1.Enlightenment of drug application and evaluation procedures of medicines registered (listed) in Australia on studies of new traditional Chinese medicines.
China Journal of Chinese Materia Medica 2014;39(21):4265-4267
Modern and international studies on new traditional Chinese medicines are the main trend of the development of traditional Chinese medicines at present. In Australia, new traditional Chinese medicines refer to complementary medicines, which are mainly registered and launched as listed medicines. The application documents of registered (listed) medicines in Australia mainly cover detailed description of active pharmaceutical ingredients, pharmacological and toxicological studies, dosage form and adverse effects. Each part has detailed specifications and instructions, which helps ensure that applicants could accurately understand the requirements in application for registering (listing) medicines, and provides very important reference to the studies and development of new traditional Chinese medicines in China.
Australia
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Drug Approval
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Drug Evaluation
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Medicine, Chinese Traditional
2.Advances in chemical constituents and bioactivity of Salvia genus.
China Journal of Chinese Materia Medica 2015;40(11):2096-2105
The genus Salvia in the family Lamiaceae with nearly 1 000 species, is widespread in temperate and tropical regions around the world. Many species of genus Salvia are important medicinal plants with a long history of which Danshen (the dried roots and rhizomes of S. miltiorrhiza) is one of the most popular herbal traditional medicines in Asian countries. The chemical constituents from Salvia plants mainly contain sesquiterpenoids, diterpenoids, triterpenoids, steroids and polyphenols etc, which exhibit antibacterial, antidermatophytic, antioxidant, anti-inflammatory, antineoplastic, antiplatelet aggregation activities and so on. In this article, the development of new constituents and their biological activities of Salvia genus in the past five years were reviewed and summarized for its further development and utilization.
Diterpenes
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isolation & purification
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Plant Extracts
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pharmacology
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Salvia
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chemistry
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Sesquiterpenes
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isolation & purification
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Triterpenes
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isolation & purification
3.A case of Rabson-Mendenhall syndrome.
Li MA ; Jian WANG ; Yuan-xun FANG
Chinese Journal of Pediatrics 2013;51(7):545-547
Acanthosis Nigricans
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diagnosis
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genetics
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pathology
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Adolescent
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Antigens, CD
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genetics
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Biomarkers
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blood
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DNA Mutational Analysis
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Donohue Syndrome
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diagnosis
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genetics
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pathology
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Humans
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Insulin Resistance
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genetics
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Male
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Mutation
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genetics
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Polymerase Chain Reaction
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Receptor, Insulin
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genetics
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Sequence Analysis, DNA
4.Drug design ideas and methods of Chinese herb prescriptions.
China Journal of Chinese Materia Medica 2015;40(17):3413-3415
The new drug of Chinese herbal prescription, which is the best carrier for the syndrome differentiation and treatment of Chinese medicine and is the main form of the new drug research and development, plays a very important role in the new drug research and development. Although there are many sources of the prescriptions, whether it can become a new drug, the necessity, rationality and science of the prescriptions are the key to develop the new drug. In this article, aiming at the key issues in prescriptions design, the source, classification, composition design of new drug of Chinese herbal prescriptions are discussed, and provide a useful reference for research and development of new drugs.
Drug Design
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Drug Prescriptions
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Drug Therapy, Combination
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Drugs, Chinese Herbal
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administration & dosage
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chemistry
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Humans
5.Selectively segmental cervical decompression through anterior approach:effect on the treatment of senile segmental cervical spondylotic myelopathy
Jian SHI ; Xun TANG ; Tianhua ZHOU
Orthopedic Journal of China 2006;0(09):-
[Objective]To investigate the effect of selectively segmental cervical decompression through anterior approach in the treatment of senile segmental cervical spondylotic myelopathy. [Methods]Twenty-seven cases of senile segmental cervical spondylotic myelopathy experienced selectively segmental cervical decompression through anterior approach from 2004 to 2008 were reviewed retrospectively. Pre-and post-operative JOA scores were compared to evaluate the improvement of neurological function.[Results]Patients were followed up for an average of 19.7 months (ranged,18~27 months). No loosening or displacement was found in all cases. Postoperatively,ratio of JOA improvement was 56.1%,including excellent result in 8 cases (29.5%),good result in 11 cases (40.7%),fair result in 6 cases (22.2%),poor result in 2 cases (7.4%).[Conclusion]Selectively segmental cervical decompression through anterior approach is effective in the treatment of senile segmental cervical spondylotic myelopathy,giving consideration to patient's general physical condition and recovery of neurological function. Correct segments selection of preoperative decompression is the key point of result of postoperative restoration.
