Objective To investigate the clinical effect of prophylactic low dose of escitalopram in patients with depressive symp-toms and overall symptoms of Parkinson′s .Methods 40 patients were divided into single drug group used alone Piribedil and com-bined treatment group used Piribedil and escitalopram ,20 cases in each group .Hamilton depression scale (HAMD) ,Parkinson′s disease questionnaire composite score standard (UPDRS) and 39 Parkinson′s disease questionnaire score (PDQ-39) prior treatment were used to assess the changes of the patients′degree of depression and the Parkinson′s overall symptoms .Results Compared with prior treatment ,the HAMD score in single drug group after two weeks treatment had no significant difference (P> 0 .05) , while in combined treatment group ,the HAMD score decreased significantly (P<0 .05) .Compared with prior treatment ,both in single drug group and the combined treatment group ,the UPDRS scores and PDQ-39 rating decreased significantly (P<0 .05) ,but without significant difference between the two groups(P>0 .05) .After six weeks treatment ,Compared with prior treatment ,both in single drug group and combined treatment group ,the HAMD score ,UPDRS score and PDQ-39 score had significantly decreased (P<0 .05) ,but without significant differences between the two groups (P<0 .05) .Conclusion Prophylactic low dose of escitalo-pram may be early control of symptoms of Parkinson′s patients with mild depression .It can also be used to improve the overall symptoms of Parkinson′s patients ,which propose new ideas for the clinical treatment of Parkinson′s disease .

Objective To compare the clinical efficacy of minimally invasive removal of intracranial hematomas and medical con-servative treatment for hypertensive cerebral hemorrhage .Methods A total of 75 patients with hypertensive cerebral hemorrhage were collected and randomly divided into two groups according to the treatments :38 patients treated with conservative medicine and 37 patients treated with minimally invasive removal of intracranial hematomas based on standard drug therapy .Neurological impair-ment and recovery of self-care ability of patients in both groups before and after three weeks and six weeks of treatment were scored by National Institute of Health Stroke Scale (NIHSS) .Changes of diffusion tensor imaging before treatment and after two weeks of treatment were evaluated by fractional anisotropy value (FA) .Results There was no significant difference between neurological im-pairments of the patients in two groups before treatment .But the recovery degree of functional impairment and muscle nerve in min-imally traumatic treatment group was more significant than those in the conservative medical treatment group after treatments . There was significant difference between two groups (P< 0 .05) .Conclusion Minimally traumatic of hematomas is an effective method of treating hypertensive intracerebral hemorrhage .