0.05).But in the reported 6 groups patients,the fatality rate in 5 groups was higher that in the 16 patients,and the difference(P

Gene chips have been widely applied for the study of lymphoma,involvement discovering tumor-associated genes,assisting classification and investigating cell origin.So far,studies about gene chips detection mainly focus on B-cell lymphomas and T-cell lymphomas.According to those studies,traditional classifications of some kinds of lymphomas have been suspected and cell origin of some kinds of lymphomas have been suggested,which lay the foundation for further study.However,there are still somethings unknown about extranodal NK/T-cell lymphoma,more gene chip detection should be performed for further understanding of the tumor.

Objective To investigate the therapeutic effect of spleen-strengthening,lung-clearing and phlegm-resolving herbs for the treatment of acute attack of chronic obstrustive pulmonary disease(COPD) complicated with systemic inflammatory response syndrome(SIRS),and to observe their effect on nuclear factor ?B(NF-?B)expression level.Methods Sixty qualified patients differentiated as deficiency of spleen and lung,phlegm-heat accumulating the lung were equally randomized into two groups:the control group received routine western medical treatment including oxygen inhalation,antibiotics and bronchodilator,and the treatment group received Chen Xia Liujunzi Decoction and Weijing Decoction,which have the actions of strengthening spleen,clearing lung,and resolving phlegm,one dose per day,for 7 days.The changes of clinical symptoms and signs,blood gas parameters and NF-?B expression level were observed.Results After treatment,clinical symptoms and signs such as cough,expectoration,dyspnea,shortness of breath,and wheeze were relieved in both groups(P

[Objective] To observe the influence of Modified Qianjin Weijing Decoction (MQWD) on airway clearance in patients with acutely exacerbated chronic obstructive pulmonary disease (AECOPD) , which was differentiated as the syndrome of phlegm-heat congesting lung. [Methods] A prospective control trial was carried out in 60 AECOPD patients with phlegm-heat congesting lung. The patients were equally randomized into two groups: the treatment group (group A) was treated with MQWD and routine western medicine, and the control group (group B) with routine western medicine only. The therapeutic effect, indexes of lung function including FEV1 (forced expiratory volume in one second), FVC (forced vital capacity), FEV1/FVC, Zrs (total respiratory impedance) and R5 (total airway resistance), and in particular, the airway clearance rate (Ct) were observed and compared in the two groups. [Results] In the treatment group, the markedly effective rate was 70.00 % , higher than that (23.33 % ) in the control group ( P 0.05) but Ct in 60-minute and 90-minute treatment was much improved in the treatment group than that in the control group (P

Objective To determine whether rapid and delayed tolerance to focal cerebral ischemia can be induced by pretreatment with single electroacupuncture (EA) at the Baihui acupoint in rats. Methods Forty-eight healthy male SD rats weighing 280-320 g were randomly divided into 6 equal groups with 8 animals in each group: (1) control group received no pretreatment before focal cerebral ischemia; (2) electroacupuncture group was further divided into 5 groups in which EA was performed at Baihui acupoint and electric stimulation was maintained for30min0.5 h(EAl),1 h(EA2),2 h(EA3),3 h(EA4) or 24 h(EA5) before focal cerebral ischemia. The animals were anesthetized with isoflurane and spontaneous respiration was maintained. Middle cerebral artery occlusion (MCAO) was performed using a nylon thread with a rounded tip inserted into internal carotid artery and thread cranially until resistance was felt. MCAO was maintained for 2 h, then the nylon thread was withdrawn to allow reperfusion . After MCAO the animals were observed for 24 h for neurological deficits which were assessed by a 0-5 grade scoring system (0 = no deficit, 5 = death) . The animals were then sacrificed and brain was immediately removed for estimation for the size of cerebral infarction. Results There were significantly less neurological deficits and the size of infarction was smaller in group EA3 and EA5 than those in control group. There were no significant differences in neurological deficits and size of infarction between group EA1,EA2,EA4 and control group. Conclusion Pretreatment with single electroacupuncture stimulation for 30 min at Baihui acupoint can induce rapid and delayed tolerance to focal cerebral ischemia. Rapid tolerance develops 2 h after pretreatment while delayed tolerance develops 24 h after pretreatment.

Objective To study the effect of interleukin 13(IL-13)on mucin gene Muc5ac and EGFR expression in mouse lungs. Methods Twenty-four male BALB/c mice were randomly divided into control group and different dose of IL-13 (50ng, 100ng and 250ng) groups, six mice per group. Muc5ac mRNA, and Muc5ac and EGFR protein expressions were detected by RT-PCR and immunohistochemical method, respectively. Results Both Muc5ac and EGFR positive products were located in the cytoplasm of airway epithelial cells. Compared with control group, IL-13 could increase Muc5ac mRNA, and Muc5ac and EGFR protein expressions in dose-dependent manner(all P

Ca~(2+)-activated chloride channels (CaCC, CLCA) are a new family of chloride channels discovered recently, which are related to Ca~(2+)-sensitive chloride ions transport, and there were several members identified currently in different biologic bodies. New studies have shown that its member gob-5 in murine (its human counterpart is CaCC1) plays a pivotal role in airway goblet cell metaplasia, mucus overproduction, MUC5AC gene expression as well as airway hyperresponsiveness (AHR) in asthma, and is a key molecule in the induction of murine asthma and an asthma-related gene. Inhibition of their function and/or their signaling pathway may therefore provide a new therapeutic strategy for asthma.

Objective To discuss the microsurgery approaches and the prevention and treatment of complication about the tumors in cerebellopontine angle.Methods The 53 cases with cerebellopontine angle brain tumor were retrospectively analyzed.Results In all 53 patients,the tumor of 23 cases were full-resected,29 cases' tumor were resected more then 3/4,only one cases' tumor was partly treated.Following operation,one case died,5 cases had hearing decreasing,3 cases had severely facial nerve weakness and non hearing,10 cases had facial nerve anaesthesia,futhermore there was one case with long-period coma because of the injury of brain stem.Conclusion The important factors that decrease the complications of cerebellopontine angle tumor surgery include surgery approachs,operating experience and mechanism of complication.

Objective After the rabbits were electrocuted by 220V AC,we found that the pathological changes in the surface of the bones electrocuted could be one objective and quantitative index for the diagnosis of electrocution in the forensic pathology.Methods The experiment animals were divided into four groups,including: the antemortem electrical injury,postmortem electrical injury,putrefied and the normal.After specimens from each group being taken X ray examination,all specimens were then observed the morphological appearance of the surface of the bones with scanning electron microscopy(SEM),meanwhile,detected the kinds and contents of element in the electrical injury area with energy spectrum.Results①small holes on the surface of electrified area and the detection of contents of the elements in the high-density surrounding the holes could be a index for the diagnosis of AC injury and able to differentiate of the antemortem electrical injury,the postmortem electrical injury and the putrefied bones.②the morphologic changes of small holes and the alteration of the contents of elements such as calcium,phosphorus and carbon could be helpful to estimate the time of electrical injury.Conclusion The morphological appearances and the changes of elements in the surface of the bones electrocuted could be a useful index to analyse the differences among the antemortem electrical injury,postmortem electrical injury,putrefied and the normal bones.

0.05).The expression began to increase around the infarction at 12h reperfusion,it reached the peak at the 3th day in the boundary zone and then it gradually decreased.Conclusion The overexpression of IL 6 played an important role in the course of cerebral ischemic reperfusion, and could damage the brain tissue.