Object To optimize the best technical parameters through controlling the different factors. Methods Taking spherical degree and pill weight as index, the above factors were observed by orthogonal test. Results PEG4000 as matrix, methyl silicon oil as refrigerant. Internal and external diameter of burette are 4 1 mm and 6 1 mm, dropping into the refrigerant that composed of 40 ℃—50 ℃,10 ℃—30 ℃,0 ℃—4 ℃ by 20 ℃—30 ℃ droppings per minute. Conclusion The highest finished product with good quality can be got through this process.

Objective: To establish an HPLC method for the determination of diclofenac sodium sustained-release preparations, and compare the in vitro dissolution of diclofenac sodium sustained-release capsules and tablets from different manufacturers to provide reference for the clinical reasonable medication. Methods: According to the first dissolution method described in Chinese Pharmaco-poeia (2010 edition),the dissolution of each sample was determined by HPLC and the cumulative release percentage was calculated. The dissolution parameters were fitted by Weibull-equation and the results were analyzed. Results:The HPLC method for the determi-nation of diclofenac sodium release was accurate with good reproducibility, and the dissolution parameters of different manufacturers had remarkable difference. Conclusion:The in vitro dissolution of diclofenac sodium sustained-release capsules and tablets from different manufacturers is various, which should be paid attention in the clinical use.

Objective To investigate the status of TCM development in Chongqing city,and to put forward countermeasures and suggestions of the development of Chinese medicine in view of the existing problems,so as to provide reference for the government and relevant departments.Methods The relevant questionnaires were issued and recycled in 20 districts and counties of Chongqing city.Part of the data culled from Chinese management office yearbooks of Chongqing.Finally,comprehensive analysis was per-formed.Results There′s enormous upside potential for the development of Chongqing traditional Chinese medicine (TCM),but there were some problems and deficiencies.The main problems were as follows:the TCM characteristics not brought into full play in traditional Chinese Medicine hospitals,lack of following talents,unsound organization management of traditional Chinese medi-cine,the government′s insufficient investment and attention for traditional Chinese medicine (hospitals,schools,“hand-to-hand”ap-proach),not enough national policy support for TCM,TCM hospitals and folk medicines of ethnic minorities,and insufficient exca-vation in ethnic minority medicine.Conclusion In order to adapt to the development of Chinese medicine and to meet the growing requirements of Chinese medicine,some countermeasures should be taken as follows:giving full play to the characteristics of tradi-tional Chinese medicine,strengthening personnel training in Chinese medicine,reforming the management mechanism,increasing the government investment,strengthening policy support for Chinese medicine and folk medicines of ethnic minorities,accelerating the process of TCM standardization,scientific and internationalization.It is suggested that the miscellaneous diseases &incurable dis-ease medicine research office and slow disease traditional Chinese medicine health care office should be established under the TCM management office.Specialized agencies are advised to mine and collect herbal remedies,recipes in ethnic minority area and so on.

Objective To explore the relationship between chronic tonsillitis and allergic purpura.Methods Fifty-six allergic purpura children with chronic tonsillitis were selected,26 children were given tonsillectomy (operation group),and 30 children were not given tonsillectomy (no-operation group).The duration of abdominal pain,duration of erythra,proteinuria negative time,hematuria negative time,antistreptolycin O rite,complement C3 were compared between the 2 groups,and the 24 h urine protein quantitarion and urine red blood cell count in operation group were compared between preoperative and postoperative.Results The duration of erythra,duration of abdominal pain,proteinuria negative time,hematuria negative time in operation group were significantly better than those in no-operation group [(10.58 ±4.22) d vs.(16.70 ±9.68) d,(6.49 ±2.45) d vs.(9.20 ± 2.21) d,(12.3 ±4.1) d vs.(16.5 ± 5.6) d,(10.1 ± 3.3) d vs.(12.7 ± 4.9) d],there were statistical differences (P ＜ 0.01 or ＜ 0.05).There were no statistical differences in antistreptolycin O tite and complement C3 between the 2 groups (P＞ 0.05).In operation group,the 24 h urine protein quantitation and urine red blood cell count postoperative were significantly better than preoperative [(0.72 ± 0.28) g vs.(1.61 ± 1.22) g,(14.95 ± 4.76) / μ l vs.(56.61 ± 12.57)/μ 1],there were statistical differences (P＜ 0.01).Conclusion Chronic tonsillitis is one of the important factors which can make allergic purpura erythra relapses and induce purpura nephritis,and tonsillectomy is the optional means of treatment of purpura nephritis with chronic tonsillitis and erythra relapses.

