0.05). The concentrations of MMP-2 and MMP-9 were significantly increased on days 1, 10, and 30 after percutaneous coronary intervention, and those on day 10 were higher than on day 1 (P

Objective To investigate the association of single nucleotide polymorphisms (SNPs) of loci rs4570625,rs11178997 at promoter region of tryptophan hydroxylase 2 (TPH2) genes with alcohol dependence and depressive symptom in the alcohol-dependent subjects in north Chinese Han people.Methods Genotype and allele frequencies of the TPH2 rs4570625 and rs1 1178997 polymorphisms were examined in 60 alcohol-dependent subjects (patient group) and 62 normal controls (control group) by Polymerase Chain Reaction (PCR) amplification and DNA sequencing techniques.The alcohol-dependent subjects were evaluated by 24 Hamilton Depression Scale (HAMD).Association analysis was carried out between the polymorphism and symptom of depression in the alcohol-dependent subjects.Results There were significantly statistical differences in the rs4570625 alleles (G and T) (x2 =5.280,P＜0.05),but no statistically significant differences in the genotypes (G/G,G/T,T/T) (x2 =5.078,P＞0.05) between patient group and control group.Significant statistically difference could be found in the rs4570625 alleles (G and T) between the alcohol-dependent subjects who had depressive symptoms and the subjects who did not have depressive symptoms (P＜0.05),but no significantly statistical differences could be found in the genotypes frequency (P＞0.05).No significant statistically differences in the genotype and allele frequencies of the rs 11178997 were observed between the alcohol-dependent subjects and normal controls and the alcohol-dependent subjects who had depressive symptoms and the subjects who did not have depressive symptoms (all P＞0.05).Conclusion The results suggest that the liability of alcohol dependence and depressive symptoms in alcohol-dependent subjects may be associated with the polymorphisms of TPH2 rs4570625 in north Chinese Han population,and the variant of the T allele may contribute to the morbidity.However,the polymorphisms of TPH2 rs1 1178997 may have no association with the susceptibility of alcohol dependence and the depressive symptoms accompanied with alcohol dependence.

Objective To investigate the changes and clinical significance of serum procalcitonin (PCT) level in children with acute phase of Kawasaki disease (KD). Methods The serum PCT levels and their changes before and after the treatment in 120 children with KD at acute phase were retrospectively analyzed. According to the results of ultrasonic echocardiography, all children were divided into coronary artery damage (CAL) group and no coronary artery lesion (NCAL) group. According to the presence of gastrointestinal symptoms, patients were divided into two groups (A: yes and B: no ). According to the presence of abnormal liver function, patients were divided into two groups (C:yes and D:no). PCT levels were compared between groups. Results The serum PCT levels were increased at acute phase in 56 (46.67%) patients before the treatment than those in normal children, which were decreased obviously after treatment (P<0.05). There were 31 cases combined with CAL, the rising rate of PCT was 38.71%, which was no significant difference compared with that of NCAL group (49.44%, P>0.05). There was no significant difference in serum PCT value between CAL group and NCAL group (P>0.05). The serum C-reactive protein level was significantly higher in CAL group than that of NCAL group. There were 35 patients combined with gastrointestinal symptoms in 120 KD patients. There was no significant difference in the rising rate of PCT between patients with gastrointestinal symptoms (62.86%) and patients without gastrointestinal symptoms (40.00%, P<0.05). There was no significant difference in serum PCT level between these two groups of patients. There were 42 cases with liver dyfunction in 120 KD patients, the PCT rising rate (52.38%) was no statistically significant difference compared with that of patients with no liver dyfunction (43.59%, P>0.05). And there was no significant difference in serum PCT value between the two groups (P>0.05). Conclusion PCT can reflect the acute phase of KD patients. The increased PCT level may be related with the emergence of gastrointestinal symptoms, even though it cannot predict CAL and the occurrence of liver damage.

The histological changes in tibial lengthening with metaphyseal osteotomy were observed in 30 goats.It was found that (1) slow lengthening rate of 1 mm/day could enable the tissues to adapt the mechanical traction,and consequently the limitation of elongation could be increased;(2) the new bone formed in the lengthened region might be the result of a combined osteogenesis from endochondral,intramembranous,and fibrous tissue ossification;and (3)the osteogenetic process could be distinguished into 3 stages of hemorrhage and organization of the hematocele,callus formaton,and remodelling of the new bones.

Objective To discuss the significance of ventricular rate for patients with persistent atrial fibrillation and to provide theoretical evidence for how to prevent patients of atrial fibrillation from complications such as cerebral embolism and left ventricular dysfunction, and so on. Methods Patients with persistent atrial fibrillation for more than 1 year were divided into cerebral embolism group and non-cerebral embolism group,30 patients per group. The data of patients in both groups were collected and compared, including general clinical characteristics, prothrombin time international standard ratio (PT-INR), the highest, lowest and average ventricular rate detected by Holter monitor system, left atria diameter and left ventricular ejecting fraction measured by echocardiography. Results There was no significant difference between two groups about general clinical characteristics, left atria diameter and PT-INR. The highest,lowest and average ventricular rate were much higher in patients of cerebral embolism group than those in non-cerebral embolism group. However, left ventricular ejecting fraction was much lower in embolism group. Conclusions It is critical to control heart rate for patients of persistent atrial fibrillation to prevent cerebral embolism and left ventricular dysfunction.

