1.Imaging characteristics and clinical management of pancreatic duct stones
Yong CHEN ; Yong HE ; Jian ZHAO
Chinese Journal of Digestion 1996;0(05):-
Objective To investigate the imaging characteristics and to explore the clinical management of pancreatic duct stones. Methods The imaging characteristics and outcomes of different clinical management of 43 cases of pancreatic duct stones were retrospectively analyzed. Results In this group of patients with pancreatic duct stones, 42 cases were diagnosed by imaging examination, and 1 case was diagnosed during surgery. Among the 42 cases diagnosed by imaging, 20 cases were identified by B mode ultrasonography (BUS), 10 cases by CT, and 10 cases by ERCP. The pancreatic duct stones were located at the head of pancreas in 10 cases, at the body and tail of pancreas in 29 cases, and from the head to the tail of pancreas in 4 cases. Twenty patients with single pancreatic duct stones received conservative medical therapy, 6 patients with pancreatic duct stones located at the head of pancreas received endoscopic intervention therapy and 17 patients with multi pancreatic duct stones were successfully treated by surgery. Conclusions BUS, CT and ERCP are efficient means for diagnosing pancreatic duct stones. Choosing an appropriate management strategy based on the number, location and size of the stones is important for the successful treatment of pancreatic duct stones.
2.Clinical observation on auxiliary effect of xiaochuan paste in preventing repeated respiratory infection in child.
Jian CHEN ; Yong-qin ZHU ; Qin DONG
Chinese Journal of Integrated Traditional and Western Medicine 2002;22(8):620-621
Administration, Cutaneous
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Amoxicillin
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therapeutic use
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Child
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Child, Preschool
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Drug Therapy, Combination
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Drugs, Chinese Herbal
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administration & dosage
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Female
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Humans
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Male
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Penicillins
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therapeutic use
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Phytotherapy
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Respiratory Tract Infections
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drug therapy
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prevention & control
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Secondary Prevention
4.Transforming growth factor-β1 induces the expressions of twist protein in kidney tubular epithelial cells through Akt pathways
Yong ZHANG ; Liping WANG ; Jian CHEN
Journal of Chinese Physician 2013;(4):441-444
Objective To investigate whether transforming growth factor-β1 (TGF-β1) could induce the expression of twist protein in the human kidney tubular epithelial cells (HKCs).Methods Human proximal HKCs were cultured in vitro and divided into three groups as follows:control group,TGF-β1group (10 ng/ml),and TGF-β1 + wortmannin group (10 ng/ml,10nmol/l,respectively).After cultured for 48 hours,cell immunofluorescene was used to observe the expression of E-cadherin and alpha-smooth muscle actin (α-SMA).Meanwhile,Western blotting was used to detect the protein expression of E-cadherin,α-SMA,and twist.Results Compared to control group,the protein expressions of E-cadherin were significantly decreased in T group (3.54 ± 0.17 vs 16.06 ± 0.50,P =0.001),whereas the protein expressions of α-SMA and twist were significantly increased in T group (α-SMA:14.78 ± 0.48 vs 3.75 ± 0.50,P=0.001 ;twist:14.24 ±0.14 vs 3.06 ±0.15,P =0.001).Compared to T group,a significant increase of the E-cadherin protein expression was detected in TGF-β1 + wortmannin group (15.88 ± 0.36,3.46 ±0.19,P =0.001),whereas,the protein expressions of α-SMA and twist were significantly decreased in TGF-β1 + wortmannin group (α-SMA:3.50 ±0.39 vs 15.0 ±0.24,P =0.001 ;twist:3.09 ±0.1 vs 14.04± 0.16,P =0.001).Cell imunofluorescence showed that the expressions of E-cadherin and α-SMA were consistent with the results of Western blotting.Conclusions TGF-β1 can induce the expression of twist protein in HKCs through Akt pathways.
