Combined with the routine work of preventing and treating diseases, the construction of a clean and honest administration in stomatological hospital would be beneficial to raise the administrative staff's awareness of the constructive characteristics of a clean and honest administration in their work belief and methods to enhance the work initiative and effectiveness.

Objective To evaluate the clinical efficacy of salmeterol /fluticasone propionate in the treatment of chronic obstructive pulmonary disease .Methods 107 patients with chronic obstructive pulmonary disease from June 2012 to June 2014 were randomly divided into control group and observation group .Patients in control group re-ceived routine therapy, yet patients in observation group received salmeterol /fluticasone propionate on the basis of routine therapy.The st.George respiratory questionnaire (SGRQ) mark, 6 -minwalktest (6MWT),pulmonary func-tion indexes and drug adverse reactions before treatment and after treatment were observed respectively .Results Af-ter treatment, the lung function index recovery , the SGRQ total score,6MWT of observation group was obviously bet -ter than that of the control group , and the difference had statistical significance (p <0.05).There were no serious adverse reactions occurred in the two groups , and with no statistically significant difference (p >0.05).Conclusion On top of conventional therapy ,salmeterol /fluticasone propionate has good clinical curative effect and high safety for treating COPD,and so it is suitable for long -term and sustained treatment .

Objective To evaluate the effects of geraniol(GOH) on neointima hyperplasia in rat carotid artery balloon injury model, and explore the potential molecular mechanisms associated with this effect. Methods Totally 20 male Sprague-Dawley (SD) rats were randomly divided into sham operation group (without balloon injury), control group (with balloon injury), low concentration group (with 50 mg/kg GOH intervention after balloon injury) and high concentration group (with 200 mg/kg GOH intervention after balloon injury). The intima to media (I/M) area ratio of neointima was measured by hematoxylin- eosin (HE) staining. The expression of proliferating cell nuclear antigen (PCNA) was measured by immunohistochemical staining at 14th day after operation. As the marker of oxidative stress, the levels of 8-hydroxy-2’-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) were measured by enzyme linked inmmnosorbent assay (ELISA). Results The I/M ratio, IOD, 8-OHdG and MDA values were increased in control group compared with those of sham group. The I/M ratio, IOD and 8-OHdG values were reduced in low concentration group compared with those of control group. But there was no significant difference in MDA level between low concentration group and control group. The I/M ratio, IOD, 8-OHdG and MDA values were significantly reduced in high concentration group compared with those of control group, which showed a more significant inhibitory effect than that of low concentration group (P<0.05). Conclusion GOH could attenuate balloon iniury induced neointima hyperplasia, which might be related to its effect on inhibiting expression of PCNA and decreasing oxidative stress.

Long noncoding RNA (lncRNA) refers to RNA transcripts with more than 200 nucleotides in length, which plays regulatory roles directly in the form of RNA. Their functions are affected by their secondary structures, post transcriptional modification and so on. LncRNA can be classified to various subtypes with complicated mechanisms. In human-induced-pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), dynamic expression of some lncRNAs is detected during the neuronal differentiation, and a series of lncRNAs associated closely with the development process of the central nervous system (CNS) are found. This review summarizes the molecular biological properties of lncRNA and their regulatory functions in the development of the CNS, which is helpful to reveal the mechanisms of the pathogenesis and progression of certain neurological diseases and results in innovation of their diagnosis and treatment.