0.05); there was a significant difference between the groups, in which the thickness of tumor was less than 5 mm, and the other one, in which the thickness was greater than 5 mm (P

Dyslipidemia is a risk factor for stroke, and reducing low-density lipoprotein cholesterol (LDL-C) levels can decrease the risk of ischemic stroke. Both statins and PCSK9 inhibitors can effectively reduce LDL-C levels, but some patients cannot tolerate statins, and PCSK9 inhibitors are expensive. Animal experiments have shown that ezetimibe can reduce oxidative stress and endoplasmic reticulum stress response, inhibit cell apoptosis, increase autophagy, and protect nerve tissue by activating AMP activated protein kinase (AMPK) signaling pathway. Clinical studies have shown that ezetimibe can further reduce LDL-C levels on the basis of statin therapy, and reduce the risk of ischemic stroke in patients with acute coronary syndromes, and there is no obvious adverse reaction. However, ezetimibe cannot reduce the incidence of stroke in elderly people who are ≥75 years old, have elevated LDL-C and do not have coronary heart disease. At present, there are few studies on the use of ezetimibe for secondary prevention of ischemic stroke, and its effect needs to be further confirmed by large randomized controlled trials.

Objective To study the characteritics of the species distribution, vancomycin resistance phenotypes, and genotypes in Enterococci in Shenzhen Second People,s Hospital. Methods Screening vancomycin-resistant Enterococci (VRE) with agar screen, and detecting the phenotypes and genotypes of vancomycin resistance or intermediate enterococci with E test and multiple PCR-restriction fragment length polymorphism. Results Among 310 Enterococcus spp strains isolated f rom clinical samples, 235 strains (75.8 %) were Enterococcus faecalis, 71 strains (22.9 %)were E. f aecium, 3 strains (1.0%) were Enterococcus gallinarum, and 1 strains (0.3%) was Enterococcus casseliflavus. 7 strains were vancomycin-resistant or intermediate to Enterococci, vanA for 2 strains were detected, vanC1 for 3 strains were detected, vanC2/3 for 1 strains was detected, 1 strains was unknown. Their phenotypes confirmed to the genotypes. Conclusion 2 strains vanA were found. It is important for clinical laboratory to detect VRE with right methods to instruct rational application of antibiotics clinically and prevent VRE prevalence.

Acute Coronary Syndrome ; metabolism ; pathology ; physiopathology ; Cholesterol ; metabolism ; Erythrocyte Membrane ; metabolism ; Humans

OBJECTIVETo observe the clinical effect of Lingtong Capsule (LC) in treating primary dysmenorrhea (PD).

METHODSTotally 59 PD patients took LC, while 59 patients in the placebo group took placebo capsule, two pills immediately when they felt dysmenorrhea. Their pain levels were quantitatively classified. The pain score was assessed at an interval of 30 min using visual analogue scale/score (VAS) while taking medicine and within two h after taking medicine. It was assessed as effective when the pain level was reduced by more than or equal to 50% within 2 h.

RESULTSThe total effective rate was 69.49% (41/ 59) in the LC group and 20.34% (12/59) in the placebo group (P < 0.01). The analgesia effect was obviously superior in the LC group 60 min after taking medicine (P < 0.01). LC showed better effect in treating mild, moderate, and severe PD (P < 0.05).

CONCLUSIONLC showed obvious analgesia effect on PD.

Adult ; Analgesics ; therapeutic use ; Double-Blind Method ; Drugs, Chinese Herbal ; therapeutic use ; Dysmenorrhea ; drug therapy ; Female ; Humans ; Phytotherapy ; Visual Analog Scale ; Young Adult