A 61-year-old gentleman presented with small bowel intussusception from small bowel melanoma intussusceptum. He complains of intermittent abdominal distension but no history of intestinal obstruction. Apart from this, he was also symptomatic anemia which required repeated transfusion for the past few months. The contrast-enhanced computed tomography of the abdomen shows an omental mass with small bowel intussusception. He then underwent an exploratory laparotomy with segmental resection of the affected segment. Histopathological examination confirmed primary gastrointestinal melanoma. Multiple small bowel malignant melanoma is a rare disease. It remains a controversial diagnosis as it may be a primary or metastasis from an unidentified or regressed primary cutaneous melanoma. Prompt surgical intervention enables us to obtain tissue diagnosis, prevent complete intestinal obstruction and strategize the goals of treatment for the patient.

Department of Immunology; Institute of Basic Medical Science, CAMS and PUMC, Beijing 100005, China) Objective To study the mechanism of neuroimmunoregulation which is triggered by enhancing immunologic function via Hou Hai acupoint antigen injection. Methods Immunohistochemical method, immunofluorometric method and RT-PCR were used to examine the different distribution of cy tokine immunopositive cells in the brain and expression of cytokines in the spleen of the human IgG sensitized rats recieved acupoint, subcutaneous and normal rats antigen injections. Results In the areas of lateral hypothalamic nucleus (LH) and amygdaloid nuclear complex(AA) , the distribution of cytokines immunopositive cells with acupoint injection group was significantly increased more than that in the subcutaneous injection group. But the expression of cytokines immunopositive cells both by the acu point injection and the subcutaneous injection groups reached their peak value in similar time. Dou ble-labelling results showed that the cytokine immunopositive cells were neurons. In the spleens, the expressions of cytokines, IL-2 and IFN, were significantly increased by acupoint injection more than subcutaneous injection. Conclusions The time course of neuroimmunoregulation is similar in the im munized rats via both acupoint injection and subcutaneous injection of antigens. But the activity of neuroimmunoregulation is not the same in acupoint and subcutaneous injection groups. Neurons of the LH and AA are main source spf teh neruroimunomodulation The effect of enhancing immunlolgic funivtion via Hou acupoin injection is may be more efficent to mobnilize the activity of neitoimmunreguation of immune-asociated brain than moduation the immune system