[Objective] Discussion on academic ideas and clinical experience of Professor Fu Ping in treatment of polycystic ovary syndrome. [Methods] From the etiology and pathogenesis, therapeutic principle and therapy to expound the academic viewpoints and clinical experience of Professor Fu Ping in treatment of polycystic ovary syndrome, the prescription and Chinese medicine conditioning characteristics are summarized, and exemplify that. [Results] Professor Fu Ping believes that the pathogenesis of this disease is a virtual reality, such as phlegm and blood stasis;according to the etiology and pathogene-sis, strengthening the body resistance to eliminate pathogenic factors, coordinating Chong and Conception Vessels is the main rule; dissipating phlegm and removing dampness, warming the kidney and strengthening the spleen, nourishing liver kidney, regulating qi and activating blood is the clinical common therapy, clinical y obtaining better therapeutic effect. [Conclusion] The clinical experience of Professor Fu Ping in treatment of polycystic ovary syndrome is effective, has the value of popularization and application.

OBJECTIVETo observe the effect of Pi transportation, dampness resolving and phlegm expelling herbs (PTDRPEH) on the obesity degree, fat hormones, and leptin resistance in diet-induced obesity (DIO) rats.

METHODSAmong the 120 Wister rats, 10 were recruited as the blank control group (fed with basal forage), and the remaining 110 were administered with high-fat high-nutrition forage for 17 weeks. According to weight, we obtained 40 DIO rats and 10 diet-induced obesity resistance (DIO-R) rats. DIO rats were further divided into four groups, i.e., the DIO model group (normal saline, at the daily dose of 2 mL), the sibutramine group (at the daily dose of 1.6 mg/kg), the dampness resolving and phlegm expelling group (DRPE, at the daily dose of 3.2 g/kg), and the Pi transportation group (PT, at the daily dose of 3.2 g/kg). All were given by gastrogavage. Normal saline (2 mL) was given by gastrogavage to rats in the blank control group and the DIO-R group. The basal forage was administered to rats in the blank control group, while high fat forage was continually given to rats in the remaining five groups. Their body weights and body lengths were measured after 16 weeks of gastrogavage. All intra-abdominal fat was taken out to measure the degree of obesity and fat contents. Insulin resistance index (IRI), blood glucose, triglycerides, cholesterol, leptin, neuropeptide Y (NPY), tumor necrosis factor alpha (TNF-alpha), and adiponectin were detected after blood withdrawing. Leptin, TNF-alpha, adiponectin, suppressors of cytokine signaling-3 (SOCS-3), and other relevant adipose hormones and inflammatory cytokines were examined in the fat homogenate.

RESULTSCompared with the blank control group, DIO model rats' body weight, body mass index (BMI), fat factor, IRI, serum leptin, TNF-alpha, and SOCS-3 significantly increased (P < 0.05, P < 0.01); serum NPY, serum leptin, and adiponectin decreased (P < 0.05). Leptin increased and NPY decreased in DIO-R model rats. Compared with the DIO group, DIO-R model rats' body weight, BMI, fat factor, IRI, serum NPY, TNF-alpha, and SOCS-3 all decreased (P < 0.05, P < 0.01); leptin and adiponectin in serum and the fat homogenate all increased (P < 0.05, P < 0.01). After intervention with Sibutramine, rats' body weight, BMI, fat factor, and TNF-alpha in the fat homogenate obviously decreased (P < 0.05, P < 0.01). Serum TNF-alpha decreased, leptin and adiponectin increased in rats of the DRPE group (P < 0.05, P < 0.01). BMI, fat factor, IRI, leptin, and SOCS-3 showed a decreasing tendency, but with no statistical difference (P > 0.05). The body weight, BMI, fat factor, IRI, TNF-alpha, and SOCS-3 all decreased in the PT group (P < 0.05, P < 0.01); leptin and adiponectin in the serum and the fat homogenate increased (P < 0.05, P < 0.01).

CONCLUSIONSSibutramine could reduce body weight and TNF-alpha in the adipose tissue. Herbs of PT could inhibit fat diet-induced obesity and insulin resistance (IR), with superior effect to herbs of DRPE. Its mechanism might be closely related to promoting leptin and adiponectin secreted by fat, reducing leptin resistance, and elevating serum levels of leptin and adiponectin.

