1.Advances of associating liver partition and portal vein ligation for staged hepatectomy in the treatment of primarilly unresectable liver cancer
Yuanfei PENG ; Zheng WANG ; Jian ZHOU
Chinese Journal of Digestive Surgery 2021;20(2):155-162
In recent years, the systematic treatment of liver cancer has made significant progress, but surgical resection remains as main treatment to obtain long-term survival for patients with liver cancer. With the rapid development of liver surgery, the complexity of liver anatomy and surgical operation are no longer the main obstacles to liver surgery. The insufficient future liver remnant (FLR) after hepatectomy has become the main limit of liver surgery. In clinical practice, most patients with liver cancer cannot undergo one-stage radical resection and can only receive non-surgical treatment, with poor long-term prognosis. The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) provides hope for the treatment of liver cancer patients with insufficient FLR. ALPPS can induce significant hypotrophy of the FLR in a short period of time, and the radical tumor resection rate is as high as 90% to 100%, which significantly improves the prognosis of patients. However, in the early stages of the practice, there were considerable controversies on the safety of the operation. In recent years, with the continuous advancement of technology, the safety of ALPPS has been greatly improved. The authors synthesize the latest literatures and elaborate on the latest progress of ALPPS.
2.A retrospective study of the clinical features in papillary thyroid microcarcinoma
Wei ZHENG ; Jian TAN ; Guizhi ZHANG ; Peng WANG ; Renfei WANG
Chinese Journal of Endocrinology and Metabolism 2015;31(1):14-17
Objective To identify clinical features of papillary thyroid microcarcinoma(PTMC) according to patients' age.Methods Seventy-eight patients with PTMC were divided into 2 groups according to age:≥45 years and <45 years.The clinical data were retrospectively analyzed.Results The average preoperative thyroglobulin (Tg)level in <45 years group was apparently higher than that in ≥45 years group[(138.61 ± 91.87 vs 80.20 ± 85.00) μg/L,P<0.01].The average tumor size in <45 years group was apparently larger than that in ≥45 years group [(0.64 ± 0.24 vs 0.45 ± 0.25) cm,P<0.01].There were more patients with multiple cancer foci in <45 years group than in ≥45 years group (73.53% vs 45.45%,P<0.05).And there were more patients with cancer in bilateral lobes in <45 years group than that in ≥45 years group(44.12% vs 18.18%,P<0.05).There were no significant differences in preoperative thyroid stimulating hormone level,preoperative thyroglobulin antibody (TgAb)level,incidence of capsular invasion of cancer,neck lymph nodes involvement,distant metastasis,and backgrounds of benign thyroid diseases between two groups (all P>0.05).Conclusion The patients with PTMCs had different clinical features according to age.Hence,clinicians should consider an individualized treatment according to age in order to achieve better therapeutic efficacy.
3.Advances in ultrasonic assessment of bone status and osteoporosis
Jian ZHANG ; Hu PENG ; Renjie ZHOU ; Chichao ZHENG
International Journal of Biomedical Engineering 2011;34(3):179-183
Research on osteoporosis diagnosis has always been a critical isuue in the field of international academia and medicine. Recent progress in quantitative ultrasound (QUS) has suggested that ultrasound, due to its obvious advantages, be considered as an effective and noninvasive tool for assessment of bone status and diagnosis of osteoporosis. This paper presents the principle and recent development in the ultrasonic assessment of bone status and osteoporosis including assessment with through-transmission and backscattering measurement, and also introduces the latest progress in ultrasonic axial transmission technique.Limitations of current research are discussed and suggestions are proposed for future research.
4.Correlation Study Between Serum Soluble ST2 Level and the Early Clinical Prognosis in Patients With Acute ST-elevation Myocardial Infarction
Lei HE ; Jian PENG ; Xuan ZHENG ; Chengwei LIU ; Xi SU
Chinese Circulation Journal 2017;32(1):41-45
Objective: To preliminarily investigate the relationship between the baseline level of serum soluble ST2 (sST2) and 30-day MACE occurrence rate in patients with ST-elevation myocardial infarction (STEMI).
