1.Clinical investigation on the immune state of patients with hepatic cirrhosis and primary hepatic carcinoma
Chinese Journal of Primary Medicine and Pharmacy 2006;0(12):-
Objective To study the immune state and correlated strategy of patients with hepatic cirrhosis and primary hepatic carcinoma.Methods 17 patients with hepatic cirrhosis and 8 patients with primary hepatic carcinoma(PHC) in our hospital were collected since 2002.The indexcs of immune function were detected in all patients and some were re-examined.Results It was found that although the immune index varied in patients suffering from severe liver diseases,some regularities were shown as follows:(1)CD4 and CD4/CD8 in T lymphocyte subset declined markedly(P
2.Comparison of Recombinant Human ?-NGF from E.coli and CHO in Biochemical Characters
Jing JIANG ; Gui-Xiang JIANG ;
China Biotechnology 2006;0(02):-
Though prokaryotic cells could hardly express recombinant human beta nerve growth factor (rhNGF-?) with a proper three-dimensional conformation, using of E. coli as a host for industrial production of rhNGF-? is controversial. Recombinant human beta NGF was expressed in E. coli and was refolded in vitro. The isolated products was shown to be consistent with those expressed and secreted by CHO cells in biochemical characters by SDS-PAGE, RP-HPLC, mass spectrometry, N terminal analysis and bioassay determined using DRG and PC12 cells. The products can be acquired with 95% purity, 1.8 ng/U biological activity from both expression system,which remain invariable biological activity when lyophilized in excipient and store at 37℃?2℃, RH 75%?5% for 3 months. Moreover, the product refolded from inclusion bodies of E. coli shows the predominance in homogeneity and the lower cost.
3. Perioperative anesthesia management of crush syndrome caused by earthquake under field condition
Academic Journal of Second Military Medical University 2010;29(6):586-587
Objective: To summarize our experience on perioperative anesthesia management of patients with crush syndrome caused by earthquake under field condition. Methods: The clinical anesthesia data of 10 patients with crush syndrome caused by China Wenchuan earthquake, who were treated under field condition, were retrospectively analyzed, and our experience on perioperative anesthesia management was summarized. Results: After volume therapy, urine alkalization, and stabilization of internal environment, the 10 patients underwent debridement, decompression by fasciotomy or amputation under epidural anesthesia or brachial plexus block plus psychological therapy and moderate tranquillizer. During the operation, the patients showed smooth respiratory and cardiovascular characteristics without pain. Conclusion: Under field condition, regional anesthesia can provide adequate analgesic effect during and after the surgery. Early fluid resuscitation and life support are vital to the safety and life of patients.
5.Case of resting plaque psoriasis.
Chinese Acupuncture & Moxibustion 2014;34(8):768-768
6.Basic Research Progress on Electro-Acupuncture Treatment of Alzheimer's Disease
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(2):405-410
Alzheimer's disease (AD) is the most common form of dementia, which affects more than 35 million people worldwide with increasing tendency. AD brings stupendous economic burden for both the society and family. It has become a major global public health issue. Electro-acupuncture (EA) therapy has been widely used in AD treatment with satisfactory results. Based on the basic research, this paper explored the therapeutic effect of EA in AD treatment from the learning ability and morphological changes in AD animal models. From the cholinergic neuronal apoptosis theory, inflammatory response theory, oxidative stress theory and other aspects, the action mechanism of EA in the treatment of AD animal models were reviewed. At last, limitations of EA in AD treatment were analyzed. It proposed the outlook of a new type of EA-music EA in AD treatment. It provided a new idea and method for AD clinical treatment.
7.Thinking of Medical Students′Ecological Moral Cultivation under the View of Beautiful China
Chinese Medical Ethics 2016;29(2):187-189
Firstly, this paper analyzed the significance of strengthening medical students’ ecological moral ed-ucation under the view of Beautiful China. Secondly, it discussed the present situation of ecological moral and the reasons of lacking of ecological moral in medical students. At last, the authors pointed out the countermeasures to strengthen the moral cultivation of medical students’ ecological countermeasures under the view of Beautiful China. Therefore, we must strengthen the top-level design to ensure the ecological moral education enter into the national education system, enhance to maintain power to build the full-area coverage ecological moral teaching system, and strengthen institutional construction to establish long-term mechanism of ecologic moral education.
8.Advances in Study on Toll-like Receptors and its Gene Polymorphisms in Gastric Mucosal Diseases
Chinese Journal of Gastroenterology 2015;(7):431-434
The development and progress of gastric mucosal diseases is a complex process associated with multiple factors and underlying mechanisms,and individuals may present different genetic susceptibilities to gastric mucosal diseases. Various studies have demonstrated a strong link between Toll-like receptors( TLRs),as pattern recognition receptors,and the development and progress of gastric mucosal diseases. The gene polymorphisms of TLRs may change its encoded proteins or related signaling pathways,which results in different susceptibilities to gastric mucosal diseases;this might affect the development,progress and clinical outcome of the disease. In this review article,the advances in study on TLRs and its gene polymorphisms in gastric mucosal diseases were summarized.
9.Suppressing Function of Breast Cancer Metastasis Suppressor 1 in Breast Cancer Metastasis
Chinese Journal of Bases and Clinics in General Surgery 2003;0(03):-
Objective To review the recent studies on the suppressing function of breast cancer metastasis suppressor 1 (BRMS1) in breast cancer metastasis. Methods The recent literatures on the mechanisms of BRMS1 in the breast cancer that were published in and abroad were reviewed and summarized. Results BRMS1, similar to the other anti-metastasis genes, only suppresses the metastasis of breast cancer cells but has nothing to do with the growth of tumor. BRMS1 could suppress metastasis of tumor cells by reestablishing both the homospecific and the heterospecific gap junctional intercellular comminications (GJIC) and by altering the expressions of relevant metastasis genes in the breast cancer. Conclusion Further studies on BRMS1 may be helpful to understand the metastasis of breast cancer, which may provide a new way for the diagnosis and treatment of breast cancer.
10.The manifestation of children with dental disease and the relevant therapeutic ways
Journal of Practical Stomatology 2001;0(03):-
Objective: To inquire into the discrepancy in the behavior and therapeutic ways for the children at different age with dental diseases.Methods: 994 children at the age of 1~12 with dental diseases were divided into 3 groups on the base of their ages. Relevant therapeutic ways were taken according to their behavior. The influencing factors that made dental treatment finished smoothly were reached through analyzing the relationship among the children, the parents and the medical personals. Results: The manifestations of children's behavior had significant age differences when they received dental treatment. Non cooperative children constituted the majority of the infantile children, while the school age children were mostly cooperative. The ways chosen to treat children's dental diseases also had significant age differences. Compulsory means was the main way to treat infantile children and routine means to the pre school age and school age children. Inductive and threatening ways were always used for the non cooperative pre school age children. The non cooperative school age children were always received inductive means and seldom threatening and compulsory ones. The parents often accompanied with the infantile children, but did not with the pre school age and school age children. Conclusion: The age is a key factor to determine the clinical manifestations and the methods used to treat children's dental diseases.