Objective:To explore the necessity of monitoring polysomnography (PSG ) in snoring children.Method:The PSG were monitored in 162 children with snoring or apnea.Acording to results of PSG,162 cases were separated into two groups:group obstructive sleep apnea hypopnea syndrome(OSAHS) and group primary snoring(PS),monitoring data including:apnea hypopnea index(AHI),snoring index(SI),lowest oxygen saturation(LSaO_2) and time of SaO_2<0.9,all data were undertaked statistical analysis. Result:In all 162 snoring cases,150 cases(92.6%) belong to group OSAHS,12 cases(7.4%) belong to group PS;Differences of data of age,sex and body mass index(BMI) are not significant but that of AHI,SI,LSaO_2 and time of SaO_2<0.9 are significant(P<0.05).Conclusion:It's necessary to monitor PSG in snoring children for early diagnosis and correct treatment to avoid disadvantage of OSAHS.

Orthokeratology is a kind of rigid contact lens which have reverse geometric desi, with higher oxygen permeability and security.Overnight wearing of orthokeratology can decrease the central corneal curvature and increase peripheral corneal curvature by flatting the central department of corneal, thus reduce the refraction of myopia.Through a period of time of wearing orthokeratology lens, patients can obtain good eyesight without frame glasses.Insisting on wearing orthokeratology lens can control the development of myopia.Orthokeratology is widely applied in the control of juvenile myopia, so we need scientific evaluation system to measure the visual quality after wearing orthokeratology lens.Here are the methods that used to evaluate the visual quality after wearing orthokeratology lens.

AIM:To evaluate the effect of rigid gas permeable ( RGP ) lens on the tear film and the visual quality in adolescents with a double-pass system.
METHODS:This was a prospective study comprised 23 myopia patients ( 39 eyes ) wearing rigid gas permeable contact lens ( RGP ) between Jun. 2015 and Aug. 2015 in the Department of Ophthalmology of Jinling Hospital. Uncorrected visual acuity ( UCVA ) , sphere refractive, cylinder refractive, Schirmer I test, tear film break-up time ( BUT ) , the visual quality and the tear film quality with OQAS II were obtained before and 1wk, 1, 3, 6mo after wearing. The data was analyzed using t-test and One-way.
RESULTS:The UCVA in before and after 1wk, 1, 3, 6mo were 0. 23±0. 10, 0. 81±0. 23, 0. 99±0. 11, 1. 01±0. 09, 0. 95±0. 14, the difference was statistically significant ( F=723. 36, P<0.01). The sphere in before and after 1wk, 1, 3, 6mo were (-2. 83±1. 34) D, (-0. 63±0. 82) D, (-0. 12±0. 20) D, (-0. 03±0. 10 ) D, (-0. 10±0. 30 ) D respectively, the difference was statistically significant (F=107. 01, P<0. 01). The refractive cylinder in before and after 1wk, 1, 3, 6mo were (-0. 12±0. 21) D, (-0. 13±0. 22) D, (-0. 12±0. 21) D, (-0. 14±0. 26) D, (-0. 21±0. 27) D respectively, there was no significant difference before and after wearing RGP (F=2. 58, P>0. 05). Schirmer I test showed no statistically significant difference before and after wearing RGP ( F=4.88, P>0. 05). The stability of tear film was reduced after wearing RGP, and the difference was statistically significant (F=135. 11, P<0. 01). The modulate transfer function ( MTF ) cut- off frequency was reduced after wearing RGP, the object scatter index ( OSI ) was increased after wearing RGP, and the difference was statistically significant, the tear film quality OSI was increased after wearing RGP, and the difference was statistically significant (F=6. 16, 19. 23, 10. 62, P<0. 01).CONCLUSION:The UCVA is significantly increased after wearing RGP. However, there was no significant change in the base-line of tear secretion, but BUT is significantly reduced after wearing RGP. The stability of the tear film is reduced, which can lead to a decline in visual quality.

