Objective To evaluate the effect and the radiation reaction of esophageal cancer patients treated by LCHR.Methods 96 patients of esophageal cancer were treated by LCHR. 76 patients had pathology evidence. There were 65 males and 31 females. The ages ranged from 41 to 70 years with median 57.5 years. The patients with lesion in upper thoracic segment 21 cases, Middle thoracic segment 63 cases, lower thoracic segment 12 cases. The length of lesions: 7.0?cm 10 cases. They were randomly divided into two groups, The conventional radiation group (48 cases). And late course hyperfractionation (48 cases).Both groups were treated by 60Co ?- ray external radiation 2.0?Gy every time each day, five times in each week in conventional group, the total dose 64?Gy/32 fractions/44d; in the late course hyperfractionation group. 40?Gy in four weeks at first and then two times each day with 1.15～1.25?Gy every time and with 6～8 hours, interval, from the fifth week, ten times in each week, ale total dose 68～70?Gy/44～45d. Results All patients were followed at more then five years. The follow-up rate was 96.9%. The survival rate of 1,3,5-year in late course hyperactionation group were 81.1%, 44.1%, 26.8% and 61.7%, 25.1%, 16.9% in conventional group respectively. The survival rate of late course hyperactionation group is better than conventional group. Between the two groups , there was significant difference in the survival rate of 1,3-year (P0.05). Conclusions The result showed that the 1,3,5-year survival rate of LCHR of esophageal cancer is better than conventional radiotherapy. Between the two groups , there was significant difference in the survival rate of 1,3-year ,However there is no significant difference in the survival rate of 5-year. It is well tolerated, without late reactions in long term survivors.

Objective:To explor the effect of gp120mAb on synaptic transmission and plasticity changed by gp120 in the CA 1 region of rat hippocampal slices.Methods:We recorded the excitatory postsynaptic potentials (EPSP) and investigated effect of gp120mAb on long-term potentiation inhibited by gp120 in rat hippocampus in vitro.Results:The results showed that HIV-1 gp120 can inhibit the LTP induced by high-frequence stimulation schaffer in CA 1,gp120 had no effect on basal synaptic transmission.HIV-1 gp120(200 pmol/L) can inhibit the LTP maintance,gp120mAb of gp120-specific antibodies can reverse the inhibition effect,But IgG can't reverse it.Conclusion:The reverse effect of gp120-specific antibody gp120mAb on long-term potentiation inhibited by HIV-1 gp120 may contribute to the HAD pathogenesis.

The incidence rate of hepatocellular carcinoma (HCC) is increasing around the world and tends to decrease in East Asia and several regions in China;however, China still has higher incidence rate and mortality rate of HCC than most countries.Studies have shown that long-term antiviral therapy can inhibit HBV replication to a very low level or help patients with HCV infection achieve sustained virologic response, which can further reduce the incidence rate of virus-related HCC.New evidence suggests that compared with nucleos(t)ide analogues, PEG-IFNα has a better effect of secondary prevention.Studies also indicate that interferons play an important role in tertiary prevention of virus-related HCC.This article reviews the epidemiological studies on virus-related HCC in recent years and the role of antiviral therapy in second and tertiary prevention and points out that adequate and effective antiviral therapy is the basis for preventing the development and recurrence of HCC.

BACKGROUND:With the development of tissue engineering technology and the deep research of tendon regeneration, many problems caused by traditional tendon transplantation wil be solved. OBJECTIVE:To evaluate and prospect the effects of corresponding mechanical systems on seeding cel s based on the characters of tendon, stem cel s as wel as mechanical systems. METHODS:CBM, CNKI, CqVip and PubMed databases were retrieved for reviews and articles related to tissue-engineered tendon published from January in 2005 to December in 2015. The keywords were“tissue engineering, tendon, tendon stem cel , mechanical stimulation and seeding cel s”in Chinese and English, respectively. Final y a total of 63 articles were selected for overview. RESULTS AND CONCLUSION:As al kinds of stem cel s and the corresponding mechanical systems exhibit advantages and disadvantages when applied for tissue engineering, it is advisable to make appropriate choices according to the research needs. Tendon stem cel s show a broad application prospect in tendon regeneration, which wil grow into required tendon tissues through appropriate, accurate and gentle mechanical stimulations, thereby providing another alternative to improve the tendon healing.

Objective To study the safety and effect of ultrasound guided minimally invasive rotary cutting for treatment of benign breast lesions. Methods A single-center, prospective, randomized, controlled study method was used, 84 patients with breast benign lesions were randomly divided into observation group and control group, 42 patients in each group. Patients in the observation group were treated with ultrasound guided minimally invasive rotary cutting, patients in control group were treated with traditional surgery. The intraoperative and postoperative related indicators were compared between two groups. Results The intraoperative blood loss, length of incision, operation time in breast benign unilateral single and unilateral and bilateral lesions in the observation group were significantly less than those in the control group, with statistically significant difference (P<0.01) . The healing time, postoperative pain score, complications in breast benign unilateral single and unilateral and bilateral lesions in observation group were less than those in the control group, with statistically significant difference (P<0.01) . And the postoperative satisfaction, and the excellent rate of beauty in breast benign unilateral single、unilateral and bilateral lesions were better than control group, with statistically significant difference (P<0.01) . There was no breast deformation in observation group after treatment, and there were 3 patients of breast deformation in the control group has 3 patients, accounting for 7.14%. Conclusion Ultrasound guided minimally invasive rotary cutting is significantly superior to the traditional treatment in security and effectiveness for treatment of breast benign lesions in one single and unilateral multiple and bilateral lesions.

