793 records from Jan. to Dec. 2014(after intervention). The utilization of PPIs injection before and after ad-ministrative intervention,technical intervention and information management was compared. RESULTS:After comprehensive inter-vention,the utilization rate of PPIs injection in oncology department of our hospital decreased from 62.59%(before intervention) to 60.70%,without significant difference(P>0.05). There were significant differences in the proportion of PPIs injection’s con-sumption amount in total medical costs and per capita consumption amount before and after intervention(P<0.05);the utilization rate of Lansoprazole for injection increased from 19.70%(before intervention) to 34.68%,and the Omeprazole for injection de-creased from 34.45%(before intervention)to 25.60%,with significant differences(P<0.05),while there were no significant dif-ferences in the utilization rate of Pantoprazole for injection and Esomeprazole for injection(P>0.05). The proportion of irrational use of PPIs injection decreased from 73.99%(before intervention)to 55.86%,among which,the proportions of no indications of medication,repeated administration and too long duration decreased from 40.01%,17.09% and 26.90%(before intervention)to 32.41%,9.08% and 18.03%,with significant differences(P<0.05),while there was no significant difference in the proportion of inappropriate dose selection before and after intervention (P>0.05). CONCLUSIONS:Comprehensive intervention manage-ment mode can improve the clinical utilization of PPIs injection in oncology department of our hospital to some extent,but the irra-tional use of PPIs injection in our hospital is still not optimistic,which needs further improve intervention to promote its clinical rational use.

0.05),respectively.The average cost was 1 314.8 yuan in Group A versus 3 306.5 yuan in Group B(P

0.05). Propofol increased laser durations of mice in a dose-dependent manner in group P2 and group P3 (P0.05). Compared to group STP2 and group STP3,the laser duration of mice in group P1 and gourp P3 were prolonged (P0.05). Conelusion:PropofoI at subhypnotic doses may have effective analgesic effect to CO, laser induced-pain in a dose-dependent manner.

Objective To compare the effect of three different analgesic techniques on hyperglycemia and stress response to cholecystotomy so as to select a more reasonable analgesic modelMethods Thirty patients after cholecystotomy ,were randomly divided into three groups using three different analgesic techniques:postoperative intravenous morphine patient-controlled analgesia(PCA)(group M),postopetative epidural PCA(group E),and pre-emptive clonidine combined with postoperative epidurral PCA(group P)Blood glucose,plasma levels of stress hormones such as cotisol,insulin,glucagon,epinephrine and norepinephrine were measured at various timesResults All three analgesic techniques produced satisfactory pain reliefHyperglycemiawas inhibited more efficiently in group E and P than in group MThe secretions of stress hormoneswere less suppressed in group M than in other two groupsThe epidural analgesics requirement in group P was lower than in group E(P