1.Curative Effect Observation of Transfer Factor Oral Solutions as Adjunctive Therapy in Elderly Patients with Recurrent Respiratory Tract Infection (RRTI)
China Pharmacist 2014;(2):260-261
Objective:To observe the curative effect of transfer factor oral solutions as the adjunctive therapy in ederly patients with recurrent respiratory tract infection ( RRTI) . Methods:Totally 74 ederly patients with RRTI were selected and divided into the observation group and the control group randomly. The patients in the two groups were given anti-infection and symptomatic treatment during the acute stage of attack. The patients in the observation group were additionally given transfer factor oral solutions 10ml, po, tid for 3 months. The changes in serum immunoglobulin IgG, IgA and IgM levels in the two groups before and after the medical treat-ment were compared, and the clinical curative effect and adverse drug reactions ( ADR) were observed as well. Results: After the medical treatment, the serum IgG, IgA and IgM levels in the observation group were obviously increased than before (P<0.05), while those in the control group showed no obvious changes (P>0. 05). The total clinical efficiency in the observation group was much higher than that in the control group (P<0. 01). The ADR between the two groups with light symptoms showed no statistical differ-ences (P>0. 05). Conclusion:Transfer factor oral solutions as the adjunctive therapy in ederly patients with RRTI has the favorable clinical curative effect and safety, and the underlying mechanisms may be concerned with the effect of enhancing serum immunoglobulin IgG, IgA and IgM levels, as well as humoral immune function.
2.Effect of blood glucose control level on prognosis in cerebral infarction with stress hyperglycemia
Chinese Journal of Postgraduates of Medicine 2013;36(34):4-6
Objective To analyze the effect of blood glucose control level on prognosis in cerebral infarction with stress hyperglycemia.Methods Ninety-two cases of new cerebral infarction within 24 h with stress hyperglycemia were divided into control group (46 cases) and observation group (46 cases).The blood glucose was controlled in 4.0-6.0 mmol/L in control group and 6.1-8.3 mmol/L in observation group.The hypoglycemia rate,infection rate,fatality rate,NIHSS score and Barthel score was observed in two groups.Results In control group,there were 14 cases cured,19 cases significantly improved,12 cases improved and 1 case invalid,while in observation group,there were 11,17,15,3 cases respectively,and the difference was not statisticly significant (P > 0.05).The hypoglycemia rate,infection rate,fatality rate was 19.6%(9/46),10.9%(5/46) and 2.2%(1/46) respectively in control group,while in observation group was 4.3% (2/46),15.2% (7/46) and 4.3% (2/46) respectively.The hypoglycemia rate was different between two groups(P < 0.05),but the infection rate and fatality rate was not statistic difference between two groups(P >0.05).The NIHSS and Barthel score was not different between two groups before treatment (P > 0.05).In control group the NIHSS after 1 week and 30 days after treatment and Barthel score 30 days after treatment was (15.47 ± 7.78),(9.85 ± 6.47),(67.18 ± 20.24) scores respectively,in observed group was (16.01 ±7.49),(10.17 ±5.84),(65.82 ± 19.93) scores respectively,which was improved compared with that pretreatment,but there was no significant difference between two groups(P > 0.05).Conclusion The blood glucose controlled in 6.1-8.3 mmol/L does not increase the infection rate and fatality rate,but can reduce the hypoglycemia rate and promote neural function recovery in cerebral infarction with stress hyperglycemia.
3.Classification of Etiology Theory in TCM Based on Concept of Unification of Human and Nature
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(07):-
This article expounds the formation,connotation and development of the etiology theory in TCM.By analyzing the deficiency of the existent etiology theory in TCM,we proposed that the essence of the etiology theory in TCM should be studied based on the concept of unification of human and nature.With the guidance of the concept of unification of human and nature,the etiology theory in TCM could be formed an integrated theory.The classification of etiology in TCM which includes basic etiology,secondum etiology and developing etiology was proposed,which makes the etiology theory system in TCM more scientific and logical.
