Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Humans

Acquired Immunodeficiency Syndrome ; prevention & control ; therapy ; Communicable Disease Control ; Humans

Acquired Immunodeficiency Syndrome ; prevention & control ; Humans

Patients with advanced gastric cancer lose the surgical indications.Chemotherapy can improve the overall survival and quality of life,which is the main treatment option.But there is no standard chemotherapy regimen for the patients with advanced gastric cancer.Since its initial approval,S-1 is widely used in gastric cancer.Several studies were performed to explore combinations of S-1 with other cytotoxic drugs such as platinum,docetaxel,paclitaxel,and irinotecan.All these combinations were found to be promising,with response rates of around 40％-50％ and relatively favorable safety profiles.

Food Contamination ; Humans ; Infant ; Triazines ; toxicity ; Urinary Calculi ; diagnosis ; etiology ; therapy

0.05). But the diffence was significant in other groups (P

Objective To explore the oxidative stress pathogenesis of Parkinson's disease(PD) induced by paraquat in substantia nigra of mice. Methods The model of PD was established by oral administration of paraquat to mice.The spectrophotometry was used to determine the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) and the content of malondialdehyde(MDA) in substantia nigra.At the same time,number of tyrosine hydroxylase(TH) positive neurons in substantia nigra of mice was estimated by immunohistochemistry. Results The activities of SOD and GSH-PX were significantly decreased,and the content of MDA was increased in paraquat-treated mice compared to that of mice treated by saline taken orally(P

uld remarkably inhibit the systemic inflammatory reaction and attenuate the severity of pancreatic injury,and the mechanism may include inhibit the release of TNF-α and IL-1 as well as up-regulate the production of IL-10.

Objective To observe the effect of Ro 20-1724 on social interaction ability of developing rats after repeated ketamine anesthesia.Methods 32 rats with 21 days old were randomly divided into four groups,control group (C group),ketamine group (K group),ketamine + Ro 20-1724 group (K + R group),ketamine + ethanol group (K + E group).Ethanol was used as a solvent of Ro 20-1724.Ketamine 70 mg· kg-1 was intraperitoneal injected,30 min later,to give or not give Ro 20-1724 0.5 mg · kg-1 or equivalent ethanol solvent for once each day for seven consecutive days.Then the rats were fed for three days.On the fourth day after the last administration,the social interaction ability were assessed in all rats.The expression of brain-derived neurotropic factor (BDNF) in hippocampal CA1 region was detected using conventional ELISA.Results Comparing with rats in C group,the time spent on the cage of lifeless body ((60 ± 29) min vs (109 ± 33) min,P ＜ 0.01),unfamiliar rats (103 ±35)min vs (151 ±42)min,P＜0.01;((123 ±34)min vs (184 ±46) min,P＜0.05) and familiar rats (89 ± 25) min vs (140 ± 38) min,P ＜ 0.01) in the social interaction test was significantly less in K group.The time spent significantly prolonged in group K + R,comparing with K group (lifeless body:(94 ± 34) min vs (60 ±29) min,P＜0.01) ;unfamiliar rat 1:(140 ±41) min vs (103 ±35)min,P＜0.05) ;unfamiliar rat 2:(171 ±45)min vs (123 ±34)min,P＜0.01) ; familiar rat:(133 ±35)min vs (89 ±25) min,P＜0.01).And there was no difference between K group and K + N group (P ＞ 0.05).The expression of BDNF in hippocampal CA1 region was significantly lower in K group,comparing with C group ((8.6 ± 2.7) ng/ml vs (11.8 ± 2.4) ng/ml,P ＜0.01) ; and there was a significant increase in K + R group,comparing with K group ((10.1 ± 3.6) ng/ml vs (8.6 ± 2.7) ng/ml,P ＜ 0.05).Conclusion Ro 20-1724 significant rescued social interaction impairment induced by ketamine anesthesia in developing rats.And BDNF in hippocampal CA1 region contribute to the reversal process.

Objective To explore the effect of meta-mood ability training for improving job satisfaction of nurses.Methods A total of 120 nurses were randomized into the observation group and the control group (60 cases in each group).The observation group received meta-mood ability training,while the control group was given routine training.The meta-mood ability and job satisfaction degree were investigated.Results After the intervention,job satisfaction degree and the meta-mood ability level of the observation group nurses were improved than that of the control group.Conclusions The meta-mood ability training is effective in improvement of job satisfaction degree of nurses,as well as increase clinical service quality of nurses.