1.Research progress on the relationship between HSP27 and carcinoma
Cancer Research and Clinic 2009;21(6):430-431
Heat shock protein 27 (HSP27) is an important small molecular of heat shock protein. It is extremely intimated with carcinoma and it is connected with carcinoma cell drug resistance, radiosensitivity, prognosis of tumor patient. A brief of HSP27 with all of them were reviewed.
2.Construction of Information Resource Catalogue System in Medical Field
Chinese Medical Equipment Journal 2003;0(12):-
Objective To analyze and explore the construction of information resource catalogue system in medical field for information exchange and sharing.Methods Based on analyses of challenges faced and service models of the catalogue system,the functions of the system were determined.Results The functional modules of the catalogue system were designed.Conclusion It is necessary to establish information resource catalogue system for multi-fields,large-scope information exchange & sharing,as well as cooperation between medical facilities and cost decrease of information acquisition.
5.Establishment of Emergency Management Information System in Area Nuclear and Radiation
Wei LI ; Qisheng JIANG ; Fengsheng LI
Chinese Medical Equipment Journal 2003;0(11):-
Objective To discuss the establishment of emergency management information system in area nucleus and radiation. Methods Starting with the challenge in the nucleus and radiation work, according to the demand of the whole frame of the nucleus and radiation emergency management system and combining with the characteristic of nucleus and radiation emergency, the author devised the whole frame of the nucleus and radiation emergency management system, and designed the databank and operation application system based on nucleus and radiation emergency management system. Results The author designed the emergency management information system facing area nucleus and radiation, which can provide technique support for the nucleus and radiation, such as forecast and early -warning, monitor and control, emergency command, assistant decision and so on. Conclusion Nucleus and radiation emergency is the important part of the country emergency management system. It is an important promise for the persistence development of the nucleus enterprise to build a safe and perfect nucleus and radiation emergency management system. It is also the key question to the country safety and social stability.
6.Public Sentiment & Panic Degree Analysis System for Medical Emergency
Wei LI ; Yan LI ; Qisheng JIANG
Chinese Medical Equipment Journal 1989;0(01):-
Objective To design a public sentiment & panic degree analysis system for medical emergency.Methods Based on public sentiment monitoring through Internet,web-based data-mining technology was applied to measurement of public panic.Results A new idea for monitoring of public sentiment & panic degree during medical emergency was put forward.Conclusion Medical emergency results in not only material loss,but also public panic,and Internet makes public panic spread rapidly.The public sentiment & panic degree analysis system can provide decision support when the authorities perform emergency management.
7.Clinical analysis of intravitreal injection of Conbercept combined with 532-laser treating Coats disease in adulthood
Li, JIANG ; Jin, LI ; Wei, PENG
International Eye Science 2017;17(7):1356-1358
AIM: To analyze clinical observation and the efficiency of intravitreal conbercept combined with 532-laser on Coats disease in adulthood.METHODS: This was an retrospective analysis.Six eyes from 6 patients(5 males and 1 female) with coats disease diagnosed by fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) were enrolled.Before the injection, best-corrected visual acuity (BCVA) of early treatment of diabetic retinopathy study (ETDRS), non-contact tonometer, ophthalmoscope, fundus photography, FFA, and OCT were examined.The initial average visual acuity (ETDRS letters) were 51.17±15.15.The initial average central retina thickness (CRT) was 303.30±107.87μm.All affected eyes were treated with intravitreal conbercept 0.05mL (10mg/mL) combined with 532-laser.Patients were followed up for 6 to 12mo, with a mean duration of 7.33±1.26mo.Post-treatment BCVA were compared with baseline using repeat analysis.RESULTS: The mean BCVA showed significant improvement during 1 wk, 1, 3mo post-treatment and the latest follow up (P<0.01).During the latest follow up, the mean BCVA was obviously improved in 3 eyes (50%), improved in 2 eyes (40%), stable in 1 eyes (10%).Likewise, the subretina fluid absorption of different levels.No adverse events such as secondary retinal detachment or endophthalmitis were found during the follow-up.CONCLUSION: Coats disease in adulthood more likely to have lower symptom and have a better response on treatment.Intravitreal conbercept combined with 532-laser significantly improve visual acuity and absorb the subretina fluid.
8.Effect of microRNA-205 on proliferation of laryngeal carcinoma cell line Hep-2.
Xiaotian LI ; Wei LI ; Xuejun JIANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(9):831-834
OBJECTIVE:
To study the effect of microRNA-205 (miRNA-205) on proliferation of laryngeal carcinoma cell line Hep-2.
METHOD:
The expressions of miRNA-205 in 27 cases laryngeal carcinoma tissues and adjacent normal tissues were detected by Real-time quantitative PCR, the expression of PTEN protein was detected by Western blot. The expressions of PTEN were detected by Western blot after miRNA-205 inhibitor or miRNA-205 mimics was transfected into Hep-2 cells and Hep-2 cells proliferation was measured by CCK-8 kit.
RESULT:
The expression level of miRNA-205 was significantly higher in laryngeal carcinoma tissues than in adjacent normal tissues (P < 0.01), and the expression of PTEN protein was lower in laryngeal carcinoma tissues than in adjacent normal tissues (P < 0.01). The proliferation rate of Hep-2 cells was decreased significantly and the expression of PTEN protein in Hep-2 cells was increased significantly after miRNA-205 inhibitor was transfected into (P < 0.01), and the proliferation rate of Hep-2 cells was increased significantly and the expression of PTEN protein in Hep-2 cells was decreased significantly after miRNA-205 mimics was transfected into (P < 0.01).
CONCLUSION
miRNA-205 might promote the proliferation of Hep-2 cells by regulating the expression of PTEN.
Cell Line, Tumor
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Cell Proliferation
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Humans
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Laryngeal Neoplasms
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metabolism
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pathology
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MicroRNAs
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antagonists & inhibitors
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metabolism
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PTEN Phosphohydrolase
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metabolism
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Transfection
10.Diagnosts and treatment of 8 cases of familial papillary thyroid microcarcinom
Wei LI ; Yangshen JIANG ; Jingjing ZHANG
Chinese Journal of Postgraduates of Medicine 2008;31(20):38-40
Objective To summarize the clinical characteristics.diagnosis and treatment of familial papillary thyroid microcarcinoma(PTMC).Method The clinical data of 8 cases of familial PTMC admitted from October 2004 to January 2005 were analyzed.Results All patients were followed-up during 9 to 13(mean 10.8)months. No one suffered recurrence and dead. PTMC was found in 2 cases incidentally from thyroid specimens removed for supposed benign disease, another 6 cases were doubtful of cancer before operation and were identified by frozen section.Upper deep cervical lymph nodes were involved in 2 eases with lymph node metastasis. Lymph node metastasis in eases of multifoeal cancer in the affected lobe or of both lobe was significantly higher than those in monofoccal cancer in uni-lobe. Conclusions Most of the PTMC are found among the benign nodules during operation or within the pathological specimens,and familialPTMC are rather rare. Careful palpation,color Doppler uhrasonography, exploratory operation and frozen section are very important factors to heighten diagnosis of PTMC. Lobectomy is the routine radical operation.