4.The effect of intensive insulin therapy on cerebral infarction combined with hyperglycemia:a report of 70 cases
Chinese Journal of Postgraduates of Medicine 2014;37(1):17-20
Objective To investigate the effect and prognosis of intensive insulin therapy on cerebral infarction combined with hyperglycemia.Methods Seventy cases of cerebral infarction combined with hyperglycemia were divided into two groups by random number table method.Thirty-five cases in control group,were treated with insulin,and the blood glucose was controlled < 11.1 mmol/L; 35 cases in intensive group,were treated by insulin pump,and the blood glucose was controlled in 4.4-8.3 mmol/L.The degree of neurological damage and improvement of daily life in two groups before and after treatment was compared by National Institutes of Health Stroke Scale(NIHSS) and modified Rankin Scale(mRS) scores.Insulin dosage,the time for reaching the standard,incidence of hypoglycemia,pulmonary infection rate and fatality rate was recorded in two groups.Results The NIHSS and mRS scores between two groups before treatment had no statistical significance (P > 0.05),and after 30 d treatment,the NIHSS and mRS scores in control group [(8.29 ±2.74),(2.96 ±0.74) scores] and intensive group [(6.83 ±3.16),(2.02 ±0.62) scores] were obviously improved compared with those before treatment,and the improvement in intensive group was better than that in control group (P< 0.05).In intensive group,the insulin dosage and the time for reaching the standard was less than that in control group [(36.40 ± 6.91) U/d vs.(51.70 ± 9.86) U/d,(4.30 ± 0.87)d vs.(6.60 ± 1.24) d],incidence of hypoglycemia and fatality rate was lower than that in control group[5.7% (2/35) vs.25.7% (9/35),0 vs.8.6% (3/35)],the difference was statisticly significant (P < 0.05),but the pulmonary infection rate between two groups had no statisticly difference (P > 0.05).Conclusion The curative effect of intensive insulin therapy on cerebral infarction combined with hyperglycemia is better,and is helpful to the neural functional recovery.
5.Therapeutic Evaluation of Traditional Chinese Medicine Combined with Western Medicine for Pulmonary Embolism:An Observation of 16 Cases
Journal of Guangzhou University of Traditional Chinese Medicine 2001;0(03):-
0.05).But in the reported 6 groups patients,the fatality rate in 5 groups was higher that in the 16 patients,and the difference(P
7.Comparison between CR and DR
Chinese Medical Equipment Journal 2003;0(10):-
Objectine To study the performance between CR and DR equipments. Methods To compare chest x-ray between the CR and DR equipment. Results The pathological detection with DR equipment is 20% higher than that with CR. Conclusion The quantity of information of DR is higher than CR.
8.Correlation of the quality of life and lower urinary tract symptoms in patients under intravesical chemotherapy
Chinese Journal of Urology 2014;35(9):664-667
Objective To evaluate the quality of life (QoL) in patients undergone intravesical chemotherapy for non-muscle invasive bladder cancer and analyze the correlation of the quality of life and low urinary tract symptoms in this group of patients.Methods 31 male patients and 15 female patients were enrolled from Jan.2012 to Mar.2013.The average age was 54 (35-71) years.Questionnaires of QoL and core lower urinary tract symptom score (CLSS) were given to 46 patients before intravesical chemotherapy and the 1 st,6th month after starting the instillation.Before the instillation,the scores of QoL and CLSS were 55.7±6.2 and 6.5±2.1,respectively,the change of QoL and CLSS were compared to baseline,and then the correlation of the low urinary tract symptoms and quality of life was analyzed.Results At the end of 1st and 6th month,the QoL scores were 74.7±8.1 and 78.5± 10.6.The CLSS scores were 8.9±2.0 and 9.1 ± 1.8,respectively.The differences were significant (P <0.05) when compared to the baselines.The areas of working activity and free time were affected much more than other areas,and the scores increased from 8.3±2.1 and 19.2±5.7 to 14.3±5.6 and 23.7±4.2,respectively.The area of free time was found to be associated with local symptoms (r=0.61).Conclusions Intravesical treatment can impair the QoL of patients.Low urinary tract symptom is an important factor and is associated with impairment of QoL,suggesting the relief of local symptoms may improve the overall quality of life.
9.Study of signaling pathway related tophosphatase of regenerating liver 3
Journal of Medical Postgraduates 2017;30(5):537-541
PRL-3, belonging to the family of protein tyrosine phosphatase, has been found to be high expressed in colorectal cancer, gastric cancer, ovarian cancer and melanoma.It also has been reported that PRL-3 plays an important role in the progression of tumor.With the distinction of PRL-3 in tumor progression, especially in the metastatic tumor, there are more and more researches about the regulating mechanism of PRL-3.This paper reviews the development of signaling pathway of PRL-3.
10.The gene expression profile in the pathological diagnosis and differential diagnosis of tumors
Practical Oncology Journal 2015;(3):275-278
Through analyzing the gene expression profile of tumor cells with gene chip technology and se -lecting the differentially expressed genes of different tumor individuals and tumor types ,researchers find that these genes are not only connected with tumor growth ,proliferation,apoptosis,and signal transduction,but also with tumor pathogenesis,tumor infiltration,tumor metastasis and tumor drug resistance .Some tumor differentially ex-pressed genes or genomes show that these genes are even associated with tumor histological source and histological type.It demonstrates practical application value in the pathological diagnosis and differential diagnosis of tumors .