1.Clinical Application of Pediatric Risk of Mortality Score in Pediatric Intensive Care Unit
jian-hui, ZHANG ; qi-yi, ZENG ; jian-ping, TAO
Journal of Applied Clinical Pediatrics 1992;0(06):-
15, the mortality was38.1%(n = 8).There was significantly difference both in mortality (x2 = 4.14 P
2.Clinical study of prevention of oxaliplatin-induced acute neurotoxicity by calcium and magnesium infusions
Jian-Hua YU ; Hui-Ping WAN ; Jian-Yong YU ;
Cancer Research and Clinic 2000;0(06):-
Objective To evaluate the efficacy of calcium(Ca)and magnesium(Mg)infusions in pre- vention of oxaliplatin-induced acute neurotoxicity.Methods Fourty-two patients with advanced colorectal carcinoma were eligible for the study:21 were assigned to the Ca/Mg ann and 21 to the control arm.The Ca/ Mg arm and the control arm were comparable for patients'characteristics.Chemotherapy regimen were al- most the same in both arms.Chemotherapy regimen consisted of oxaliplatin 130 mg/m~2 on day 1,given as a 3-hour infusion in 500 ml of 5% glucose,concurrent with rahitrexed 3 mg/m~2 as a 15-minute intravenous (Ⅳ)infusion or calcium folinate(CF)200 mg?m~(-2)?d~(-1),days 1~5,5-Fluorouracil(5-Fu)500 mg?m~(-2)?d~(-1),days 1~5.Therapy was repeated every 3 weeks.The treatment consisted of Ca gluconate and Mg sulfate,1 g each, delivered i.v.over 15 min just before the oxaliplatin infusion and repeated at the same dose after the comple- tion of the oxaliplatin infusion.A specific neurotoxicity scale was used for oxaliplatin-related neurotoxicity. Results Ten patients(47.62%)had acute neurotoxicity in the Ca/Mg arm compared with 19 patients (90.48%)in the control arm(P0.05).Conclusion Ca/Mg infusions seem to reduce incidence and intensity of oxaliplatin-induced acute neurotoxicity,and they do not reduce the clinical activity of oxaliplatin,but dosage and administration schedule could be optimized.
4.The role of glucocorticoid in treating cytomegalovirus pneumonia following renal transplantation
Jian-Ping ZHAO ; Ge-Hui ZHOU ; Hui-Lan ZHANG ;
Chinese Journal of Organ Transplantation 2005;0(11):-
Objective To study the role of glucocorticoid (GC) in treating patients with cyto- megalovirus (CMV) pneumonia following renal transplantation.Methods There were 75 cases CMV pneumonia following renal transplantation during one month (3 cases),2-6 months (64 cases) and more than 6 months (8 cases).All patients were subjected to the comprehensive treatments including anti-virus therapy.In 47 cases,GC was given (GC group),and in the rest 28 cases,GC was not administered (non-GC group).Results In GC group,40 cases (85.1%) were cured and there were 7 deaths (14.9%).In non-GC group,17 cases (60.7%) were cured and there were 11 deaths (39.3%).There was significant difference between two groups (P
5.Influential factors of systemic lupus erythematosus activity during pregnancy and its relationship with pregnancy outcome
Yun-Hui WANG ; Xiao-Xia WU ; Jian-Ping TAN ; Jian-Ping ZHANG ;
Chinese Journal of Obstetrics and Gynecology 2000;0(09):-
Objective To investigate the influential factors of systemic lupus erythematosus(SLE) activity during pregnancy and their relationship with pregnancy outcome.Methods A retrospective analysis of the clinical history of 66 pregnant women with SLE from 1991 to 2005 was carried out.Results(1) Those patients with unstable status progestation,patients being newly diagnosed with SLE during pregnancy or patients irregularly using prednisone became active during pregnancy.The disease was active in 32 cases(the active group)and inactive in 34 cases(the inactive group).(2)Obstetric complications in the active group included:9 cases of preeclampsia,13 cases of fetal growth restriction(FGR),7 cases of therapeutic abortion and 15 cases of premature labor;and the corresponding numbers in the inactive group were 1,5,1 and 4, respectively.All the numbers were significantly different between the two groups(P
6.Study on challenge dose of pigeon paramyxovirus type 1 (Chuansha strain).
Jun-Ping ZHANG ; Hui-Ping YANG ; Feng-Ying JIANG ; Jian-Ping NI ; Chun-Hua LI
Chinese Journal of Virology 2014;30(2):177-179
In order to determine the challenge dose of pigeon paramyxovirus type 1 (PPMV-1) inactivated vaccine (S-1 strain). The virus titer of PPMV-1 E5 allantoic fluid (Chuansha strain) was determined using SPF chicken embryos in this research. After inoculating 30-day-old and 120-day-old pigeons with low-HI antibody against PPMV-1 (HI antibody < or =2) with different doses of PPMV-1 (Chuansha strain), the clinical symptoms and histopathological lesions of the challenged pigeons were examined. The results showed that the minimal lethal dose (MLD) of PPMV-1 (Chuansha strain) was 102.5 ELD50, so we determined that 10(5.5) ELD50, which was 1000 times the MLD, could be taken as the challenge dose in the vaccine efficacy test for PPMV-1 inactivated vaccine (S-1 strain).
Animals
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Antibodies, Viral
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immunology
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Bird Diseases
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immunology
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mortality
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virology
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Chick Embryo
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Columbidae
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immunology
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virology
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Newcastle Disease
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immunology
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mortality
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virology
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Newcastle disease virus
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immunology
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pathogenicity
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Phylogeny
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Viral Vaccines
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immunology
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Virulence
10.Modified Technology Readiness Level for Advanced Medical Devices in China
Zhaolian OUYANG ; Ping ZHOU ; Jian DU ; Hui CHI
Chinese Journal of Medical Science Research Management 2015;28(3):217-221
Technology readiness level (TRL) refers the general maturity level of a single technology or technical systems (including technology,component or subsystem) during the process of development.Base on the original TRL proposed by NASA,with reference to medical device TRL modified by US Department of Defense and NATO,this study modified TRL definition and description for advanced medical devices with consideration of R&D,review and approval characteristics of advanced medical devices in China.