STAT3, as a member of signal transducers and activators of transcription (STATs) family,which has been recognized as one of the common pathways in cancer cells. STAT3 has been found in many tumor cells that are critical to cell survival, cell proliferation, invasion, angiogenesis and immune evasion.Thus, STAT3 signaling pathway may be a potential therapeutic target for tumor metastasis.

Osteopontin (OPN), a phospborylated and glycosylated protein,is a prominent matrices component of the extracellular matrix of mineralized tissues of bones and teeth, in which they can regulate the formation and growth of hydroxyapatite crystals and influence a variety of cell activities.Recent studies have reported that the expression of OPN is not only correlated with bone formation and bone resorption but also with tumor aggression and metastasis in several types of human cancer,and OPN is even considered to be an index for the diagnosis and prognosis of tumor.This article reviews OPN's role in lung cancer' s infiltration, metastasis and prognosis.

Objective To look into the effects of community intervention measures on blood pressure and hypertension control of the population.Methods Two geographic separated urban communities with the population about 50 000 each were selected as either intervention or control communities in Beijing in 1996.In the intervention community,the primary and secondary prevention on high blood pressure were carried out.And the morbidity and mortality of stroke in both intervention and control populations were monitored.A baseline survey and evaluation re-survey were respectively conducted in 1997 and 2000 covering both intervention and control communities with a cluster random sample of about 800 persons each.Results In the baseline survey,there were no difference between intervention and control communities in six of seven variables including systolic blood pressure(SBP),diastolic blood pressure(DBP),prevalence of hypertension,rate of awareness,therapy,control with SBP 140 and DBP

Purpose:To observe the therapeutic effect of gemcitabine combined with 5-FU for the treatment of advanced cholangiocarcinoma. Methods:21 patients were given gemcitabine and 5-FU intravenously. Results:There was no complete response .The partial response rate was 23.8% and SD,38.1%.12 patients(57.14%) had amelioration of pain and improvement in quality of life.The toxicity was low and tolerable. Conclusions:Gemcitabine combined with 5-FU was an effective and safe regimen for treating advanced cholangiocarcinoma and worthy of further evaluation.

Objective To examine the changes of brain inhibitory neurotransmitters and their precursors with glutamine supplement. The hypothesis is that the supplement of glutamine may delay the fatigue of central nervous system involved in exercise. Methods Rats were suffered with exhaustion treadmill running after different dosages of glutamine supplement of twenty days duration and sacrificed right after the running. Rat free tryptophan (F-Trp), branched chain amino acids (BCAA) in serum and brain, glucose in serum, and 5-hydroxytryptamine (5-HT) in the brain had been quantified with the double blind procedure. Results The results showed that the serum glutamine had no statistical significance among each group. The ratios of F-Trp/BCAA in the serum and brain were lower significantly in large dosage group than the placebo group. The 5-HT level of large dosage group was lower significantly than the other groups, while serum glucose was significantly higher than all the other groups. The ratios of F-Trp/BCAA in the brain were lower significantly in small dosage glutamine supplement rats than the other groups. Conclusion The results suggest that glutamine supplement take advantage of the balance of serum glutamine level. Glutamine supplement improves rat central nerves performance in long time treadmill running, that may due to the decrease of precursor of inhibitory neurotransmitter and itself, and large dosage supplement is more effective than small one.

Objective To evaluated the safety and complications of endovasdcular stenting for symptomatic carotid stenosis with surgical high risk.Methods A series of 11 vessels in 9 patients at surgical high risk were treated by endovascular stenting. The complications during the procedures and postoperative periods were analyzed within one to five months. Results All of the operations were successfully performed without any serious complications. During the follow up period (averaging 6 months), there were no complications of TIAs, stokes and restenoses.Conclusions The study suggests that endovascular stenting may be safe and effective for patients at surgical high risk, but further more study is needed.

