Melatonin has a significant inhibitory effect on various cancers,especially on breast cancer.In estrogen receptor (ER)-positive human breast cancer,anti-cancer effects ofmelatonin on breast cancer cells and transplanted tumors mainly achieve by suppressing ER mRNA expression and ER transcriptional activity via the MT1 receptor.In addition,melatonin regulates the transactivation of other members of the nuclear receptor super-family,estrogen metabolizing enzymes,and the expression of related genes.Furthermore,melatonin also suppresses tumor aerobic metabolism,critical cell-signaling pathways relevant to cell proliferation,survival,metastasis,and drug resistance.Melatonin demonstrates both cytostatic and cytotoxic activity in breast cancer cells that appears to be cell-type specific.Studies on animal and human models indicate that disruption of the circadian nocturnal melatonin signal promotes the growth,metabolism,and signaling of human breast cancer,resulting in invalid hormone therapy and chemotherapeutic resistance in breast tumors.

Gadolinium ethoxybenzyl dimeglumine (Gd-EOB-DTPA),a newly applicable hepatocyte-specific contrast agent,can provide both dynamic and hepatobiliary images and has been rapidly accepted by clinicians for the diagnosis of liver lesions and preoperative evaluation.Gd-EOB-DTPA can fulfill hepatic perfusion imaging,detection and characterization of focal liver lesions,evaluation of liver function,and predict biological behaviors of hepatocellular carcinoma (HCC) within the same examination in a relatively short time window.A large number of domestic and foreign studies have confirmed that hepatobiliaryspecific enhanced magnetic resonance imaging (MRI) was significantly superior to MRI scan,enhanced CT and ultrasound in diagnosing HCC.With the help of the advanced imaging techniques,surgeons can accurately diagnose and assess the situation of patients to implement individualized treatment plans,and therefore these will promote the development of precision hepatic surgery.

Maspin,one kind of tumor suppressor gene,belongs to the serine proteinase inhibitor (serpin) ultra family's member.Recent studies found that it suppresses the tumor occurrence and development and has the inhibition of tumor metastasis through suppressing the tumor angiogenesis and increasing the cell adhesion,which may be a new way for gene therapy.

In 1982, ADP-ribosylation factors (ARFs), a family of GTP-binding proteins associated with Golgi complexes, were initially recognized based on their ability to stimulate the ADP-ribosyltransferase activity of cholera toxin in vitro, and named so. In fact, this pathophysiologic activity has been useful for functionally defining members of the ARF family. However, during last decade, genetic and biochemical studies have shown the physiologic role of ARFs that also play an essential role in intracellular vesicular transport, particularly in Golgi complexes, activate phospholipase D activity as a nod of signal transduction of cells. Moreover, their more functions were revealed continuously recently. Especially, human ARF1 was found earliest, and studied profoundly in human body cell. Therefore, in this article, there is a comprehensive review about its regulators and effectors, functions and its possibilities involved in tumorigenesis, development of tumors.

Mobile network is used to transmit signals for telemedicine dynamic ECG monitoring system.In this way,ECG monitoring can be performed to patients at all times and places,thus really realizing telemedicine dynamic ECG monitoring.In the paper,the system is studied.The discussion on how to transmit ECG signals and feedback the diagnostic message through mobile network is presented in detail.

Objective:To evaluate the effect of Ginseng-Sini in early goal directed treatment septic shock under PICCO.Methods: Forty four patents with septic shock were randomly divided into control group, which treated with Ginseng-Sini on the basis of routine treatment under PICCO, observation groups, which treated with only the basis of routine treatment under PICCO. Before and after the drugs were given for 6 hours, HR, IMAP, CVP, SpO2, Lac, CI, ITBVI, SVRI were monitored.Results: Before treatment, HR, IMAP, CVP, SpO2, Lac, CI, ITBVI, SVRI of the observation group were not different from the control group(P>0.05); after 6 hours of treatment, CI of the observation group were higher than that of the control group(P<0.05).Conclusion: Ginseng-Sini in the early goal directed of septic shock is effective, especially in improving tissue perfusion.

Objective To introduce the clinical application of Tono-Pen tonometer.Methods The intraocular pressure was detected with Tono-Pen XL tonometer at different time points for sixteen patients went through laparoscopic gynecologic operation,then the statistical analysis of the results was performed.Results In processes of artificial pneumoperitoneum and low position,the intraocular pressure escalated gradually,and after artificial pneumoperitoneum,the intraocular pressure descended rapidly.Conclusion Tono-Pen tonometer is the only tonometer can be used for the patient of general anesthesia until now.

Epilepsy is a common chronic disease of the nervous system in children.Antiepileptic drugs are the first choice for the treatment of epilepsy.However,about 20％-40％ of children with epilepsy will develop intractable epilepsy,which can affect children's mental development and bring heavy burden to families and the society.In addition to antiepileptic drugs,epilepsy surgery,neuromodulation and ketogenic diet can also be used as alternative treatments of intractable epilepsy.In order to give a reasonable advice,neurologists must be familiar with the indications and the advantages and disadvantages of the antiepileptic drugs and the various alternative treatments mentioned above.Only in this way can we reduce seizure frequency,even achieve the goal of curing epilepsy.

Deep vein thrombosis(DVT) refers to a blood clot that forms in a deep vein, and usually occurs in the lower extremities.Typical symptoms include swelling, pain or tenderness in the leg.DVT is one of the common complications of orthopedic surgery and has a complicated pathogenesis.The embolus can fall off into the lung, resulting in the death.MicroRNA (miRNA) is a class of endogenous and non-coding single stranded RNA consisting of 21~23 nucleotides, widely involved in a variety of biological processes.Recent studies have found that microRNA (miRNA) plays a significant role in the pathogenesis of DVT.This article reviews recent advances in the study of miRNAs as novel regulators, diagnostic tools and a therapeutic choice in DVT to provide new insights of its pathogenesis and therapeutic target.

OBJECTIVE:To investigate the key point of pharmaceutical care supplied by traditional Chinese medicine(TCM) pharmacist in current period.METHODS:Questionnaire survey was applied to analyze blind spot and common concern on TCM statistically,taking outpatients of our hospital as example.RESULTS:Specific content of pharmaceutical care of TCM was put forward.CONCLUSION:Hospital pharmacy supplies timely and specific pharmaceutical care of TCM to improve the diagnosis and treatment of TCM.Pharmaceutical care of TCM are required with the development of TCM.