Crohn Disease ; epidemiology ; surgery ; Humans

Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

To augment the levels of diagnosis and treatment for colorectal cancer and make them standardization in China, the Ministry of Health of the People's Republic of China released Chinese Standard for The Management of Colorectal Cancer (2010) in November 4, 2010. This standard incorporates the most recent progresses in colorectal cancer, and it provides standard guidelines with respect to diagnosis, pathologic examination, surgery, adjuvant therapy in the management of colorectal cancer in China.
China ; Colorectal Neoplasms ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

Humans ; Neoplasm Recurrence, Local ; prevention & control ; Rectal Neoplasms ; pathology

Colorectal cancer has become one of the most common malignant tumors that affects Chinese's health. Recurrence and metastasis are main reasons for death of colorectal cancer patients. Making up individualized and comprehensive therapeutic strategy according to patients' specific matters is the developmental direction of diagnosis and treatment for colorectal cancer. Only if standardize clinical pathway, perfect postoperative follow-up system, and accelerate research development on biomarkers, individualized therapy of colorectal cancer can be accomplished.
Colorectal Neoplasms ; diagnosis ; surgery ; therapy ; Humans ; Precision Medicine

Colectomy ; Colorectal Neoplasms ; surgery ; Humans

There is a significant gap between China and the optimal international level in terms of the treatment outcomes of colorectal cancer. In recent years, progresses have been made while limitations still exist in the management of colorectal cancer. Advances are seen including use of multi-disciplinary therapy, neoadjuvant chemoradiation, laparoscopic surgery and management of liver metastasis. Individualized therapy is also applied in colorectal cancer. However, randomized controlled trials based on Chinese population are still lacking. Radiation therapy is inadequate and standardization of surgical technique is to be improved. Although standardization of management of colorectal cancer has gained attention from the government, there is a long way to go. The establishment of subspecialty training and practice has not been satisfactory. National efforts are needed to improve the treatment outcomes of colorectal cancer in China.
China ; Colorectal Neoplasms ; therapy ; Humans ; Laparoscopy ; Liver Neoplasms ; Neoadjuvant Therapy ; Treatment Outcome

China ; epidemiology ; Humans ; Mesentery ; surgery ; Rectal Neoplasms ; epidemiology ; surgery

BACKGROUND:Lung cancer stem cel s are tightly related to the treatment and prognosis of lung cancer. We can provide more references for clinical diagnosis and treatment of lung cancer through the study on the tumorigenicity and surface markers of lung cancer stem cel s. OBJECTIVE:To explore the enrichment methods for lung cancer stem cel s and cel ular tumorigenicity. METHODS:Lung cancer stem cel s were induced in serum-free culture medium containing epidermal growth factor, insulin-like growth factor 1, and basic fibroblast growth factor. Then, the expressions of related surface markers were detected using immunofluorescence method. After that, mice were implanted subcutaneous with lung cancer stem cel spheres to understand the tumorigenicity of lung cancer stem cel s. RESULTS AND CONCLUSION:Lung cancer stem cel s under serum-free induction and culture were changed to sphere-forming cel s, and the immunofluorescence detection showed that over 80%of sphere-forming cel s were positive for CCSP, SP-C and OCT4. After transplantation of sphere-forming cel s, the mice showed a high tumorigenicity. These findings indicate that sphere-forming cel s are formed after serum-free suspension culture of lung cancer stem cel s, which have a higher tumorigenicity.

Chemotherapy, Adjuvant ; Combined Modality Therapy ; Humans ; Radiotherapy, Adjuvant ; Rectal Neoplasms ; drug therapy ; radiotherapy