5.Ischemic Tolerance and Expression of Hypoxia Inducible Factor-1? in PC12 Cells Induced by Acanthopannx Senticosus Saponins
jian, CHEN ; li, ZHU ; yong-jin, PAN
Journal of Applied Clinical Pediatrics 2006;0(24):-
Objective To study ischemic tolerance induced by acanthopannx senticosus saponins(ASS) on ischemia in PC12 cells and involve expression of hypoxia inducible factor-1?(HIF-1?).Methods An ischemic model was developed in PC12 cell line with treatment of oxygen glucose deprivation(OGD).The protective effects of ASS pretreatment on ischemic tolerance of PC12 cells and whether protective effects of ASS could be inhibited by LY294002(PI3K inhibitor) were analyzed through MTT assay.The induction of phospho-glycogen synthesis kinase-3?(p-GSK-3?) and HIF-1? after pretreatment of ASS and possible blocking effects of LY294002 were detected by Western-blot.Results MTT results showed that after 9 h ischemia,the viability of PC12 cells decreased dramatically(P
6.27 clinical survey of ~(131)I cure Graves disease combined with liver damage
Weizhen YANG ; Yong CHEN ; Jian GENG
Chinese Journal of Primary Medicine and Pharmacy 2006;0(01):-
Objective To observe liver function improvement of Grave's disease combined with liver damage after ~(131)I cure.Methods We observed patients of Graves disease combined with liver damage on diffevent times after ~(131)I cure(3,6,12,24 months after ~(131)I cure) and at the same time we monitored liver function.Results The liver function and clinical expression of the patients who had Graves disease combined with liver damage improved vemarkably after ~(131)I cure.Conclusion ~(131)I cure Graves patients combined with liver damage is safe and simple and has long-term effect.It's side effect is little and is apt to be accepted by patients.
7.Therapeutic effect of Huangkui Capsule on IgA nephropathy with damp-heat syndrome
Liping WANG ; Yong ZHANG ; Jian CHEN ; Yongze ZHUANG ; Jian DU
Chinese Traditional Patent Medicine 1992;0(01):-
0.05).No severe adverse event occurred during the treatment,and the occurrence in the two groups was similar.CONCLUSION:Huangkui Capsule can effectively decrease the proteinuria just like fosinopril and improve clinical syndrome of patients of IgA nephropathy with damp-heat syndrome type,and shows no serious adverse reaction.
8.Continuous intravenous infusion of midazolam for treatment of status epilepticus in children.
Jian-min ZHONG ; Jian-hua LI ; Yong CHEN
Chinese Journal of Pediatrics 2004;42(4):299-300
Adolescent
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Age Factors
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Anti-Anxiety Agents
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administration & dosage
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adverse effects
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therapeutic use
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Infusions, Intravenous
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Male
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Midazolam
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administration & dosage
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adverse effects
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therapeutic use
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Status Epilepticus
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drug therapy
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Treatment Outcome
9.Therapeutic effect of Huangkui Capsule on IgA nephropathy with damp-heat syndrome
Liping WANG ; Yong ZHANG ; Jian CHEN ; Yongze ZHUANG ; Jian DU
Chinese Traditional Patent Medicine 2010;(1):18-21
AIM:To observe the clinical effects of Huangkui Capsule (Abelmoschus manihot (Linn)Medic.)on the treatment of IgA nephropathy of damp-heat syndrome.METHODS: Sixty-four patients were assigned randomly into two groups: treatment group in which 32 cases were treated with Huangkui Capsule,and control group,in which 32 cases were treated with fosinopril.The therapeutic course for both groups was 12 weeks.The indexes of efficacy ,including damp-heat syndrome scores,24 h urinary protein,serum creatinine,urea nitrogen and the indexes of safety,including liver function,electrolyte and occurrence of adverse events were observed.RESULTS :There was no significant statistical difference between the two groups in aspects of baseline clinical figures,after 12 weeks of treatment,the content of 24h urinary protein significantly decreased by (0.49±0.78 )g/24 h and (0.4±0.76 ) g/24 h respectively in the two groups,showing significant difference in comparing with baseline,but insignificant difference between the two groups ( P > 0.05 ),the scores of damp-heat syndrome in the two groups decreased by (0.88±1.43 ) scores and (1.94±1.63 ) scores respectively with significant difference as compared with baseline (P <0.05 ),and in comparison between groups(P <0.05 ).The total effective rate of 24 h urinary protein was 53.1% in the treatment group and 65.6% in the control group (P > 0.05 ),The total effective rate of dampheat syndrome scores was 84.4% in the treatment group and 50% in the control group ( P > 0.05 ).No significant change in levels of serum creatinine,urea nitrogen in the two groups was found (P >0.05 ).No severe adverse event occurred during the treatment,and the occurrence in the two groups was similar.CONCLUSION: Huangkui Capsule can effectively decrease the proteinuria just like fosinopril and improve clinical syndrome of patients of IgA nephropathy with damp-heat syndrome type,and shows no serious adverse reaction.