6. Survey on the prevalence of chronic diseases and the demands of pharmaceutical care in elderly population in china
Chinese Pharmaceutical Journal 2016;51(2):155-158
OBJECTIVE: To understand the prevalence of chronic diseases and the demands of pharmaceutical care in the ederly, and to explore the content and mode of pharmaceutical care for elderly people. METHODS: A questionnaire survey was conducted in 1262 people over 60 years old, and the data were processed by SPSS. RESULTS: Respondents' prevalence rate of chronic diseases was as high as 95.2%, the top three chronic diseases was hypertension, bone hyperplasia/osteoporosis and coronary heart disease. The respondents' cognition and evaluation of pharmacists and pharmaceutical care needed to be improved, their pharmaceutical care needs mainly concentrated in the popularization education of medication particularity, the detailed explanation of drug instructions and the coping measures to common adverse drug reactions; lectures, face-to-face communication, pamphlets were more acceptable for the elderly to carry out pharmaceutical care. CONCLUSION: The health status of the elderly is not optimistic, and they generally have an urgent need for pharmaceutical care. Pharmacists should improve their ability, to carry out various pharmaceutical care to meet the needs of the elderly.
7.Application of SP and OSCE in the Clinical Skill Evaluation to Medical Students
Xun LIN ; Jian JIANG ; Jing ZHOU
Journal of Zhejiang Chinese Medical University 2006;0(05):-
In the clinical skill evaluation,SP and the new technology OSCE for medical educational evaluation brought by SP can offer a vivid and complete exam atmosphere for the medical students,which have been widely applied by medical colleges and schools at home and abroad,with real,effective,reliable characteristics and broader development prospect. To induce the technology into TCM clinical evaluation is in accordance with the requirements of TCM educational development,which can make students better grasp clinical various basic skills within limited studying periods.
8.Discussion on Etiology and Pathogenesis of Rheumatoid Arthritis from the Theory of Fuxie
Jian WANG ; Xun GONG ; Quan JIANG
Journal of Zhejiang Chinese Medical University 2017;41(9):719-723
[Objective] To explore the etiology and pathogenesis of rheumatoid arthritis from the perspective of the theory of Fuxie, so as to more comprehensively understand the rheumatoid arthritis, broaden the thinking of clinical diagnosis and treatment, and improve the clinical efficacy. [Methods] The theory of Fuxie theory was summarized, from the aspects of interpretation, theoretical origin, modern medical knowledge and so on, combined with the regularity of the pathogenesis of the pathogen, the etiology, pathogenesis and treatment of rheumatoid arthritis were discussed. [Results] Fuxie theory is originally derived from Huangdi Neijing, it is considered that Fuxie is divided into exogenous and endogenous Fuxie foxier, etiology of rheumatoid arthritis with hidden pathogenic objective basis, its pathogenesis with hidden pathogenic mechanism, the treatment principle and treatment method by pathogen consistentcy. [Conclusion] Understanding of rheumatoid arthritis, according to the characteristics and development of Fuxie disease transmission rules, can better grasp the nature of the disease, diagnosis and treatment of Fuxie theory of rheumatoid arthritis has important clinical significance, rheumatoid arthritis from Fuxie theory provides new ideas and methods for clinical treatment.
9.Experimental study on pathogenetic evolvement regularity of phlegm, toxin and blood-stasis syndromes in Chinese miniswine with phlegm-stasis cementation syndrome of coronary heart disease.
