1.Autoimmune diseases and fungal infections: immunological mechanisms and therapeutic approaches.
Chinese Medical Journal 2009;122(5):483-485
Candidiasis
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drug therapy
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immunology
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metabolism
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Diabetes Mellitus, Type 1
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complications
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drug therapy
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immunology
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therapy
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Humans
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Lupus Erythematosus, Systemic
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drug therapy
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immunology
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metabolism
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Mycoses
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complications
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immunology
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therapy
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Paraneoplastic Syndromes
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drug therapy
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immunology
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metabolism
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Pemphigus
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drug therapy
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immunology
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metabolism
2.Recent advance in peripheral T-cell lymphoma, not otherwise specified.
Chinese Journal of Pathology 2010;39(6):427-429
Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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CD3 Complex
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metabolism
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Chromosomes, Human, Pair 3
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Chromosomes, Human, Pair 5
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Cyclophosphamide
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therapeutic use
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Doxorubicin
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therapeutic use
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Gene Rearrangement, T-Lymphocyte
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Humans
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L-Lactate Dehydrogenase
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metabolism
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Lymphoma, T-Cell, Peripheral
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drug therapy
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genetics
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metabolism
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pathology
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Mutation
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Neoplasm Staging
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Prednisone
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therapeutic use
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Vincristine
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therapeutic use
5.Imaging comparison for avascular necrosis of the femoral head induced by different etiologies
Dezhou ZHANG ; Xuebing YI ; Jian ZHONG
Chinese Journal of Tissue Engineering Research 2013;(48):8455-8460
bone fracture, mild col apse of the articular surface;femoral head deformation, bone fracture, articular surface col apse, hip degeneration. MRI of four categories of avascular necroses appeared as phase Ⅰ:line-like low signal of weight-bearing area of femoral head on T1WI, high signal on T2WI as the main change. Phase Ⅱ:clear boundary crescent-shaped uneven signal on T1WI, T2WI displayed moderately higher, uneven slightly lower signal around, showing a typical two-line sign. Phase Ⅲ:femoral head deformation, subchondral fracture, col apse, crescent formation, zonal low signal on T1WI, medium or high signal on T2WI. Phase Ⅳ, Ⅴ:complete destruction of articular cartilage, joint space narrowing, significant col apse and deformation of the femoral head, non-specific secondary osteoarthritis of the acetabulum, such as sclerosis, cystic degeneration and marginal osteophyte. The X-ray, CT, MRI performances of four types of avascular necroses at the same period were basical y the same.
7.Prospective and comparative study of nucleoplasty and conservative treatment for cervical disc herniation
Jian LI ; Zhihong ZHONG ; Ping ZHANG
Orthopedic Journal of China 2006;0(15):-
0.05).The mean hospital stay of PCN group was significantly shorter than that of conservative treatment group(4.5 days and 16.5 days respectively(P
8.Protective effect of carnosine on cognitive impairment induced by subcortical ischemic vascular dementia
Jing MA ; Jian ZHANG ; Zhong CHEN
Chinese Pharmacological Bulletin 2014;(4):496-500,501
Aim Subcortical ischemic vascular demen-tia ( SIVD ) induced by chronic hypoperfusion due to small-artery disease is a common cause of vascular de-mentia ( VaD) , which is recognized as the second most prevalent type of dementia. The aim of this study was to determine whether carnosine played a protective role in cognitive impairment induced by permanent occlu-sion of the right unilateral common carotid arteries ( rUCCAO ) in SIVD. Methods Adult male mice ( C57BL/6 strain ) were subjected to rUCCAO, and treated with carnosine or saline. Locomotor test, open field test, hot plate test, freezing test and Morris water maze were performed after rUCCAO. Results There were no differences among rUCCAO group, carnosine group and sham group for total distance traveled in lo-comotor test. In the open field test, carnosine (200, 500 mg · kg-1 ) significantly revised the decrease of latency spent in the center induced by SIVD . There were no differences between rUCCAO and sham groups for the pain threshold. In freezing test, rUCCAO in-duced a significant reduction in content memory, which was completely reversed by treatment of carnosine. In Morris water maze training trials, rUCCAO-treated mice showed prolonged escape latency in acquisition phase, carnosine ( 200, 500 mg · kg-1 ) markedly shortened the escape latency. Conclusion These data suggest that carnosine has a neuroprotective effect on cognitive impairment induced by rUCCAO in mice.
9.Data Mining from Microarray Gene Expression Profile
Yuan-Hai YOU ; Jian-Zhong ZHANG ;
China Biotechnology 2006;0(10):-
Microarray technology are being performed more widely than ever before on many areas in lifescience,although the technology is still evolving,the challenge of performing a microarray experiment is no longer in the data generation,but in extracting useful information and utilizing it to get the results with biological meanings.Some methods and tools used for expressional microarray data mining based on previous work were summarized.These methods include gene clustering,GO analysis,regulating pathway analysis,and related algorithm.We hope this can be helpful for those researchers who are implementing expressional microarray for biological analysis.
10.Clinical study of standing bed for the orthostatic hypotension after cervical spinal cord injury
Jian-hong ZHANG ; Jian-zhong FAN ; FAN FAN ; Zhiqiang QI
Chinese Journal of Rehabilitation Theory and Practice 2002;8(5):298-299
ObjectiveTo observe the therapeutic effect of standing bed on orthostatic hypotension with cervical spinal cord injury. Methods36 patients with cervical spinal cord injury were divided randomly into the standing bed group and routine treatment group. The blood pressure of all patients were measured every day during rehabilitation treatment. The function of spinal cord was assessed before and after treatment.ResultsThe function of sensory and motor in the two groups were all improved, but there was no statistical difference between the two groups in the grades of spinal cord function. There were 27 patients who had orthostatic hypotension in the study. All the patients with complete spinal cord injury suffered the orthostatic hypotension. There was no improvement in blood pressure of complete spinal cord injury after treatment. In incomplete spinal cord injury patients, there was a significant improvement and the difference of blood presure between lying and standing was decreased in standing bed group after treatment (P<0.05). Compared with routine treatment group, the blood pressure in standing bed group was improved (P<0.05). Conclusions Cervical spinal cord injury could have orthostatic hypotension. Complete spinal cord injury would suffer orthostatic hypotension in different degree. The standing bed treatment could improve the orthostatic hypotension in incomplete spinal cord injury.