Objective To explore whether theophylline has clinic effects of treatment on bronchiolitis in children. Methods 128 children with bronchiolitis in our hospital were divided into the experiment and the control at random, in the meantime, grouped into the severe and the mild according to their condition. The children in the control were used traditional methods. The children in the control were taken theophylline, as well as used traditional methods. All patients in our hospital were checked up pulmonary function, alkyladenine glycosylase in trachea secretion, serum interleukin 8, cytotaxonomy in trachea secretion on time, after the third day and the 7th day. Results The pulmonary function and cytotaxonomy of the patients in the experiment were more improvement than that of the control. Their alkyladeniue gtycosylase in trachea secretion and serum interleukin 8 were very lower than that of the control. The cure rate in the mild and the severe of the experi-ment were higher than that of the control. Conclusion Administrating theophyUine by oral can improve the pulmonary function, relax a block of the small trachea, and raise the cure rate of patients with bronchiolitis.

Recent studies reported that thymoquinone (TQ), a component derived from the medicinal spice Nigella sativa (also called black cumin), exhibited inhibitory effects on cell proliferation of many cancer cell lines. This study was performed to investigate the anti-metastatic effect of thymoquinone on the pancreatic cancer in vitro and in vivo. The results showed that thymoquinone suppressed the migration and invasion of Panc-1 cells in a does-dependent manner. To investigate the possible mechanisms involved in these events, Western blotting analysis was performed, and found that thymoquinone significantly down-regulates NF-kappaB and MMP-9 in Panc-1 cells. In addition, metastatic model simulating human pancreatic cancer was established by orthotropic implantation of histologically intact pancreatic tumor tissue into the pancreatic wall of nude mice. And administration of thymoquinone significantly reduced tumor metastasis compared to untreated control. Furthermore, the expression of NF-kappaB and MMP-9 in tumor tissues was also suppressed after treatment with thymoquinone. Taken together, the results indicate that thymoquinone exerts anti-metastatic activity on pancreatic cancer both in vitro and in vivo, which may be related to down-regulation of NF-kappaB and its regulated molecules such as MMP-9 protein. Consequently, these results provide important insights into thymoquinone as an antimetastatic agent for the treatment of human pancreatic cancer.

AIM: To evaluate the efficacy of phacoemulsification and intraocular lens implantation surgical intervention of complicated cataract in patients with uveitis.
●METHODS:Retrospective study. A total of 57 cases (57 eyes ) with complicated cataract with uveitis were involved in the study from Jan. 2015 to Dec. 2015. All cases underwent phacoemulsification and intraocular lens implantation surgery successfully. The postoperative reaction, effect, complications and so on were retrospectively analyzed after phacoemulsification and intraocular lens implantation surgery. The date of visual outcome was analyzed using Non - parametric Wilcoxon test.
●RESULTS: lris were bleed in 21 eyes ( 37%) , 4 eyes ( 7%) with posterior capsule rapture and posterior chamber intraocular lens was not implanted in 4 eyes ( 7%) . The uncorrected visual acuity ( UCVA ) was significantly increased after surgery. The UCVA of 8 eyes (14%) were 0. 1 or better before surgery, and the UCVA of 42 eyes (74%) were 0. 1 or better 3mo after surgery, the difference was statistically significant ( Z=23. 42, P<0. 001). The corneal edema (17 eyes, 30%), uveitis (2 eyes, 4%) and intraocular hypertension ( 1 eyes, 2%) were appeared in postoperative 1d. The corneal edema (3 eyes, 5%) was appeared in postoperative 1wk. The uveitis ( 1 eyes, 2%) was appeared in postoperative 1mo. The corneal edema (1 eyes, 2%), uveitis (2 eyes, 4%) , intraocular hypertension ( 1 eyes, 2%) and after-cataract ( 3 eyes, 5%) were appeared in postoperative 3mo.
● CONCLUSION: The phacoemulsification combined intraocular lens implantation surgical intervention of complicated cataract in patients with uveitis has good effect and fewer complications.