Methods: A total of 121 patients with confirmed diagnosis of STEMI in our hospital from 2015-05-01 to 2015-07-30 were consecutively enrolled. According to baseline sST2 level, the patients were divided into 2 groups:Low sST2 group, the patients with sST2≤56.68 ng/ml, n=61 and High sST2 group, the patients with sST2>56.68 ng/ml, n=60. Clinical condition and 30-day MACE (defined as death and new onset of congestive heart failure) occurrence rate were compared between 2 groups.
Results: ① The systolic blood pressure (SBP), Killip class≥II grade, blood levels of cTNI, NT-proBNP, hs-CRP and LVEF were different between 2 groups, all P<0.05. ② Baseline sST2 level was positively related to heart rate (r=0.271, P=0.003), Hs-CRP (r=0.359, P=0.000), cTNI (r=0.324, P=0.000) and NT-proBNP (r=0.425, P=0.000);negatively related to SBP (r=-0.226, P=0.013) and LVEF (r=-0.406, P=0.000).③30-day MACE occurrence rate was different between 2 groups (8.2%vs 30%, P=0.002). ④ Multivariate Cox regression analysis presented that sST2>56.68 ng/ml was the risk factor for 30-day MACE occurrence (HR=1.152, 95%CI 1.078-1.231, P=0.000).
Conclusion: Increased baseline level of sST2 implied the higher incidence of death and new onset of congestive heart failure in STEMI patients.
5.The effect of modified pericardial devascularization on esophageal gastric varices of liver ;cirrhosis with portal hypertension
Peng ZHENG ; Jian ZHOU ; Yongshuang LYU ; Tianwu YU
Chinese Journal of Postgraduates of Medicine 2017;40(2):161-163
Objective To explor the operative method of modified pericardial devascularization and compare the effects of modified pericardial devascularization and traditional pericardial devascularization on esophageal gastric varices of liver cirrhosis with portal hypertension. Methods The clinical data of 35 patients receiving modified pericardial devascularization (MED group) and 35 patients receiving traditional pericardial devascularization (ED group) were retrospectively analyzed . Results The operating time in MED group was significantly lower than that in ED group:(182 ± 30)min vs.(220 ± 30) min, P<0.05. The blood loss in MED group was significantly lower than that in ED group:(200 ± 15) ml vs. (300 ± 100) ml, P<0.05. Early complication rate in MED group was significantly lower than that in ED group:5.7%(2/35) vs. 22.9%(8/35), P<0.05. The esophageal gastric varices of patients who were followed up in MED group and ED group were almost equal (P>0.05). Conclusions The operating time, blood loss and early complication rate in modified pericardial devascularization is better than traditional pericardial devascularization. There is no significant difference in long-term efficacy between two methods.
6.Antitumor effect of chlorophyllin in vitro
Xiaowen DING ; Shu ZHENG ; Jiaping PENG ; Qinghua L ; Jian HUANG
Chinese Journal of Pathophysiology 1999;0(09):-
AIM: To study the effect and mechanism of chlorophyllin (CHL) inhibiting HT29 cells. METHODS: IC 50 value and growth curve of HT29 cells were detected with MTT method. Apoptosis was detected with Wright-Giemsa staining, FCM and DNA electrophoresis. Telomerase was detected by PCR-ELISA, and protein and mRNA expression of COX-2 gene were detected through RT-PCR and Western blot. RESULTS: CHL inhibited the growth of HT29 in a dose-dependent manner. CHL blocked HT29 cells in G 1 phase but did not induce apoptosis. Different concentration of CHL inhibits the expression of telomerase and COX-2 in HT29 cells. CONCLUSION: CHL inhibits the growth of HT29 cells by inhibiting the expression of telomerase and COX-2 and blocking cells in G 1 phase. [
7.Clinical Observation on Post-stroke Elbow Flexor Spasticity Treated with Massage
Peng ZHENG ; Xiaohong XU ; Weimin ZHANG ; Jian WANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(5):1029-1031
This article was aimed to observe the therapeutic effect of massage manipulation in the treatment of post-stroke elbow flexor spasticity . Stroke cases that met the inclusion criteria were selected . The cases were randomly divided into the treatment group of 48 cases and the control group of 48 cases . The treatment group was treated with massage . And the control group was treated with continuous static stretch technique . The re-sults showed that there was significant difference before and after the treatment in both groups. And the treat-ment group was significantly better than the control group ( P < 0 . 05 ) . It was concluded that massage manipu-lation has obvious effect in the treatment of post-stroke elbow flexor spasticity.