The association of polymorphisms of calcium channel?1 subunit ( Cav1.1 ) gene ( - 1551T/C at exon 11 ) with thyrotoxic periodic paralysis (TPP) was investigated by PCR-RFLP.The distributions and frequencies of - 1551TC + CC genotype and C allele in TPP group were significantly higher than those in hyperthyroidism (HT) and normal control (CON) groups.There was no statistic difference between HT and CON groups.Cavl.1 gene - 1551TC + CC genotype and allele may contribute to the development of TPP in male HAN population from North China.

Primary tracheal tumor is an uncommon disease in clinical oncology .It tends to be misdiag-nosed in very early stage ,as well as lack of standards for staging and treatment nowdays .The main strategy for the treatment of primary tracheal tumors is surgical comprehensive treatments .But as the huge development of modern radiotherapy technology the past a few years ,radiotherapy could play more and more important roles in the treat-ment of tracheal tumors.Meanwhile,the application of tracheal scaffold have provided the patients with tracheal tumors some new choices on the treatments .Yet,there are no guildline for the standard of the surgery ,the dose of the radiotherapy and the definition for the tumor target volumes .Here,we give a review on the latest process and research on the treatment of primary tracheal tumors .

A 44-year-old male complained recurrent swelling and pain in the left pre-auricular mass over 4 years, which aggravated for 4 months. Ultrasonography revealed a mixed mass echo in the left parotid gland. Computed tomography showed an enlarged parotid gland and a 1.5 cm x 0.9 cm low density shadow in the superficial lobe area with strip high-density shadow in the edge. Although the facial nerves of the patient were found adhered to the foreign body during the operation, the foreign body in parotid gland was removed surgically without any injure to them due to facial nerves protection. In conclusion, facial nerves dissection is necessary to avoid the postsurgical facial paralysis in the surgical removal of foreign bodies in parotid gland.
Adult ; Facial Nerve ; Foreign Bodies ; Humans ; Male ; Parotid Gland

Objective To investigate the distribution of vancomycin-resistant genes and virulence genes in vancomycin-resistant Enterococcus (VRE) isolates from intensive care unit (ICU).Methods A total of 180 anal swabs were collected from patients in ICU in Tianjin Medical University General Hospital during September 2012 and May 2013.VRE strains were screened by ChromID agar method.Vitek 2 Compact system was used in drug sensitivity test,and the sensitivities to vancomycin and teicoplanin were further determined using Kirby-Bauer disk diffusion method.Vancomycin resistant genes vanA,vanB,vanC1 and virulence genes esp,hyl were detected by polymerase chain reaction(PCR).Results Nineteen strains of vancomycin resistant Enterococcusfaecium were isolated from 180 anal swabs.All 19 VRE isolates were resistant to both vancomycin and teicoplanin,while they were susceptible to linezolid and tigecycline.All VRE isolates carried vanA and esp genes,and hyl gene was positive in 10 isolates.Conclusions VRE isolates from ICU are highly resistant to commonly used antibacterial agents,and most isolates carry vancomycin-resistant genes and virulence genes.Linezolid and tigecycline may be recommended for VRE infection in ICU.

Objective To compare with the characteristics of different demographic and blood donation behaviors of the first blood donors and the repeated blood donors,to analyze the related factors influencing the repeated blood donation behavior,to provide the evidence to develop the recall strategy for the retention of the first-time donors strategies.Methods Use methods such as the composition ratio of descriptive analysis,and logistic regression analysis,Retrospectively analyzed the data of 3 226 571 cases of the whole blood donors in Zhejiang province from 2006 to 2015.from BIS2.0 Results ZheJiang repeated blood donors in 2006-2015 is accounted for 30.8％,men (57.8％),the proportion of aged 25 above is higher than the first blood donors;71.7％ of men in the repeated blood donors are 60-79 kg,52.2％ of women repeated blood donors are 50 to 59 kg;40％ of the repeat donors blood for the first time donate 400 mL;71.6％ of the repeated blood donors to donate again in 0.5-2 years,and of these,40.8％ back in 0.5-1 year.Conclusion The main factors on the demographic aspects that influence the repeated blood donation is occupation,cultural degree,the quantity of blood donation for the first time.The characteristics of the precise recall people are as follows:Age 26 to 45 years old,stable career,donate 400 mL for the first-time,weight 70-89 kg of male,weight 55 kg above of women.The better recall intervention Interval is preferred to 0.5-2 years,and 0.5-1 year is the best.