Objective To study the therapeutic effect of EUS-guided biliary drainage (EUS-BD) on patients with malignant obstructive jaundice when ERCP failed.Methods From January 2014 to January 2016,all patients with malignant obstructive jaundice during hospitalization underwent EUS-guided biliary drainage (group A,36 cases) or PTCD treatment (group B,30 cases) by draw after failed ERCP.Operation success rate,liver function recovery time,complication rates,length of hospital stay and hospital costs were observed and compared.Results There was no significant difference in the operation success rates between two groups [94.44％ (34/36) VS 86.67％ (26/30),P＞0 05)].And there were significant differences in liver function recovery time (25.79± 6.48 d VS 30.24 ± 8.49 d),incidence of complications [5.56％ (2/36) VS 23.33％ (7/30)],length of hospital stay (21.54±4.73 d VS 25.68 ± 8.56 d) and hospitalization costs (23.5±8.4 thousand yuan VS 32.8±6.5 thousand yuan,P＜0.05).Conclusion EUS-guided biliary drainage could be the first option for its noninvasiveness and efficacy,when ERCP failed in patients with malignant obstructive jaundice.

Objective To compare the effects of SFE - CO2 extraction and steam- distillation extraction for the extraction of volatile constituents from Huoxiang Zhengqi prescription. Methods The recovery rate of the volatile constituents and GC- MS method were used to compare the two different extraction methods. Result The recovery rate of volatile constituents was 0.45 % when extracted by steam distillation for 5 hours and 2.40 % by SFE - CO2 extraction for 3 hours. A large amount of peaks were detected in the SFE - CO2 extraction, while few compounds could be detected in the steam distillation extract 15 minutes later. Conclusion SFE - CO2 extraction method is a better method for the extraction of volatile constituents from Huoxiang Zhengqi prescription,with higher recovery rate, obtaining more ingredients and costing less time compared with those by steam distillation extract method.

Objective:To examine the adiponectin level in gingival crevicular fluid(GCF)in patients of chronic periodontitis with dia-betes mellitus type 2.Methods:20 patients of diabetes mellitus type 2 with chronic periodontitis(DM&CP),20 of periodontitis(CP) and 20 health subjects(H)were included.The periodontal indexes (SBI,PLI,PD and AL)were measured,GCF samples were quan-tified by periotron 8000,the adiponectin content in GCF was tested by adiponectin ELISA kit.The relationship between the adiponectin level in GCF and the periodontal indexes of the DM&CP patients was analyzed statistically.Results:The adiponectin level in GCF in group DM&CP was significantly lower than that in the other 2 groups(P <0.05).The adiponectin levels in GCF in group CP and H were not statistically different.The adiponectin level in GCF was negatively correlated with PD and AL(P <0.05),but had no correlation with SBI and PLI(P >0.05).Conclusion:Decrease of adiponectin in GCF may play a role in the development of DM&CP.

A total of 12 775 SSRs were identified from Scutellaria baicalensis Georgi genomic database, accounting for 2.56% of the total genomic sequences. The result showed that S. baicalensis SSRs were based on 68.32% dinucleotide and 18.63% trinucleotide repeats; CT/GA and TTC/GAA were predominant in the dinucleotide motifs and the trinucleotide motifs respectively. Nine primers were selected to produce highly reproducible SSR bands and were used in studying the genetic diversity of S. baicalensis, 50 individuals from ten populations. 68 SSR polymorphic loci were detected, these loci were polymorphic and displayed 4 to 12 alleles per locus with a mean number of 7; the effect number of alleles was 3. Expected heterozygosities were 0.6 and were far more greater than the average in dicotyledonous plants. PIC (polymorphism information content) was 0.72, Shannon's information index was 1.32, these all proved that S. baicalensis had a high genetic diversity in general. Genetic differentiation among population Gst was 0.131, genetic variation among population accounted for 13.1% and genetic variation within population accounted for 86.9%. The cluster analysis showed that 10 populations S. Baicalensis were classified into 2 groups, but it was not associated with geographical distribution.