Objective To observe the clinical effect of small dose mifepristone combined with traditional Chinese medicine in the treatment of uterine gland disease.Methods 76 patients with uterine gland disease were selected,they were divided into the observation group(n =38) and control group(n =38) by using random number table method.The control group was treated with small dose of mifepristone,while the observation group was treated with small dose of mifepristone combined with traditional Chinese medicine.The clinical curative effects of the two groups were compared.Results After treatment,in the observation group,the pain degree of patients [(21.30 ± 6.70) points],influence activity level [(17.30 ± 12.00) points],activity loss [(1.80 ± 0.70) spots] and grades of dysmenorrheal [(0.60 ± 0.20) stages] were lower than those in the control group,the differences were statistically significant (t =5.645,7.023,4.932,3.994,all P ＜ 0.05).After treatment,in the observation group,the uterine volume [(56.20 ± 2.00) mm3],CA125 level [(32.10 ± 2.10) U/mL] were lower than those of the control group (t =4.024,4.413,all P ＜ 0.05).The incidence rate of adverse reaction of the observation group was 7.89％,which was significandy lower than that of the control group,the difference was statistically significant (x2 =14.757,P ＜ 0.05).The patients were followed up for 8 months,the recurrence rate of the observation group was 5.26％,which was lower than 26.32％ of the control group,the difference was statistically significant (x2 =16.678,P =0.000).The menstrual recovery ratio less than or equal to three months of the control group was 81.58％,which was signifi candy higher than 63.16％ of the control group,the difference was statistically significant (x2 =8.484,P =0.003).Conclusion In the treatment process of adenomyosis,the small dose of mifepristone combined with traditional Chinese medicine can alleviate the clinical symptoms,reduce the pain and reduce the volume of uterus,and it has less adverse reaction,safe and reliable,it is worth of clinical application.