Objective To observe the effects of Qingzhi soft capsule(QSC) on improving experimental memory in mice.Methods The model of vascular dementia was made by means of bilateral carotid artery ligation and reperfusion after 8 minutes in mice.Another model of learn and memory disorder was induced by subcutaneous injection of sodium nitrite.The effects of Qingzhi soft capsule on memory disorder were evaluated by step-down test,Y-maze test in mice.Results Compared with sham-operated group,for the mice model of vascular dementia suffered cerebral ischemia and neural cell injury,the step down latency of animal model was shorter(P

Objective To evaluate the reliability of gas sampling from the distal end of the tracheal tube for partial pressure of end-tidal CO2 (PETCO2) monitoring in neonates.Methods A total of 50 fullterm neonates,scheduled for elective abdominal surgery under general anesthesia,aged 1-28 days,weighing 2.55-4.00 kg,of ASA physical status Ⅰ or Ⅱ,were randomly divided into 2 groups (n =25 each) using a random number table:gas samples collected from proximal end of tracheal tube group (group P) and gas samples collected from distal end of tracheal tube group (group D).Epidural catheters of 1 mm in external diameter were used.One end of the catheter was connected to a tube for carbon dioxide sampling,and the other end was inserted into the endotracheal tube and advanced toward the distal hole of the tube.At 15 min of mechanical ventilation,blood samples were collected from the radial artery for record of PETCO2 and for blood gas analysis.Consistency test was performed between PETCO2 and partial pressure of arterial CO2 (PaCO2).Results PET CO2 was significantly lower than PaCO2 in the two groups.There was no significant difference in PaCO2between the two groups.PETCO2 was significantly higher in group D than in group P.Kappa was significantly higher in group D than in group P.Conclusion Gas sampling from the distal end of the tracheal tube is more reliable than gas sampling from the proximal end in monitoring PETCO2 in the neonates.

Objective To estimate the effect of high total cholesterol (TC) on life expectancy in China.Methods Population attributable fractions (PAF) of high TC were calculated in both urban,rural areas and regions,using data related to TC levels from the chronic disease risk factor surveillance in China,2013.Together with PAFs,data related to death registry,demographics,attributable deaths from high TC and its effect on life expectancy,were estimated.Results In 2013,the TC level in Chinese population aged 25 and above appeared as (4.8± 1.0) mmol/L,higher in urban areas [(4.8±1.0) mmol/L] than that in rural areas [(4.7± 1.0) mmol/L)],with the highest in eastern regions [(4.9 ±1.0) mmol/L] and lowest in the central regions [(4.6 ± 1.0) mmol/L].TC level appeared as (4.8 ± 1.0)mmol/L in both sexes.A total of 2.9％ of all the deaths were attributed to high TC (264 998 deaths),among which 89.3％ were caused by ischemic heart disease (236 540 deaths).PAF was seen higher in females (3.7％) than that in males (2.3％),higher in urban (3.4％) than that in rural areas (2.4％),with the highest in eastern (3.7％) and lowest in western regions (2.1％).Mortality that attributed to high TC was 19.6/100 000,higher in females (21.2/100 000) than that in males (18.0/100 000),higher in urban (20.8/100 000) than that in rural areas (18.2/100 000),with the highest in eastern (23.2/100 000) and lowest in western regions (15.6/100 000).In 2013,the loss of life expectancy that caused by high TC was 0.30 year,higher in females (0.35 year) than in males (0.26 year),higher in urban (0.34 year) than that in rural areas (0.28 year),with the highest seen in the eastern (0.36 year) and lowest (0.23 year) in the western regions.Conclusion In 2013,the effect of high TC on life expectancy appeared different between genders,urban and rural areas or regions,with greater impact on females,urban and eastern areas of the country.