Objective: To explore high chest resolution CT (HRCT) manifestations of early stage corona virus disease 2019 (COVID-2019). Methods: Chest HRCT findings of 31 COVID-2019 patients were retrospectively analyzed. Results: Chest HRCT showed vary degrees changes of pneumonia within 1 week of onset. Multiple lesions (3 or more lesions) were found in 23 cases. Lesions affected 2 and more pulmonary lobes were observed in 24 cases, while single pulmonary lobe involvement was observed in 7 cases. Multiple ground-glass opacity (GGO) was noticed in 22 patients, while in other 9 cases multiple GGO mixed consolidation were found, all had fuzzy boundaries. The lesions presented at peripheral lungs in 25 cases, while in 6 cases presented at peripheral combined and central lungs. Lesions of irregular morphology were observed in 26 cases, while rounded morphology and sphericity were observed in the other 5 cases. Air bronchogram was noticed in 26 cases, thickening vascular in the lesions were found in 29 case, thickened intralobular interstitium in 24 cases, thickened interlobular interstitium in 6 cases, centrilobular nodules in 2 cases and a small amount of pleural effusion in 1 case. Conclusion: The early chest HRCT manifestations of COVID-2019 have certain characteristics. Combination of clinical history and chest HRCT manifestations is conducive to early diagnosis COVID-2019.

Objective:To study the effect of blood volume feedback control system on improving intradialytic-hypotension (IDH) in maintenance hemodialysis (MHD) patients.Methods:It was a prospective cohort study. Thirty MHD patients with recurrent IDH in the Dialysis Center of the First Affiliated Hospital of Zhejiang University School of Medicine from March 2021 to March 2022 were selected. A self-control study was conducted in MHD patients. The patients were treated with routine hemodialysis in both baseline phase (A1) and reversal phase (A2), while with hemodialysis under the blood volume feedback control system in intervention phase (B). Each phase lasted for 4 weeks (12 hemodialysis sessions). The average occurrences of IDH and IDH-related adverse events (IDH-RAE, stopping dehydration for more than 10 minutes or getting off the hemodialysis machine 10 minutes earlier due to IDH) of each patient between phase A1, B, and A2 were calculated and compared. In a total of 1 080 dialysis records, a logistic regression analysis model was established with age, sex and intervention as independent variables and with the occurrence of IDH-RAE as the outcome.Results:A total of 30 eligible patients were included in the study, including 14 males (46.7%) and 16 females (53.3%), aged 63.0 (56.5, 72.5) years old, with a median dialysis age of 84.0 (37.2, 120.0) months. The average times of IDH in 30 MHD patients decreased from 1.17 (0.83, 1.67) in stage A1 (before intervention) to 0.33 (0.25, 0.58) in stage B (after intervention) ( P<0.05). The frequency of IDH-RAE decreased significantly from 0.29 (0.19, 0.47) in stage A1 to 0.17 (0,0.25) in stage B ( P<0.05). Logistic regression analysis results indicated that the use of blood volume feedback control system reduced the risk of IDH-RAE by 53% ( OR=0.47, 95% CI 0.34-0.64, P<0.001). Conclusions:The application of blood volume feedback control system can effectively reduce the occurrences of IDH and the risk of IDH-RAE in MHD patients.