Objective To investigate the clinical effect and the influence to coagulation factor of carboprost tromethamine on the treatment of the patients with postpartum hemorrhage. Methods 60 pregnant women with placenta previa complicated with postpartum hemorrhage from May 2016 to March 2017 were randomly divided into the control group (n=30) and the observation group (n=30). The control group were given oxytocin, the observation group were received carboprost tromethamine. Fibrinogen (FIB), prothrombin time (APTT), prothrombin time (PT) and platelet count before and after surgery in the two groups were analyzed by CA7000 automatic blood analyzer. The effect and coagulation indexes in the two groups were compared. Results The clinical curative rate in the observation group was 96.67% and 93.33% in the control group, the differences had no statistically significant. The amount of hemorrhage in postpartum 2h and 24h and the hemoglobin in postpartum 24h in the observation group were less than those in the control group (P<0.05); There was no significant difference about coagulation indexes between the 2 groups before treatment;The platelet count, PT and APTT levels in the observation group were lower than those in the control group, and the level of FIB was higher than that in the control group (P<0.05); The incidence of adverse reaction was 6.67% in the observation group and 10% in the control group, the difference was not statistically significant. Conclusion Choosing carboprost tromethamine to treat placenta prevail complicated with postpartum hemorrhage has a good curative effect, which is helpful to reduce the amount of postpartum hemorrhage and improve the coagulation indexes, so it is worth popularizing

Objective To explore the effect of different treatments for breast cancer patients.Methods The clinical date of 24 patients with breast cancer were retrospectively analyzed.According to treatment method,24 patients were divided into 2 groups,control group of 12 patients received,and vinorelbine plus cisplatin.Experimental group of 12 patients received gemcitabine plus cisplatin.Both groups were treated for 6 weeks,follow-up in JanuaryFebruary,after treatment the short-term efficacy and toxicity were observed.Results During follow-up compared betwween two groups,after 6 weeks of treatment in patients with overall response rate ( complete response + partial response) are better than 1 week after treatment,the difference was statistically significant( P ＜0.05 ) ;between the two groups compared after treatment,experimental group patients overall efficiency as better than the control group,but had no statistically significant difference( P ＞ 0.05 ).In the control group,Ⅲ + Ⅳ leukopenia,nausea,vomiting and phlebitis rate were relatively high than experimental group,experimental group Ⅲ +Ⅳ thrombocytopenia was higher than control group,the differences were statistically significant( P ＜0.05 ).Conclusion Early application of gemcitabine plus cisplatin in patients with breast cancer could significantly improve,the survival and prognosis,improve patients quality of life,and safe,it's worthy of promoting in clinic.

Medicine, Chinese Traditional ; Terminology as Topic ; Translations

Objective To measure the curvatures of the distolingual root canals of permanent mandibular first molars by cone-beam computed tomography (CBCT). Methods The CBCT was used to collect 230 cases of mandibular first molar distalingual root from 513 patients. The images were created by 3-D reconstruction based on the BECT data. Images were analyzed by NNT image analysis software. Each tooth was captured in clinical (CV) and proximal view (PV) image, and measured by the Schneider method. Results The average curvature of the distallingual canal was (13.27 ± 8.57)° in CV, and (30.96 ± 11.63)° in PV. Most of the distallingual root in the buccolingual view was mild bending or moderate bending , and the proximal view was severe bending. The distal lingual root bending was the most common in the crown third of the root , next in the apical third of the root, in the middle third of the root. Conclusion CBCT is an effective tool for the detection of additional distolingual roots and is a valuable aid for dentists in root canal treatment.

Object To study the chemical constituents of the root of traditional Chinese medicine "Yuanzhi" (Polygala tenuifolia Willd ) Methods Seperation and purification were performed on silica gel, Sephadex LH 20 and ODS CC Their structures were established on the basis of physicochemical and spectral analysis Results Five compounds were isolated and identified as tenuifoliside B (Ⅰ), methyl 3, 4, 5 trimethoxycinnamate (Ⅱ), polygalaxanthone Ⅲ (Ⅲ), 7 O methylmangiferin (Ⅳ) and lancerin (Ⅴ), respectively Conclusion Compounds Ⅱ and Ⅳ were isolated from the plant of Polygala L for the first time and compound V was isolated from P tenuifolia for the first time

Objective:To evaluate the characteristics of fusion using biomimetic n-HA/PA66 interbody cage with rhBMP-2 and discuss the feasibility of it.Methods:Thirty adult female goats underwent C_(3-4) discectomy and interverbral fusion performed with nHA/PA66 interbody cage without rhBMP-2(n=10).nHA/PA66 interbody cage with rhBMP-2(n=10),autogenous iliac crest bone graft(n=10).X ray was carried out at 4 and12 weeks after surgery to evaluate fusion quality.The goats were killed respectively on the 12th week.Nondestructive biomechanical testing for stiffness,un-decalcified histology were performed.Result:The goats in the n-HA/PA66 with rhBMP-2 group and the autogrft group all showed complete fusion at 12th week.there was no statisti- cally significant differience between the n-HA/PA66 with rhBMP-2 group and the autogrft group upon biomechanics,radiography and histomorphology.Conclusion:The interverbral fusion cage with n-HA/PA66 has good hiocompatibifity and osteoconductive ability and it may be good osteoionductive with rhBMP-2,so it was one ideal interbody fusion cage.

The flow distribution of leukocytes in the microvasculature of rat skeletal muscle during hemorrhagic shock was measured by Microcirculation Image Multiple Parameters Computer Analysis System (MIMPCAS). It was found that the change of leukocyte flow distribution had taken place in V3 during hemorrhagic shock as follows: central axial-flowing leukocytes moved slowly, marginated to the vessel wall then started to roll along the wall, and stuck to the endothelium at last. During transfusion blood flow became faster, sticking leukocytes were rushed out to be rolling along the vessel wall and accelerated to enter the central stream. Total leukocyte -endothelium contact time (TLECT), which is a quantitative index for leukocyte endothelium interaction, is calculated, and it was found that TLECT was prolonged in shock state. The results show that it is not enough to increase blood pressure and shear stress to liberate sticking leukocytes, and it is necessary to search for a new approach to decrease the adhesive force between leukocyte and endothelium. Polygonum cuspidatum may not only increase wall shear rate but also decrease the adhesive force.

0.05).Conclusion The intervertebral fusion cage of n-HA/PA66 has good biocompatibility and osteo-conductibility.It may be the ideal interbody fusion cage.

There are some characteristics in the teaching of amateurish adult medical students.As a bridge connecting basic medicine and clinical medicine,pathophysiology is very important in medical education.Aiming at the specialties of amateurish adult medical students,it has very realistic significance for us to explore and reform the teaching methods of pathophysiology,in order to improve the teaching quality and effect.