Objective To get a better understanding of the characteristic MRI appearances of cerebral MS lesions.Methods 61 patients with clinically diagnosed multiple sclerosis were examined with SE sequences,using 0.5T super-conducting scanner.The MRI features of MS were analyzed.Results All of the patients in 61 cases were found MS lesions in MRI.The lesions in cerebral,brainstem,and cerebellum were clearly visualized,but in optic nerves were not so good.The MS foci appeared low or middle signal intensity in T 1WI and high signal intensity in T 2WI.It was playing an important role in the diagnosis of the MS that the paraventricular lesions were perpendicular to the lateral ventricles and there were MRI abnormal signals in corpus callosum with shrinking. Conclusion MRI can show the characteristic appearances of MS lesions,demonstrate many more lesions that not visible on CT scan,provide informations about the number,size,location and extent of the lesions therefore MRI is the first method of choice in the diagnosis of MS.

Primary intrahepatic stone is a common disease in China. It is difficult to treat this benign biliary tract disease because it has many complications and the surgery is difficult. Understanding the cause of this disease has important implications in prevention and treatment. This article reviewed the cause of primary intrahepatic stone from four aspects: imbalance of bile components, infection, bile protein, and macromolecular and metabolism of the cells.

Objective To observe the expression of CD_(25),CD_(25) mRNA,interleukin-1?(IL-1?) in peripheral blood of newborns with hypoxic-ischemic encephalopathy(HIE) and its clinical significance.Methods The peripheral blood mononuclear cells(PBMC) of newborns with HIE and normal controls were isolated by routine Ficoll-Hypaque,and the level of CD_(25) induced and non-induced by phytohernagglutinin(PHA) were detected by biotin-streptavidin(BSA),CD_(25) mRNA was detected by real-time PCR and IL-1? in serum was detected by enzyme-linked immunosorbent assay on the first,third and seventh day after birth.The final expressive level of CD_(25) mRNA was based on rate of CD_(25) cDNA and gluceraldehyde phosphase dehydrogenase(GAPDH).Results On the first day,the positive rates of CD_(25) induced and non-induced by PHA and IL-1? were(3.6?1.1)%,(20.9?4.8)%,(17.7?8.2) ng/L,respectively.There were significant differences in HIE group and normal controls(P0.05).Conclusions There is obvious inflammatory(rea)ction in babies with HIE.The main character of PBMC of newborns is all infantile and undifferentiated,which surface sign is infantile,and lower level of CD_(25) is expressed.However,the level of CD_(25) mRNA can be expressed consistently during the course of disease.The immunity and immune regulative response in newborns is gradually built up during the growth and can participate in recondition of brain injury caused by HIE.

BACKGROUND:White spot lesions caused by enamel demineralization are a common side effect of orthodontic treatment. Resin infiltration treatment for white spot lesions has obtained favorable effects, but there is no report on the difference between resin infiltration and fluoride varnish treatment for post-orthodontic white spot lesions. OBJECTIVE:To compare the efficiency of resin infiltration and fluride varnish for treatment of post-orthodontic white spot lesions. METHODS:Twenty-nine patients with post-orthodontic white spot lesions were randomly divided into two groups:one group accepted the resin infiltration treatment and the other group accepted fluoride varnish treatment. Frontal intraoral photos before treatment and 6 months after treatment were col ected for study. The difference in efficiency of resin infiltration and fluride varnish for treatment of post-orthodontic white spot lesion was analyzed and evaluated by both dentists and College students who were not engaged in oral medicine. RESULTS AND CONCLUSION:Except one patient treated with fluride varnish, al the patients completed the referral on schedule. There was significant improvement in the two groups after treatment (P<0.05). Resin infiltration treatment was better than fluoride varnish treatment in post-orthodontic white spot lesions. Thus, resin infiltration that requires fewer referrals and has better effects is an ideal therapy for post-orthodontic white spot lesions.

Rho(Ras homologue) family play an import ant role in intracellular signal-transduction pathways. Not until recently have they been found to overexpress in many kinds of tumors such as testicular germ cell tumor,colorectal tumor,breast cancer,ductal adenocarcinoma of the pancreas and prostate cancer and been linked to the tumorigenesis and metastasis. So the members of the Rho family of small guanosine triphosphatases would be new marker s for tumor diagnosis、new markers for the prediction of metastatic potential an d new important prognostic factors. Moreover,they have the potential as therape utic targets for the prevention of cancer invasion and metastasis. In this artic le, we review the recent progress in this field.