Objective To observe the morphological features of the incisive canal in normal anatomy and abnormalities with multi-slice spiral CT (MSCT). Methods MSCT findings of 108 normal subjects and 65 patients with abnormalities involving incisive canal were retrospectively analyzed. Results The normal incisive canal were classified into 3 types according to the morphology of the nasal opening:two openings, short bony crest and one opening (37.04%, 33.33% and 29.63%, respectively), as well as cylinder, Y-shaped and pyramidal (59.26%, 37.04% and 3.70%) in coronal images, and cylinder, pyramidal and fusiform (84.26%, 14.81% and 0.93%) in sagittal images. The maximum diameter of the nasal and palatal opening was (4.67±1.31) mm and (3.51±0.88) mm (P<0.05). The length of the incisive canal was (10.71±1.95) mm, (11.51±1.97) mm in male and (9.91±1.58) mm in female respectively, and gender difference was found (P<0.05). The angle between the posterior wall and the hard palate was (118.51±9.44)°. The upper and lower length from the anterior wall of the incisive canal to the cortical palate was (9.29±1.26) mm and (7.12±1.21) mm, respectively (P<0.05). The manifestations of abnormalities involving incisive canal including enlargement (47.69%), narrowing (46.15%), shortening (3.08%) and interruption (3.08%) were observed. Conclusion The morphology of the incisive canal can be clearly delineated with MSCT and post processing techniques. It is extremely valuable for avoiding potential complications during surgical procedures such as implant placement and helpful to the diagnosis and treatment of abnormalities involving maxillary incisive canal.

Objective To analyze the epidemiological characteristics of imported malaria in Zhangjiagang City. Methods The epidemiological data were collected and retrospectively analyzed for the distribution,cost,and exit-entry mode and port of imported malaria cases in Zhangjiagang City from 2005 to 2015. Results There were 25 imported malaria cases in Zhangjia-gang City from 2005 to 2015,and among them,there were 16 cases of falciparum malaria(64％),6 cases of vivax malaria (24％),and 3 cases of ovale malaria(12％);there was 1 cases of critically ill(4％),there were 8 cases of serious ill(32％) and 16 cases of mild ill(64％). The time of onset was in accordance with the circular distribution. The peak of the incidence of the imported malaria was one month earlier than that of the domestic infection. The seasonal peak was gentle ,and there was also the occurrence in the non-epidemic season in the city. The imported malaria patients were mainly from Africa ,followed by South-east Asia and Oceania. Conclusion The information technology should be applied to improve the key population coverage on the basis of improving the ability of malaria diagnosis and treatment of medical staff and the multi-sector 's cooperation for the im-ported malaria prevention and control in Zhangjiagang City.

[Objective]Exploring innovation in TCM diagnosis and treatment in Zhejiang before modern time,to provide reference for current TCM skil s' heritage and development in Zhejiang.[Method]Using literature research methods, the author sorts out the pre-modern Zhejiang Chinese medicine works. By analyzing and contrasting, the author finds innovative knowledge and information. [Result]Before modern times, the creative technology of TCM diag-nosis and treatment in Zhejiang was characterized with early start, long maintenance and wide range, moreover, in the clinical sections of internal medicine, gynecology, paediatrics, orthopaedics and rhinology, the new theory and new technology continual y came into being on treating rules, methods and diag-nosis. Therefore, it promoted the diagnosis and treatment levels in the whole. [Conclusion] Before the modern times, the creation of Zhejiang diagnosis and treatment technology originated from many doctors ’medical practices; the various diseases sourced from Zhejiang unique geographical and climatic environment offered good stage for generations of doctors to distinguish themselves; and the developed society and material civilization in Zhejiang area provided strong guarantee for Zhejiang doctors to find and invent new diagnosis and treatment technology.

Objective To study the MRI features of nasopharyngeal carcinoma (NPC) in patients who presented with ocular abnormalities. Methods The clinical signs and MRI features of Ⅲ, Ⅳ and/or Ⅵ cranial nerve involvement in 22 cases of histologically proved nasopharyngeal carcinoma were retrospectively analyzed. Results All 22 cases showed perineural tumor spread along the course of Ⅲ, Ⅳ and Ⅵ cranial nerve. Diplopia was the most common sign, occurred in 14/22 patients. The incidence of incomplete palsy of Ⅲ, Ⅳ and Ⅵ cranial nerve were 16/44, 7/44 and 4/44, respectively. There were four types of abnormal MRI findings: cavernous sinus thickening (10/44) and mass ( 16/44), superior orbital fissure enlargement (4/44) and abnormal signals (9/44), thickened oculomotor muscles with obscured adjacent fatty space and abnormal enhancement (10/44). The dynamic contrast enhancement patterns of the masses in cavernous sinus and orbital were the same as that of nasopharynx lesions; all appeared as rapid initial enhancement followed by a plateau phase. Conclusion Oculomotor nerve involvement can be the first clinical signs of NPC, and MRI can show the perineural extension along the Ⅲ, Ⅳ and Ⅵ cranial nerve in NPC.