1.Influence of paraquat on oxidative stress of dopaminergic neuron in substantia nigra of mice
jin-peng, REN ; xiao-jiang, SUN ; yu-ping, JIANG
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(01):-
Objective To explore the oxidative stress pathogenesis of Parkinson's disease(PD) induced by paraquat in substantia nigra of mice. Methods The model of PD was established by oral administration of paraquat to mice.The spectrophotometry was used to determine the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) and the content of malondialdehyde(MDA) in substantia nigra.At the same time,number of tyrosine hydroxylase(TH) positive neurons in substantia nigra of mice was estimated by immunohistochemistry. Results The activities of SOD and GSH-PX were significantly decreased,and the content of MDA was increased in paraquat-treated mice compared to that of mice treated by saline taken orally(P
2.Prevention and cure for eye injury by decayed anchovy fish gas.
Cai-fang YIN ; Ren-dian HU ; Li-ping JIANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(8):495-496
Adolescent
;
Adult
;
Eye Diseases
;
chemically induced
;
prevention & control
;
therapy
;
Fisheries
;
Gas Poisoning
;
etiology
;
prevention & control
;
therapy
;
Humans
;
Hydrogen Sulfide
;
poisoning
;
Male
;
Middle Aged
;
Young Adult
3.Plasmakinetic enucleation of the prostate: the complication and outcome according to the prostate size
Jianming RAO ; Yixin REN ; Jiang HE ; Jinghua YANG ; Ping DING
Journal of Chinese Physician 2016;18(4):557-561
Objective To evaluate surgical complications and outcomes based on prostate size in patients with benign prostatic hyperplasia (BPH) treated with plasmakinetic enucleation of prostate (PKEP).Methods A retrospective review was conducted of PKEP performed in 326 patients with BPH.According to the prostate size on preoperative transrectal ultrasonography measurement,patients were divided into three groups:groupl:<40ml (n =92),group2:40~80ml (n =155),and group3:>80ml (n =79).Intraoperative and perioperative parameters were evaluated.Patient perioperative data and postoperative outcomes were compared.Patients were followed up at 1,3,6 and 12 months after surgery.Early and late complications were recorded.Results There were significant differences among three groups regarding the mean operative time (P < 0.01) and the mean resected tissue weight (P < 0.01).However,enucleation efficiency (P < 0.01) in gm tissue per minute increased significantly as prostate size increased.Mean hemoglobin decrease (P >0.05),mean serum sodium decrease (P >0.05),mean postoperative irrigation time (P > 0.05),mean catheter time (P > 0.05) and mean hospital stay (P >0.05) did not differ significantly among three groups.Three groups had a similar and significant postoperative improvement in international prostate symptom score (IPSS),quality of life (QOL),maximum urine rate (Qmax),and post-void residual urine volume(PVR) independent of prostate size (P < 0.01),but no significant difference was found among three groups during 1,3,6 and 12-month follow-up (P > 0.05).Perioperative and postoperative complications did not depend on prostate size (P > 0.05).Conchsions Although patients with a larger BPH required significantly longer operation time in PKEP,prostate size did not affect perioperative and postoperative complications or micturition improvement.
4.Influence of paraquat on dopamine transporter mRNA and vesicular monoamine transporter2 mRNA in the nigrostriatum of paraquat induced Parkinsonian mice
Ren JIN-PENG ; Ren HUI-MIN ; Jiang YU-PING
Neuroscience Bulletin 2005;21(5):330-334
Objective To investigate the changes of time-course of dopamine transporter (DAT) mRNA and vesicular monoamine transporter2 (VMAT2) mRNA in the substantia nigra of Parkinsonian mice induced by paraquat orally. Methods RT-PCR technique was used to detect the changes of expressions of DAT and VMAT2 mRNA in the substantia nigra of mice after paraquat taken orally for different days. Results The gene expressions of DAT and VMAT2 were decreased gradually two weeks after paraquat. Conclusion In the early stage of paraquat-induced parkinsonian mice, the expressions of DAT and VMAT2 mRNA were decreased, and the degree of reduced expression was more severe with the development of Parkinson disease. DAT and VMAT2 may be involved in the pathogenesis of Parkinson disease.
5.Study in clinical teaching for ophthalmology professional degree graduate students
Tao, JIANG ; Jing, JIANG ; Ren-Ping, WANG ; Yang, ZHOU ; Yuan, WU ; Li, XU
International Eye Science 2016;16(11):2109-2111
According to the clinical teaching for ophthalmology professional degree graduate students, we changed the mode of all pouring, echoing what the books say, to the point to point mode, giving effective teaching, and strengthening the cultivation of the new postgraduates. The point to point mode refers to the teaching content of point to point, the teaching mode of point to point, the teaching guidance of point to point, the teaching assessment of point to point. The content is to be refined, the teaching content is no longer entirely devoted, scripted, but choosing the classic, the key and difficult points. The mode is not limited to teaching, but to training, teaching modes include not only lecture, but also multimedia presentations, on-site teaching, guiding surgery teaching, laboratory, thesis writing training, papers report, clinical thinking and operation basic skill, medical record writing training. The guidance is not limited to time, but to having effect, the teaching guidance is not limited to the tutor, physicians at all levels having the teaching tasks, with different guarantee effect. The assessment is not just scoring, but to practice, the teaching assessment is not a piece of test paper, but the clinical skills practice, medical record writing practice, operation basic skill practice, the clinical process practice, experiment skills practice and thesis writing practice. For the professional degree graduate students, through the point to pointteaching mode, it will lay the foundation for the clinical practice better to develop a good habit of continuous learning, self learning, lifelong learning, for their future knowledge update, for their future career life.