Adiponectin ; blood ; Animals ; Diet, High-Fat ; Disease Models, Animal ; Drugs, Chinese Herbal ; pharmacology ; Insulin Resistance ; Leptin ; blood ; Male ; Obesity ; blood ; drug therapy ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha ; metabolism

Acquired Immunodeficiency Syndrome ; prevention & control ; Humans

Acquired Immunodeficiency Syndrome ; prevention & control ; China ; Humans

Anti-Arrhythmia Agents ; adverse effects ; therapeutic use ; Arrhythmias, Cardiac ; drug therapy ; Humans

Objective To evaluate the role of the fractional dilatation and curettage (D&C) in the diagnosis of atypical hyperplasia of endometrium. Methods The retrospective analysis was performed in 48 patients diagnosed as atypical hyperplasia of endometrium and treated in our hospital from Aug.2009 to Dec.2010. We compared the pathology results of D&C with hysterectomy specimens, and investigated the reasons for the difference. Results The six patients (12.5%) with mild atypical hyperplasia of endometrium still presented with significant pathological changes after D&C (χ2 = 5.90, P＜0.05), 11 cases (22.9%) in 14 patients(29.2%) with moderate atypical hyperplasia (χ2=0.49, P＞0.01), 18 cases (100%) in patents with serious atypical hyperplasia, among which even 8 patients (44.4%) were verified as endometrial cancer. Conclusions There exists pathological discrepancy between the fractional D&C and hysterectomy specimens. Patients with severer atypical hyperplasia may have a higher risk of developing endometrial cancer.

Objective To observe the effects of aspirin on PCNA and cyclin D1 expressions in diethylnitrosamine (DEN) induced hepatic cancer of the rat. Methods Sprague-Dawley (SD) rats were randomly divided into DEN group and DEN plus aspirin group. Each group was further divided into 8,12,16 week subgroups. The expressions of PCNA and cyclin D1 in hepatic tissue were examined with inmunohistochemistry. Results In DEN plus aspirin group cirrhosis was less severe and carcinoma developed later than that in DEN group. Hepatic carcinoma occurred in four rats out of six in DEN group at the 16th week (P<0.05). In DEN plus aspirin group PCNA and cyclin D1 expressions were significantly lower than those in DEN group(P <0.05) , inhibiting effects on cyclin D1 expression was evidently great at 16th week (F=11.944,P<0.05) and inhibiting effect on PCNA was obvious from 12th to 16th week (F=5.696 and F=11.057, P<0.05 ). Conclusion Aspirin downregulates the expressions of PCNA and cyclin D1 in hepatic tissues and inhibits the genesis and development of DEN induced hepatic cancer of the rats.

With the advance of modern neonatal management, the increase of survival of infants born with ELBW has resulted in collateral increase in incidence of infants with serious chronic lung disease, typically brnchopulmonary dysplasia (BPD). Long-term sensory, motor and cognitive impairments are common outcomes in survivals with moderate and severe BPD and may persist during school years and adolescence. Increasing evidence suggest that BPD exerts a significant effect on brain growth and development and may be associated with chronic sublethal hypoxia which compond the risk of extended brain injury and NS complications such as cerebral palsy. Animal studies have demonstrated progressive gliosis and cerebral ventriculomegaly, injured subcortical white matter and corpus callosum, dysynchrony synaptic development and disrupted neurotransmitssion in the hypoxia newborn brain. In this literature we built upon the review of neurogical and congnitive outcome in preterm infants with BPD and structural, functional and neurochemical alterations in ainimals following clinical and experimental hypoxia respectively, which may underlie the primary or potential mle for chronic sublethal hypoxia on premature brain development.

Patients with advanced gastric cancer lose the surgical indications.Chemotherapy can improve the overall survival and quality of life,which is the main treatment option.But there is no standard chemotherapy regimen for the patients with advanced gastric cancer.Since its initial approval,S-1 is widely used in gastric cancer.Several studies were performed to explore combinations of S-1 with other cytotoxic drugs such as platinum,docetaxel,paclitaxel,and irinotecan.All these combinations were found to be promising,with response rates of around 40％-50％ and relatively favorable safety profiles.

Objective To observe the effects of hemodialysis on nutritional status and water balance in newly diagnosed end-stage renal disease(ESRD)patients.Methods Thirty newly diagnosed ESRD patients who accepted hemodialysis for the first time were included in the study;body water balance was analyzed by bioelectric impedance analysis(BIA)method and nutritional status were evaluated by BIA,anthropometry and blood biochemical indicators.Results Total body water,extracellular fluid,intracellular fluid,normalized total body water,normalized extracellular fluid,normalized intracellular fluid were decreased significantly after 3 months of hemodialysis(P