Objective To understand the current status of intestinal helminth infections in Dafeng City. Methods The resi?dents in 5 villages of Dafeng City were investigated and their stool samples were detected for the eggs of helminth with Kato?Katz technique and Enterobius vermicularis was detected by the cellophane anal swab method. Results The total infection rates of intestinal helminth were 5.77% 5.51% 4.60% 4.18% 3.41% and 1.38% from 2005 to 2010 respectively. The trend of total infection rates declined year by year. The infection rates in the 20?30 age?group and 60?80 age?group were higher than those in other age?groups. The infection rates of the male and female were 5.63 359/6 375 and 2.42 144/5 949 re?spectively and there was a significant difference χ2=74.81 P=0.00 . The infection rate 11.70% in the northern areas of Dafeng City was higher than that in other places and the trend of the infection rates decreased from the eastern and northern to the western and southern. The infection rate of E. vermicularis was 1.75%in children in 2010. Conclusions The infection rate of intestinal helminth is low but E. vermicularis infection is relatively general in the children in Dafeng City. Therefore the pre?vention and treatment still need to be strengthened.

Glucocorticoid(GC) /glucocorticoid receptor(GR) inhibits cell proliferation and protects cells from apoptosis induced by serum deprivation,hypoxia,irradiation or chemotherapy drugs in many cell types,thereby GC/GR can maintain cell number homeostasis,which is an important aspect of homeostasis regulation of GC/GR in higher organisms.This article reviews antiproliferative and antiapoptotic effects of GC/GR on cell and their molecular mechanism,mainly focusing on the molecular events and target genes downstream of GC/GR.

Humans ; Multiple Myeloma ; Neoplasm Recurrence, Local

Objective Vessel overload index (VOI)was studied to monitor patients with hypertensive cerebral hemorrhage.Methods 144 cases with hypertensive cerebral hemorrhage were divided into two groups at random.One group was treated with mannitol plus urapidil hydrochlorid and the other with mannitol alone as controls.VOI were observed before and 2～4 hours after treatment and the changes of VOI values were analyzed with t-test.Results There was no significant difference in VOI values between groups before treatment (P＞0.05),but after treatmen (P＜0.05),30 day mortality was 18.18% in controls and 8.7% in observed groups.Conclusion VOI can be used to evaluate vessel load in hypertensive patients with cerebral hemorrhage and to indicate hypotensive therapy properly.

Primary intrahepatic stone is a common disease in China. It is difficult to treat this benign biliary tract disease because it has many complications and the surgery is difficult. Understanding the cause of this disease has important implications in prevention and treatment. This article reviewed the cause of primary intrahepatic stone from four aspects: imbalance of bile components, infection, bile protein, and macromolecular and metabolism of the cells.

ObjectiveTo imitate the process of identifying episode separations,which helps to improve the methodology of control episode separations.Methods Abstracts of inpatient record on all patients discharged from the hospitals in Beijing in 2010 were drawn from Beijing Public Health Information Center.Risk-adjusted by Diagnosis Related Groups-Beijing version (BJ-DRGs),two-weeks readmission rate was calculated at the whole city and hospital levels respectively.Comparing the readmission rate between these two levels,“suspicious objects”of episode separations can be found.In turn,the episode separations can be identified by detail analysis of these suspicious objects.Results In 2010,there were 13 DRGs with readmission rate exceeding 10％.Take the cases of dementia and other chronic brain disorders for example,the readmission rate for this type of inpatients in hospital G was much higher than the average level of the whole city.After the detail analysis of hospital G,the episode separations were found.Conclusion It is an effective method to indentify episode separations that calculating readmission rate based on the DRG risk-adjustment and using city level readmission rate as bench-mark.

Objective To get a better understanding of the characteristic MRI appearances of cerebral MS lesions.Methods 61 patients with clinically diagnosed multiple sclerosis were examined with SE sequences,using 0.5T super-conducting scanner.The MRI features of MS were analyzed.Results All of the patients in 61 cases were found MS lesions in MRI.The lesions in cerebral,brainstem,and cerebellum were clearly visualized,but in optic nerves were not so good.The MS foci appeared low or middle signal intensity in T 1WI and high signal intensity in T 2WI.It was playing an important role in the diagnosis of the MS that the paraventricular lesions were perpendicular to the lateral ventricles and there were MRI abnormal signals in corpus callosum with shrinking. Conclusion MRI can show the characteristic appearances of MS lesions,demonstrate many more lesions that not visible on CT scan,provide informations about the number,size,location and extent of the lesions therefore MRI is the first method of choice in the diagnosis of MS.

Purpose:To investigate whether transforming growth factor ?1 (TGF ?1) pathway is involved in the mechanism of dexamethasone (Dex) mediated proliferation inhibition in ovarian cancer cell line HO 8910.Methods:To analyse cell proliferation and cell cycle distribution by cell counts and flow cytometric analysis, respectively ; to determine the expression levels of TGF ?1 and its two receptors, T?R Ⅰ and T?R Ⅱ , by quantative RT PCR, ELISA and(or) immunocytochemistry methods.Results:Dex induced a G 0 /G 1 cell cycle arrest in HO 8910 cells, and it up regulated T?R Ⅱ expression in a concentration dependent manner.The level of T?R Ⅱ mRNA was the highest after treatment with Dex for 8 hours, with 1.4 fold more than that of control at concentration of 10 -7 mol/L ( P

AIM: To study the protection effect of baicalin on isoproterenol (ISO) induced myocardial ischemia in rats and its mechanisms. METHODS: Forty-five Sprague-Dawley rats were randomly divided into 3 groups. The rats in control group (n=15) received no treatment. The rats in ISO group (n=15) received two times of subcutaneous injection of ISO (20 mg?kg~ -1), which was separated by a 24 hours-interval. The rats in baicalin group (n=15) received ISO as described above and received baicalin 50 mg?kg~ -1 ip. simultaneously. Two days later the hemodynamic measurement was performed and the serum levels of LDH, CK and TNF-? were detected. The expression of p38mapk in myocardium was detected by immunohistochemical technique. RESULTS: The heart function of the group treated with baicalin was improved significantly compared with that of control group. The levels of LDH, CK and TNF-? in baicalin group decreased significantly compared with those in control group and the expression of p38mapk in myocardium also decreased markedly. CONCLUSION: Baicalin has protection effect on isoproterenol induced myocardial ischemia in rats, and the effect maybe due to the decrease of TNF-? induced by reducing the p38mapk expression.

OBJECTIVE: To containment the unhealthy tendency in drug purchase and to promote the healthy and harmonious development of heath service.METHODS: Honest government risk prevention & control pattern was established in our hospital,and the system construction was strengthened,furthermore,a scientific operation flow was formulated,and a system of rewards and disciplinary evaluation was established.RESULTS: With the honest government risk prevention & control pattern,the centralized public bidding was achieved in 100% of the hospital drug purchasing,the clinical drug use tends to be more and more rational and standard,and the drug use structure became more reasonable,the honest government risk in drug purchase and sale has been effectively avoided.CONCLUSION: This honest government risk prevention & control pattern is practical and feasible thus deserving popularized in medical institutions.