Objective To observe the clinical results of free dorsal forearm mini-osteo-cutaneous flap to repair the bone and soft tissue defect of finger. Methods The mini-osteo-cutaneous flap pedicled on the osteo-cutaneous branch of dorsal branch of anterior interosseous artery was designed on the radial side of the distal dorsal forearm along the connective line between the Lister's tubercle and the lateral epicondyle of the humerus, the point of the cutaneous branch of dorsal branch of anterior interosseous artery entry the skin was about 3.5 cm proximal to the Lister's tubercle. The dimensions of the osteo-cutaneous-flap were planned according to the defect of recipient. The incision begins along the ulnar board of the flap and the septum between the extensor pollicis brevis muscle and the extensor pollicis longus muscle was exposed, the osteo-cutaneous branch of dorsal branch of anterior interosseous artery was indentified, then the cutaneous flap and osteo-flap was raised respectively, the osteo-cutaneous branch was dissected deeply to the origin and sectioned, the donor site was closed directly. The vascular pedicle of the osteo-cutaneous flap was anastomosed with the digital artery and dorsal vein respectively. From Jul. 1999 to Jan. 2005, 7 fingers of 7 males suffered bone and soft tissue defect with the average of 25 years old ranging from 18 to 37 years old were performed. Results All the 7 free mini-osteo-cutaneous flaps were survived completely, the dimensions of the cutaneous-flap and osteo-flap were 2.5 cm ? 3.0 cm to 4.5 cm ? 3.5 cm, 2.5 cm ? 1.0 cm to 3.5 cm ? 1.2 cm respectively. The osteo-flap was united with recipient bone 2 to 3 months after the transplantation and the donor site was closed by direct suture without tension, the appearance of the reconstructed finger by mini-osteo-cutaneous flap was perfect. Conclusion The free dorsal forearm mini-osteo-cutaneous flap pedicled on the osteo-cutaneous branch of dorsal branch of anterior interosseous artery was one of the optimal flap to reconstruct bone and soft tissue defect of the finger.

Objective To study the relationship between the mutation of androgen receptor(AR) gene and the development of human prostat e cancer. Methods All exons of AR gene except trineucl eic acid repeat polymorphism were amplified by PCR and selected by single strand conformation polymorphism( SSCP) in 27 paraffin-embedded slides of human pros tate cancer. The abnormal mobility shifts were further detected by direct DNA c ycle sequencing. Results Three abnormal mobility shifts respectively in exon A.D.G were found by SSCP in three prostate cance r tissues. One point mutation was found in 296 amino acid (C 966→A,Ser29 6Arg) from exon A.This point mutation has not been reported before. Conclusions This mutation might change the transcriptive activity of AR, and it might be correlated to PCa progression.

Objective To investigate the MRI features and the diagnostic value of uterine leiomyoma.Methods All cases were examinated by MRI and ultrasound.Retrospective analysis of MRI manifestations of 71 uterine leiomyomas in 32 patients in combination with the results of operation and pathology was carried out and was compared with ultrasound findings.Results The MRI features of the tumors were:intermediate or slightly low signal intensity on T 1WI and low signal intensity on T 2WI,patch hyperintense areas were seen in degenerated leiomyoma on T 2WI,there were clear margins in all tumors and capsules in most tumors(55/71).MRI was superior to sonography in showing 

Acupuncture Therapy ; Adolescent ; Adult ; Aged ; Chronic Disease ; therapy ; Female ; Humans ; Male ; Middle Aged ; Pterygopalatine Fossa ; innervation ; Rhinitis ; physiopathology ; therapy ; Smell ; Treatment Outcome ; Young Adult

Objective To investigate the influence of Simiao pill intervention on the life quality of patients with chronic pelvic inflammatory disease( CPID) . Methods Eighty-five cases of damp heat and blood stasis type of CPID were randomly divided into two groups:the treatment group( n=43) was treated with Simiao pill decoction combined with other Chinese herbs;the control group(n=42)was treated with Fuke Qianjin capsules.Three months after the treatment, clinical efficacy was evaluated and life quality was assessed by WHOQOL-BREF. Results The total effective rate was 90. 70% in the treatment group and 71.43% in the control group(P<0.05).Before the treatment, score of each dimension of WHOQOL-BREF in both groups was not significantly different(P>0.05).After the treatment, score of each dimension of WHOQOL-BREF in both groups were increased, and the total score was(104.21±6.67)in the treatment group and(89.60±7.31)in the control group(P<0.05). Conclusion Simiao pill decoction combined with other Chinese herbs can effectively treat damp heat and blood stasis type of CPID and improve the life quality of the patients.