Objective To explore the changes of renal histology of neonatal rats with prolonged hyperoxic lung injury.Methods One-day-old rats were continuously exposed to oxygen ( 80％ ± 5％,n =60 ) or room air( 21％,n =60) after birth.HE stained renal samples were scored to evaluate the changes of histology on day 1,3,7,14,21 in the hyperoxia and control group.Results Compared with control group,hyperoxic group showed mild renal damage.Renal tubular hydropic degeneration,edema,dilation could be seen on day3,7.Renal tubular interstitial vessel dilation,congestion,and rare tubular hemorrhage,necrosis,regeneration could be seen on 14,21days.Fibrosis was not founded.There was no significant difference of histologic scores within 3 days (P ＞0.05 ),but after 7 days the difference of two groups were singnificant between the control and hyperoxia groups(P ＜0.05).Conclusions Hyperoxia exposure can lead to mild renal histology damage in neonatal rats with hyperoxic lung injury.

Objective To study changes in renal histology of neonatal rats with prolonged hyperoxic lung injury and monitored the expression of IFN-γ in kidney.Methods Full-time newborn rats were continuously exposed to oxygen(80％ ±5％ 02,n =100) or room air(21％ O2,n =100) after birth.Dynamic changes of renal histology and the expression of interferon (IFN)-γin kidney by immunohistochemical method were monitored on day 1,3,7,14,21 in the hyperoxia and control group.Results Normobaric hyperoxia indnced mild renal damage including renal tubular hydropic degeneration,edema,dilation,tubular interstitial vessel dilation,congestion,and rare tubular hemorrhage,necrosis,regeneration.Fibrosis were not seen.On day 3,7,14,the intensity of IFN-γexpression increased compared with the control group (P ＜ 0.05) and significantly increased on day 7 (P ＜ 0.01).IFN-γwere mainly expressed in tubular epithelia cells.On day 21,the intensity of IFN-γ expression decreased,and there was little difference compared with the control group.Condusions Renal damage can be induced by prolonged hyperoxia exposure.The intensity of IFN-γexpression increased in kidney,which contributed to the damage of kidney.

Objective To investigate the clinical significance of serum ferritin (SF) in child with Still's disease (SD).Methods This study included 28 children with SD who were treated at the Pediatric Department in the First Hospital of China Medical University from 2001 to 2007.Their clinical features,biochemical parameters,and the results of serum ferritin were noted.Results In SD group,there were 28 cases with fever (100%),14 cases with rash (50%),18 cases with arthritis/arthralgia(64%),24 cases with leukocytosis (86%),27 cases with SF and ESR elevation (96%).The average SF in SD group [(8182±3156)μg/L] was significantly higher than that in the control group [(244±210)μg/L](P<0.01).Conclusion Fever,rash,arthritis/arthralgia,and leukocytosis are main clinical characteristics of child SD.Inereasing serum level of ferritin will probably indicate the activity period of SD.

Objectives To evaluate the inhibitory effect of low dose glucocorticoid on progression of radiological damage in rheumatoid arthritis by systematic review.MethodsA search of MEDLINE (from 1966 to April 2010),Embase(from 1966 to April 2010),Cochrane Library(2 Issue,2010),CBM disc,CNKI,WANFANG and VIP Database was undertaken to collect randomized controlled trials published before April 2010 based on the Cochrane Collaboration recommendations.Additional reports were identified from the reference lists.Statistical analysis was performed with RevMan 5.0 software.ResultsEleven studies that met the inclusion criteria,in which 1395 patients,were included.Meta-analysis showed that the standardised mean difference in progression was 0.40 (95％CI 0.27～0.54 ) in favour of glucocorticoids over the first year.In studies that lasted for 2 years,the standardised mean difference in progression in favour of glucocorticoids at 1 year was -0.39[95％CI(-0.50～-0.27)] and was -0.73[95％CI(-1.29～-0.16)] at 2 years.All studies except one showed benefit of glucocorticoids treatment.ConclusionsThe results of this study has shown that low dose glucocorticoids can substantially reduce the progression rate of erosion in rheumatoid arthritis.

Objective To investigate the clinical implication value of using Doppler ultrasound to detect renal hemodynamic changes in children with Henoch-Schonlein purpura.Methods Color Doppler ultrasound was used to detect renal hemodynamic changes of main renal arteries and intedobar renal arteries and arcs renal arteries in 40 cases of Henoch-Schonlein purpura,whose urine routine,microalbuminuria were also tested,and 32 healthy children served as control group.Results Maximum crest flow rate (Vmax) during systole,minimum crest flow rate(Vmin) during diastole and resistance index(RI) of main renal arteries and interlobar renal arteries of children in HSP group were all higher than those of control group,while Vmax,Vmin and RI of arcs renal arteries were almost the same.Color doppler ullrasound showed that 28 cases were abnormal in renal flow,which accounted for 70％.Fourteen cases with abnormality were detected in routine urine and 18 cases in microalbuminutia,which accounted for 35％ and 45％ of total cases respectively.Sensitivity of color doppler ultrasound was higher than microalbuminuria and routine urine,while the sensitivity difference was not statistically different between microall uminuria and routine urine.Conclusions Renal hemodynamics is a sensitive index to find out renal lesion of early stages in children with Henoch-Schonlein purpura.