2.Dynamic expression of transforming growth factor-beta1 mRNA and protein and its inhibitory effect on lung development in premature rat with chronic lung disease.
Chinese Journal of Pediatrics 2005;43(6):463-465
Animals
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Chronic Disease
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Disease Models, Animal
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Female
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Gene Expression Regulation, Developmental
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Hyperoxia
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Immunohistochemistry
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Lung
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growth & development
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metabolism
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Lung Diseases
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metabolism
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Oxygen
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Pregnancy
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RNA, Messenger
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metabolism
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Rats
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Rats, Sprague-Dawley
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Reverse Transcriptase Polymerase Chain Reaction
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Transforming Growth Factor beta1
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genetics
;
metabolism
3.Expression and Effect of Cyclin Dependent Kinase-4 and p21 in Premature Rats with Hyperoxia-Induced Chronic Lung Disease
Journal of Applied Clinical Pediatrics 2004;0(11):-
Objective To investigate the dynamic change of expression of cyclin dependent kinase-4(CDK4)and cyclin dependent kinase inhibitor(p21)in premature rats with hyperoxia-induced chronic lung disease(CLD)and its role.Methods Eighty premature rats were randomly and equally divided into model group(hyperoxia group)and control group(room air group).CLD was induced by hypemxia exposure.The expression of CDK4 and p21 were observed with immunohistochemical method,and the levels of type I collagen were detected by enzyme-linked immunosorbent assay on days 1,3,7,14 and 21.Results Compared with control group,in model group,the expression of CDK4 protein and level of type I collagen statistically increased,but expression of p21 protein decreased significantly on days 14 and 21.The expression of CDK4 was positive correlated with the degree of fibrosis,and expression of p21 was negative correlated with the degree of fibrosis in model group.Conclusion The expression of CDK4 increases and expression of p21 decreases in premature rats exposed to hyperoxia,which may play an important role in the lung fibrosis.
6.Clinical value of urethral dilation in treatment of female bladder outlet obstruction
Baoguo LI ; Wensheng WANG ; Xin LI ; Gang ZHANG ; Jian XUE
Chinese Journal of Postgraduates of Medicine 2016;39(10):919-921
Objective To explore the clinical value of urethral dilation in treatment of female bladder outlet obstruction. Methods Thirty-five female bladder outlet obstruction patients were selected, and all the patients failed for more than 1 month inαreceptor blocker treatment. The patients underwent urethral dilation under local anaesthesia, once a week, for a total of 12 times. The international prostate symptom score (IPSS), quality of life score (QOL) and residual urine volume before and after treatment were examined. Results The IPSS, QOL and residual urine volume after treatment were significantly lower than those before treatment: (10.23 ± 6.31) scores vs. (21.41 ± 3.71) scores, (2.31 ± 0.65) scores vs. (5.43 ± 0.60) scores and (20.73 ± 10.59) ml vs. (85.23 ± 12.15) ml, and there were statistical differences (P<0.01). Conclusions The urethral dilation is one of the effective treatments for female bladder outlet obstruction patients who fail in αreceptor blocker treatment. It can make a part of patients avoid invasive examination and surgery, and it is worth to be popularized in clinic and primary hospital.
8.A case of tuberous sclerosis complex in newborn infant.
Ling-ling HU ; Jian-hua FU ; Xin-dong XUE
Chinese Journal of Pediatrics 2013;51(2):156-157
Brain
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pathology
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Humans
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Infant, Newborn
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Lung
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pathology
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Male
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Seizures
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etiology
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pathology
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Tomography, X-Ray Computed
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Tuberous Sclerosis
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complications
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pathology
9.Early radiological changes and effect on prognosis in preterm infants with cerebral white matter damage.
Chang LIU ; Jian-hua FU ; Xin-dong XUE
Chinese Journal of Pediatrics 2012;50(10):762-766
Brain
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diagnostic imaging
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pathology
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Cerebral Palsy
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diagnosis
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pathology
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Cognition Disorders
;
diagnosis
;
pathology
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Early Diagnosis
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Humans
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Infant, Newborn
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Infant, Premature
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Infant, Premature, Diseases
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diagnosis
;
pathology
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Language Disorders
;
diagnosis
;
pathology
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Leukomalacia, Periventricular
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complications
;
diagnosis
;
pathology
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Magnetic Resonance Imaging
;
methods
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Prognosis
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Radiography
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Severity of Illness Index