8.Detection of MCP-1, MSP and carcinoembryonic antigen in differential diagnosis of pulmonary tuberculosis and lung cancer
Chunxian PENG ; Xiaoyan ZHENG ; Jian FAN ; Xiangmin TONG
Chinese Journal of Clinical Infectious Diseases 2013;6(6):331-334
Objective To investigate the detection of monocyte chemotactic protein 1 (MCP-1),macrophage stimulating protein (MSP) and carcinoembryonic antigen (CEA) in differential diagnosis of pulmonary tuberculosis and lung cancer.Methods Thirty four patients with pulmonary tuberculosis,45 patients with pathologically confirmed lung cancer admitted in Quzhou People' s Hospital during December 2009 and December 2011,and 30 healthy controls were enrolled in the study.MCP-1 and MSP in serum and pleural effusion were determined by enzyme linked immunosorbent assay (ELISA),and CEA was detected by chemiluminescence method.Receiver operating characteristic method was used to determine the cut-off values of MCP-1,MSP and CEA in diagnosis of pulmonary tuberculosis or lung cancer.Results Serum MCP-1,MSP and CEA levels in pulmonary tuberculosis patients and lung cancer patients were higher than those in healthy controls.Compared with lung cancer patients,patients with pulmonary tuberculosis had higher serum MCP-1 and lower CEA levels (t =2.69 and 0.89,P < 0.05),but there was no significant difference in serum MSP levels between two groups (t =2.89,P > 0.05).While in pleural effusion,patients with pulmonary tuberculosis had higher MCP-1 level (t =3.54,P < 0.05),lower MSP and CEA levels than those with lung cancer (t =3.47 and 3.48,P < 0.05).Serum MCP-1 level was of the highest specificity (95.6%) with the cut-off value of 240 pg/mL in diagnosis of pulmonary tuberculosis,while MSP level in pleural effusion was of the highest specificity (94.1%) with the cut-off value of 1100 pg/mL in diagnosis of lung cancer.Conclusion Detection of MCP-1,MSP and CEA in serum and pleural effusion can be used for the differential diagnosis of pulmonary tuberculosis and lung cancer.
9.Protective effect of pergolide on parkinsonian model rats
Jian WANG ; Guoguang PENG ; Min ZHENG ; Haiyan LUO
Chinese Pharmacological Bulletin 2003;0(11):-
Aim To explore the antioxidation of pergolide on rat models of Parkinson disease and its mechanism. Methods Wistar rats were pretreated daily with pergolide(1.0 mg?kg -1,ip),pergolide combined with sulpiride(25 mg?kg -1) or sulpiride alone for 7 days, and then sacrificed by decapitation. The activity of SOD and GSH in striatum was determined. Unilateral Parkinsonian models were made in rest of the rats by stereotaxically injecting 6-OHDA. After two weeks, apomorphine (APO)-induced rotational behavior of each group was compared, and the concentrations of striatal dopamine (DA),dihydroxyphenyl acetic acid(DOPAC) and homovanilic acid(HVA) were determined by high performance liquid chromatography (HPLC). Result Administration of pergolide for 7 days significantly increased the act- ivities of SOD and GSH in the striatum (P
10.Preparation and stability test of Lyophiled Royal Jelly Soft Capsule
Jian HE ; Tao PENG ; Meiling DAI ; Zheng JIANG ; Chunhui LIU
Chinese Traditional Patent Medicine 1992;0(12):-
AIM:To prepare the Lyophiled Royal Jelly Soft Capsule and study its stability and Influential factors.METHODS:The suspending agent and processing method were optimized using sedimentation volume rate as the index.Soft capsules were prepared and product stability under high temperature and high humidity environment was studied according to the determination of the content of 10-HAD by HPLC.RESULTS:The finished product yield in pilot test was more than 90%,the soft capsule products stored in cold were stable,while those stored under room temperature or high temperature and high humidity were unstable with a noticeable decrease in quality.Water content in capsule shell affects the 10-HDA content of the finished product.CONCLUSION:The preparative process is feasible and the products should be storaged in cold enviroment.