Jian-Xun LIU ; Cheng-Ren LIN ; Jian-Xun REN ; Lei LI ; Jun-Guo REN ; Jian-Hua FU ; Guang-Yu LIU
China Journal of Chinese Materia Medica 2013;38(23):4138-4143
OBJECTIVETo discuss that pathogenesis evolvement regularity of Chinese miniature swine with phlege-stasis cementation syndrome of coronary heart disease.
METHODEighteen Chinese miniature swine were randomly divided to the normal control group, the model group and the Danlou tablet group, with six swine in each group. Except for the normal control group, all of the other groups were fed with high fat diet for two weeks. The coronary heart disease model with phlegm-stasis cementation syndrome was established by injuring left anterior descending artery with interventional balloons and continuously feeding with high fat diet for eight weeks. The levels of BMI, hemorheological parameters, lipids in serum and inflammatory cytokines were observed at the 0th (before the experiment), 2nd (before operation or drug administration), 6th (four weeks after drug administration) and 10th week (eight weeks after drug administration) of study. The levels of TG and TC in liver and the pathological changes in coronary artery tissues were also observed at the end of study.
RESULTCompared with the normal control group, the model group had showed significant increase in the levels of TC, TG, LDL-C and VLDL-C in serum (P < 0.01) from the second week to the end of the experiment, with notable rise in the whole blood viscosity under the shear rates of 5 s(-1) and 60 s(-1). At the 6th week, the levels of BMI and TG and TNF-alpha in serum significantly increased. At the 10th week, the levels of BMI and hs-CRP, IL-6 and TNF-alpha in serum significantly increased as well, with remarkable increase in coronary stenosis, intimal thickness and the ratio between intimal thickness and media thickness (P < 0.05 and P < 0.01), and significant rise in TC and TG in livers (P < 0.01). Compared with the model group, the Danlou tablet group showed obvious reduction in severity of coronary artery lesion, intimal thickness and lumen stenosis ratio and ratio between intimal thickness and media thickness (P < 0.01), BMI, TC, TG, LDL-C and VLDL-C in serum, TC and TG in liver, as well as hs-CRP, IL-6 and TNF-alpha levels in serum (P < 0.05 and P < 0.01), with notable decline in the whole blood viscosity under the shear rates of 5 s(-1) and 60 s(-1).
CONCLUSIONThe interaction of phlegm, blood stasis and toxin syndromes helps promote the progress and development of AS plaques, which is the key pathogenesis of phlegm-stasis cementation syndrome in coronary heart disease.
Animals ; Body Weight ; Coronary Disease ; blood ; physiopathology ; Female ; Hemodynamics ; Inflammation Mediators ; metabolism ; Lipids ; blood ; Liver ; metabolism ; Male ; Medicine, Chinese Traditional ; Swine ; Swine, Miniature
10.Study on material base of corydalis rhizoma.
Xin-Bao YANG ; Xiu-Wei YANG ; Jian-Xun LIU
China Journal of Chinese Materia Medica 2014;39(1):20-27
Corydalis Rhizoma, the dried tuber of Corydalis yanhusuo (Papaveraceae) distributed traditionally mainly in south-eastern and now cultivated in northwestern and other district in China, is one of the commonly used and well-known traditional Chinese medicine. It has been widely used to treat spastic pain, abdominal pain, pain due to injury, and promote blood circulation. Its main chemical constituents were alkaloids, which were divided into the two types of protoberberines and aporphines. Among them, some alkaloids were found to elicit profound effects on the dopaminergic system in the central nervous system, which plays an important role in regulating nociception. In this article, the chemical composition and structure-types, new methods of qualitative and quantitative analysis as well as characteristics of biotransformation, absorption, distribution, metabolism, excretion, pharmacokinetic, and drug-drug interaction for the alkaloids were revealed. These results would greatly contribute to the establishment of bioactive material base of Corydalis Rhizoma.
Alkaloids
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chemistry
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Animals
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Corydalis
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chemistry
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Drug Interactions
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Drugs, Chinese Herbal
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chemistry
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metabolism
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pharmacokinetics
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Humans
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Medicine, Chinese Traditional
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methods
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Papaveraceae
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chemistry
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Rats
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Rhizome
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chemistry