Objective To investigated the analgesic effect of processed Aconiti tuber(PAT) in rats with a sciatic nerve chronic constriction injury(CCI) .Methods The study was conducted in two parts. CCI model was developed with four ligatures placed around the right sciatic nerve and tied without obstructing the blood supply of the nerve. In part Ⅰ, forty rats were randomly divided into five groups(n = 8) . In group Ⅰ normal saline 1 ml , In group Ⅱ-Ⅴ PAT 0.5 ,1, 2 ,or 4 g/kg was administered orally 14 days after CCI respectively. In part Ⅱ , thirty-two rats were randomly divided into four groups (n = 8) . In group Ⅰ oral normal saline 1 ml, in group Ⅱ oral PAT 2 g/kg, in group Ⅲ oral PAT 2 g/kg + intraperitoneal nor-binaltorphimine (nor-BNI) 2 mg/kg, in group Ⅳ oral PAT 2 g/kg + intrathecal nor-BNI 100 ?g was administered 14 days after CCI. As indicators of mechanical and heat hyperalgesia, the paw withdrawal pressure threshold (PWPT) in response to a graded pressure stimulus with a filament and the paw withdrawal latency (PWL) in response to radiant heat were measured in both hind paws before and after drugs administration.Results In part Ⅰ, in group Ⅲ-Ⅴ PWL was prolonged significantly and in group Ⅳ - Ⅴ PWPT were significantly increased compared with those in group I . There was no significant difference in PWL and PWPT between group Ⅰ and group Ⅱ . In part Ⅱ , in group Ⅲ, Ⅳ PWPT and PWL were significantly lower than those in group Ⅱ . There was no significantly difference in PWL and PWPT between group Ⅰ and group Ⅲ, Ⅳ . Conclusion In rat with neuropathic pain processed Aconiti tuber exerts analgesic effect via the spinal ?-opioid receptor activation.

0.05 ). Conclusion The NPT test is simple and practical, and its diagnostic accuracy is comparable to that of the combined test. The NPT test should be used as an examination of choice for the primary etiological diagnosis in ED after trauma.

OBJECTIVE:To prepare hydrocortisone lotion and establish its quality control method. METHODS: The lotion was prepared with hydrocortisone, and the content of hydrocortisone was determined by ultravidet spectrophotometry. The stability of the prepartion and its skin stimulus were investigated as well. RESULTS: The preparation was colorless limpid liquid and up to the standard specified in Chinese Pharmacopeia (2005 Edition) in the related test. The linear range of hydrocortisone was 5.0～30 ?g?mL-1(r=0.999 0) and the average recovery was 100.09% (RSD=0.17%). After storing for 3 and 6 months, respectively, no obvious change was noted for the preparation. The skin stimulus experiment showed that it caused no side effects such as erythema on skin or edema etc. CONCLUSION: This lotion is simple in preparing process, and its quality is stable and controllable.

OBJECTIVE:To standardize the utilization management of medical appliance in rural medical institutions and improve the supervision efficiency.METHODS:Electronic supervision of medical appliance in rural medical institutions was performed in terms of purchase,acceptance and utilization of medical appliance using computers and health information network.RESULTS & CONCLUSIONS:The implementation of electronic management of medical appliance in rural medical institution achieved initial success to standardize purchase channel and utilization of medical appliance and improve efficiency and level of supervision.Electronic supervision is worth of popularizing in national medical institutions while it is deficient in electronic supervision network joint,matching measures and systems,etc.

This study was set up to observe the changes in stress and immune functions in upper abdominal surgery after general anesthesia.In thirty elective upper abdominal operation patients,general anesthesia was induced with propofol,fentanyl,scoline and maintained with isoflane and atrumium. Catecholamines(CA),cortisol,interleukin-2(IL-2) and soluble interleukin-2 receptor(sIL-2R) were measured before anesthesia,after induction of anesthesia,at the end of operation,and on the first and third postoperative days.The results showed that epinephrine(E),norepinephrine(NE) concentration increased at the end of operation and on the first postoperative day(P

OBJECTIVE:To analyse compound pharmaceutical preparations by the signal conversion combined with multicomponent calibration methods METHODS:One-order derivative spectrum data was obtained by one-order derivative conversion On the basis of this,we combined them with the MLR method and PLS method to determine the contents of metrozole and chloromycetin in co metrozole injection RESULTS:The labelling quantity and RSD(n=5) were:metrozole 99 6%,0 11%;chloromycetin 99 3%,0 20% by derivate-MLR;The labelling quantity and RSD(n=5) were:metrozole 97 5%,0 43%;chloromycetin 94 6%,0 89% by derivate-PLS respectively CONCLUSION:One-order derivative spectrum signals aplied to the MLR method is better than the D1 PLS method