On the development of Model Curricula of Pharmacology,Pharmacology Teaching and Research Department,Heze Medical College has established a framework of 5-2-3. Based the new teaching mode,the teaching methods have been improved and the traditional examination formula reformed and pharmacological experiments renewed. All of these improved teaching,experimental and testing methods are very popular with students,which has brought about satisfactory teaching effects.

Deep vein thrombosis (DVT) is a serious complication of fractures. The incidence of ankle fracture which occurs most frequently intra-articular is 200/100 000, about 3.9%of all fractures. Domestic and foreign reports of ankle fractures and DVT were allocated and analyzed to review their correlation. Furthermore, different methods of rou-tined thromboprophylaxis was discussed. DVT incident after ankle fractures and the necessity of routined thromboprophy-laxis were reviewed. DVT incidence after ankle fractures was low and routine thromboprophylaxis was not necessary to all ankle fracture patients except the ones who had risk factors of thrombosis which could induce DVT.

As the passage of environmental atmosphere entering the body,the respiratory tract suffers persistent challenge from foreign substances.The mucosal immune system of the respiratory tract is the main defense line against the invasion of pathogens,which needs to distinguish not only beneficial and detrimental materials but also resident and pathogenic bacteria.Because the knowledge about respiratory mucosal immunity is limited,the immunopathologic mechanisms of related diseases such as asthma,acute lung injury, chronic obstructive pulmonary disease, and respiratory infection need investigation.The study about the immune features of the respiratory tract not only contributes to the prevention and treatment of respiratory disease but also provides ideas for the development and design of new vaccines and medicines.

OBJECTIVE:To study the anti-hepatofibrotic action of 18?-glycyrrhizic acid(18?-GL) and gamma interferon (IFN-?) in rats METHODS:The rat model of liver fibrosis was induced by dimethyl nitrosamine(DMN),18?-GL or IFN-? was administrated before and 5 weeks after giving DMN,to prevent and treat liver fibrosis The pathological changes and degree of fibrosis in the liver were observed and compared with that of DMN control group RESUTLS:Compared to DMN control group,the collagen deposition in both 18?-GL and INF-? groups was significantly slight in degree(P

OBJECTIVE:To investigate the application of vancomycin in pediatric patients.METHODS:By reviewing medical histories of 368 pediatric patients who had been treated with vancomycin from 2005 to 2006,the use of vancomycin was investigated in respect of children' general condition,microbiological examination,dosage regimen,adverse drug reactions to evaluate the rationality of drug use.RESULTS:ADR occurred in 17 cases(4.6%).The use of vancomycin was rational or basically rational in 240 cases(65.2%).CONCLUSION:It is necessary to tighten more strict control on the use of vancomycin in pediatric patients.

OBJECTIVE:To determine the content of hydroxyproline in liver tissue in rats with hepatic fibrosis.METHO_ DS:RP-HPLC was used with precolumn derivation by2,4-dinitrochlorobenzene(DNCB)in the Borax buffer solution for lh in boiling water.Acetonitrile-acetate buffer linear gradient elution was used.Detecting wavelength was360nm.RESULTS:Derivation of hydroxyproline could be separated from other amino acids and accurately determined.CONCLUSION:The method is rapid,accurate,and suitable for detection of biopsy samples obtained by liver puncture.

Endogenous NO and CO have been identified in the recent years as signaling molecules and act as the messengers in the body . Both of them have identical characteristics in the mechanism of production and action. Many evidences indicated that NO and CO play important roles in physiological and pathophysiological processes in the prostate. This review highlights the current ideas on localization and function of them in the prostate. We also discussed the relationship between the gaseous messengers and the prostatic diseases.

In 2010, Chinese Pharmacopoeia Committee officially enacted Chinese Pharmacopoeia (2010 edition). The Volume 1 of the pharmacopoeia is comprised of the medicinal materials and the decoction pieces, the essential oils and extracts of medicinal plants, prescription preparations and single preparation, etc., which not only provides Latin names of Chinese medicinal materials, also provided Latin names of the original medicinal plants to effectively control the quality of Chinese medicinal materials. In order to raise awareness of correctly citation and maintain the authority and standardization of Chinese Pharmacopoeia, this paper briefly describes abbreviations rules of authors' name of plant scientific name according to the 'International Code of Botanical Nomenclature, ICBN'. Through comparing with the rules of ICBN, 'Flora of China' (Chinese edition and English edition), and authority international plant catalogue databases, the authors made statistic and analysis of the non-standard cited authors' names phenomena of the original plant scientific names recorded in the Chinese Pharmacopoeia (2010 edition), and the revision suggestions are proposed.
Asian Continental Ancestry Group ; Authorship ; China ; Databases, Factual ; Drugs, Chinese Herbal ; classification ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; methods ; Pharmacopoeias as Topic ; standards ; Plants, Medicinal ; chemistry ; classification ; Reference Standards ; Terminology as Topic

Objective: To design and prepare HBc virus-like particle vaccine (VLP) harboring the specified epitope of gastric inhibitory peptide (GIP), and to study its immune effects, so as to cast new lights on immune therapy of obesity. Methods: GIP cDNA was cloned and was fused with HBc VLP (1-144aa) cDNA. Through prokaryotic expression and purification processes, a GIP vaccine linked to the HBc-derived VLP carrier was constructed. We also cloned the fusion gene into eukaryotic vector pVAX1 to prepare GIP nuclear acid vaccine. And the two kinds of vaccines were tested in rats for their immunological parameters. Results: GIP vaccine linked to HBc-derived VLP carrier was successfully prepared. We also prepared the genetic vaccine pVAX1-HBc-GIP. The combined vaccination with both vaccines could obtain high titer and peptide-specific IgG antibody, displaying a satisfactory immunogenicity. Conclusion: GIP protein vaccine using HBc as immune-enhancing vaccine carrier can effectively induce GIP-specific humoral immunity, disrupting the tolerance to self antigens in rats. The vaccine is worth studying as a new drug for control of obesity.

In response to problems from the development of multi-drug-resistant pathogenic bacteria,it is urgent to find new antimicrobials.Antimicrobial peptides(AMPs) are a kind of ideal new antimicrobials with the advantages including their potential for broad-spectrum activity,rapid bactericidal activity and low propensity for resistance development,and have a bright future.Alpha-helical antimicrobial peptides are a main kind of AMPs.The following features was reviewed and elucidated including the structure and activity relationship(SAR) from different aspects including the degree of helicity,hydrophobic moment,hydrophobicity,net positive charges and so on,and the application of SAR on the molecular design and improvement of AMPs.