6.3D hemodynamic numerical simulation of carotid artery aneurysm before and after surgery based on CT date.
Guorong REN ; Xiaoqiang CAO ; Dongqing WANG ; Ping JIANG ; Yusheng LI ; Bing PEI
Journal of Biomedical Engineering 2014;31(2):341-346
Hemodynamic situation is an important factor of recurrence of postoperative carotid artery aneurysm. In order to investigate the hemodynamic factors of postoperative carotid artery aneurysm affect carotid artery aneurysm recurrence, we established a 3D finite element carotid artery aneurysm for the preoperative and postoperative periods using the three-dimensional reconstruction techniques. And then we measured the hemodynamic factors of carotid artery aneurysm of preoperative and postoperative by the finite element method. The carotid artery aneurysm model has an accurate and realistic shape; the pressure of the recurrence of aneurysm was reduced significantly after surgery,wall shear stress increased significantly at residual neck, and blood flow velocity increased significantly, which will increase the risk of recurrence. The hemodynamic analysis provides a reference for development of aneurysm clinical treatment programs and prevention of recurrence.
Aneurysm
;
pathology
;
surgery
;
Blood Flow Velocity
;
Carotid Arteries
;
pathology
;
surgery
;
Computer Simulation
;
Hemodynamics
;
Humans
;
Stress, Mechanical
7. Study on the quality control of Zicao ointment
Guiying SHI ; Zhiyin REN ; Ying JIANG ; Ping LU
International Journal of Traditional Chinese Medicine 2018;40(8):738-741
Objective:
Study on the improvement of quality standard for
8.Application of expansion liquid of ropivacaine hydrochloride during endoscopic thyroidectomy
Ping LI ; Yanqing YANG ; Zhiying FENG ; Ren JIANG ; Hong LI ; Weiyi HE ; Hongcun SHA
Journal of Jilin University(Medicine Edition) 2016;42(4):798-802
Objective:To study the effects of expansion of ropivacaine hydrochloride liquid on the postoperative analgesia,sedation, hemodynamic effects and adverse drug reactions of the patients underwent endoscopic thyroidectomy,and to explore its clinical effectiveness and safety. Methods:Forty patients who were to undergo endoscopic thyroidectomy via chest-breast approach were randomly assigned to saline solution group and expansion liquid of ropivacine hydrochloride group (ropivacaine group,n = 20).The mean arterial pressure (MAP )and heart rate (HR)were also evaluated at the following time points:preoperative evaluation (T0 ),before local anesthetic infiltration (T1 ),at the end of the operation (T2 );the blood loss,the operation time,the postoperative drainage,and the hospital duration of the patients in two groups were recorded; the nausea and vomiting,the respiratory depression,the toxicity response,the infection,and the recurrent laryngeal nerve injury during 24 h after operation were recorded.The postoperative pain scores were assessed at extubaltion (T3 ),30 min (T4 ),2 h (T5 ),6 h (T6 ),12 h (T7 )and 24 h (T8 )after extubation using Visual Analog Scale (VAS).The postoperative Ramsay scores were assessed at T3 and T4 .Results:There were no significant differences in MAP and HR at T0 and T1 of the patients between two groups (P >0.05).Compared with saline solution group,the MAP and HR at T2 and T3 of the patients in ropivacaine group were significantly decreased (P < 0.05).There were significant differences in the blood loss,the operation time, the postoperative drainage,and the hospital duration of the patients between two groups (P <0.05).The number of patients required postoperative analgesia and the number patients with nausea and vomiting in ropivacaine group were decreased compared with saline solution group (P <0.05).Compared with saline group,the VAS scores at T3 ,T4 ,T5 ,T6 ,T7 and T8 of the patients in ropivacaine group were significantly decreased (P <0.05);the Ramsay scores at T3 and T4 of the patients in ropivacaine group were also decreased significantly (P <0.05).Conclusion:Expansion liquid of ropivacaine hydrochloride can reduce the stress response during endoscopic thyroidectomy effectively and reduce the postoperative pain and injury induced by operation.
9.Study on the Scientific Research and its Corresponding Strategy for 34 third-grade class A hospitals of Fujian Province between the year 2001 and 2010
Ronghui JIANG ; Nan REN ; Xiaonan WU ; Qiuli CHEN ; Ping LIN ; Xuezhen CHEN ; Liuli DENG
Chinese Journal of Medical Science Research Management 2014;27(1):21-26
Third-grade class A hospitals undertake three tasks-medical service,scientific research and teaching.scientific research is the motivation for third-grade class A hospitals' continuous development and also an important symbol of their medical and academic level.On the purpose of evaluating overall scientific level of such hospitals this thesis analyze the scientific projects and the outcomes of 34 hospitals by using the method of literature research and questionnaire,extracting advantages for scientific research,seeking their problems and coming up with corresponding strategy.have analyzed the achievements we acquired as well as the problems still existing.According to the reality of Fujian Province,some suggestions are coming up with so as to improve the scientific research.