Antibody drug is a new kind of new anticancer drug with distinct superiorities in tumor thera-py developed in recent years.Antibody drugs can effectively kill the tumor cells with goodselectivity,and have good efficacy,lower toxicity and a specificity of distribution in vivo.They can specifically bind to tumor-associated target moleculars.Besides,the antibody drugs can effectively kill the tumor cells with drug-resistane.

In recent years,the techniques of radical cystectomy and urinary diversion are continually improving,the surgical safety and efficacy are continually increasing.From open to laparoscopic to robotic,surgical techniques are progressing,but it is not yet possible to replace each other.With the development of equipment,laparoscopic radical cystectomy (LRC) and robotic-assisted laparoscopic radical cystectomy (RARC) can further improve the perioperative efficacy,the basic principles of open surgery can be copied,their perioperative oncologic outcomes are not inferior to open surgery.RALRC seems to have more advantages in pelvic lymph node dissection,long-term oncologic outcomes of the three techniques are simnilar,and open surgery seems to have more advantages in advanced tumors.Intracorporeal construction of the urinary diversion is still the mainstream,extracorporeal is likely to be the future direction.Laparoscopy is still the most suitable minimally invasive technique of radical cystectomy according to our national conditions.

Lysosomes are acidic catabolic organelles,containing over 50 acid hydrolases and many lysosomal specific membrane proteins.Lysosomes are responsible for the disposal and recycling of worn out and damaged cellular macromolecules and organelles as well as the digestion of extracellular and foreign materials delivered to them by endocytosis,autophagy and phagocytosis.Increased expression and function of various lysosomal hydrolases are common in human tumors,and they often correlate with a higher risk of rccurrence and poor prognosis.Inhibition of lysosomal exocytosis can inhibit tumor invasion and metastasis.It does not affect the activity of acid hydrolytic enzymes,but causes the instability of lysosomal membrane and increases the sensitivity of tumor cells to drugs.

Objective To explore the relapse prevention effect of community independent skills in patients with schizophrenia.Methods 100 patients with schizophrenia from May 2014 to February 2015 were analyzed and divided into the observation group and the control group by using the computer random grouping.The standardization of community rehabilitation training was taken in the control group patients,whike independent skill training was taken in the observation group patients.The clinical curative effect of the study for a year were evaluated through SAPS, BPRS,SDSS,SANS and ITAQ for all the object.Results There was no statistical significance of ITAQ,SDSS,SAPS and SANS score difference in all the research objects before the rehabilitation treatment has (P >0.05 ).ITAQ, SDSS,SAPS and SANS score of the observation group were better than that of the control group after 8 weeks, 26 weeks and after 1 year,the difference was statistically significant(P <0.05).Recurrence rates of the observation group and control group were 16% and 40% respectively,and hospital admission rates were 10% and 32% respec-tively,the difference was statistically significant(P <0.05).The adherence were significant between the two groups (χ2 =6.92,P <0.05).Medication adherence to drug management ability were better in the observation group than the control group(χ2 =41.558,P <0.05).Conclusion The community independent skill training have an remarka-ble effect on the rehabilitation of patients with schizophrenia,and can improve the residual symptoms of schizophrenia after rehabilitation.It can help people with schizophrenia to maintain a good long-term positive effect,which is worth further clinical research and extension.

Hand, Foot and Mouth Disease ; diagnosis ; therapy ; Health Education ; Humans

Child, Preschool ; Female ; Humans ; Infant ; Male ; Tuberculosis ; epidemiology

Bioterrorism ; classification ; psychology ; trends ; Communicable Diseases ; transmission ; Disease Transmission, Infectious ; prevention & control ; Humans

The influenza A is an acute respiratory infection persistently threatening human health and social stability, and has caused high morbidity and mortality. The development of novel anti-influenza drugs based on new targets is very significant because of high mutation and drug resistance of influenza virus. The nucleoprotein of influenza A virus identified high conservation, provides cross immune protection as a potential target of anti-influenza drugs and reports on relevant studies have been published at home and a- board. Herbal drug as a traditional Chinese medicine shows the distinct advantages in the aspect of prevention and treatment of influenza A. This paper analyzes the structure and function of influenza a virus, and reviews the advances in the research on anti-influenza targets based on the nucleoprotein of the influenza A virus.
Animals ; Drug Discovery ; methods ; Humans ; Influenza A virus ; drug effects ; metabolism ; physiology ; Influenza, Human ; drug therapy ; Molecular Targeted Therapy ; methods ; Nucleoproteins ; chemistry ; metabolism ; Virus Replication ; drug effects

Objective To investigate the effect of herbs for nourishing kidney and strengthening governor vessel on postoperative intervertebral fusion rate in elderly patients with degenerative lumbar spinal stenosis ( DLSS) . Methods A retrospective analysis was carried out for the clinical data of 72 elderly DLSS patients treated with modified transforaminal lumbar interbody fusion (TLIF) during the period from October, 2012 to October, 2013. The patients were divided into two groups, 39 in Chinese medicine group and 33 in control group. Operative efficacy was evaluated with Japanese Orthopaedic Association ( JOA) scores for assessment of cervical myelopathy, postoperative function improvement was evaluated by Oswestry disability index (ODI) scores, and lumbar interbody fusion was evaluated by the modified Brantigan scores. Results (1) During the follow-up period, patients of the two groups had no complications such as screw breaking or loosening, cage displacement, or endplate collapse. (2) Before opera tion and 3 days after operation, the differences of JOA scores were insignificant between the two groups (P>0.05) . (3) Significant difference of intragroup ODI scores were shown 12 months after operation vs 6 months after operation, and between 6 months after operation and pre-operation in the two groups (P<0.01) . ODI scores of Chinese medicine group 6 and 12 months after operation were lower than those of the control group, the difference being significant ( P<0.05 or P<0.01) . ( 4) The results of modified Brantigan scoring showed that the interbody fusion rate 6 months after operation was 71.79% in Chinese medicine group, higher than 48.48% in the control group ( P<0.05) . Twelve months months after operation, the interbody fusion rate was 87.18% in Chinese medicine group, higher than 66.67% in the control group (P<0.05) . Conclusion Herbs for nourishing kidney and strengthening governor vessel may improve the lumbar interbody fusion rate and the quality of life of the elderly DLSS patients treated by modified TLIF.