Objective To study the changes of blood coagulation function in early stage of acute renal failure patients, and illustrate its significance. Methods From October 2011 through January 2013, 80 patients with acute renal failure in the Nephrology Department and Pediatrics Department of Yuebei People’s Hospital were enrolled in this study,50 health people in the same period as control group,then compare the differences in creatinine, blood urea nitrogen, blood platelet(PLT), activated partial thromboplastin time(APTT), prothrombin time(PT), thrombin time(TT), plas-ma fibrinogen (FIB) between the two groups. Results The FIB levels and PLT count in observation group were higher than those of controls group (P<0.05), but APTT,PT,TT showed no statistically significant difference (P>0.05). Con-clusion Hypercoagulabale state could occur in patients with acute renal failure in early stage, abnormal clotting may be participates in occurrence of acute renal failure.

Loganin(LOG),a bioactive compound derived from Cornus officinalis Siebold & Zucc,has been understudied in the context of osteoarthritis(OA)treatment.In this study,we induced an inflammatory response in chondrocytes using lipopolysaccharide(LPS)and subsequently treated these cells with LOG.We employed fluorescence analysis to quantify reactive oxygen species(ROS)levels and measured the expression of NLRP3 and nuclear factor erythropoietin-2-related factor 2(NRF2)using real-time quantitative polymerase chain reaction(qRT-PCR),Western blotting,and immunofluorescence(IF)techniques.Additionally,we developed an OA mouse model by performing medial meniscus destabilization(DMM)surgery and monitored disease progression through micro-com-puted tomography(micro-CT),hematoxylin and eosin(H&E)staining,safranin O and fast green(S&F)staining,and immunohisto-chemical(IHC)analysis.Our results indicate that LOG significantly reduced LPS-induced ROS levels in chondrocytes,inhibited the activation of the NLRP3 inflammasome,and enhanced NRF2/heme oxygenase 1(HO-1)signaling.In vivo,LOG treatment mitigated cartilage degradation and osteophyte formation triggered by DMM surgery,decreased NLRP3 expression,and increased NRF2 expres-sion.These findings suggest that LOG has a protective effect against OA,potentially delaying disease progression by inhibiting the ROS-NLRP3-IL-1β axis and activating the NRF2/HO-1 pathway.