[Objective]To introduce the clinical experience of Pro.Huo Jiege treating lung cancer in the elderly. [Methods]Through copying prescription with the teacher and carding records, and studing on Chinese literature, sum up Pro.Huo Jiege ’s unique insights for the etiology, pathogenesis, principles and methods, and explains it by one case. [Results] Pro.Huo Jiege thinks that the treatment of elderly lung cancer should base on syndrome differentiation, regulate spleen and stomach and nutrition to other organs at the same time.[Conclusion]The treatment of lung cancer in the elderly patients by Traditional Chinese medicine has achieved some effect in clinical practice and provides guidance in the clinical practice.

Angioplasty, Balloon, Coronary ; Humans ; Myocardial Infarction ; therapy

Objective To investigate the effect of glutamic acid (monosodium glutamate,MSG) on Tourette's syndrome (TS). Methods These rats were divided into 2 groups: one group with acute intracerebroventricularly injection (ICV) of MSG or artificial cerebrospinal fluid (CSF), and another group with chronic administration of MSG in a dose of 40 mg/kg in drinking water everyday. Observers who were blind to the two- part subjects assessed the scores of TS- like stereotyped locomotion. Results 1. These groups of 100 ?g or 200 ?g glutamic acid may induce significant TS - like stereotyped locomotion ( P

Objective To study the distribution of brain dopamine transporter (DAT) in children with autism by single photon emission computed tomography (SPECT). Methods Brain SPECT imaging was performed in 10 autistic children and 10 normal children, and DAT distribution in different functional areas of brain were calculated and compared by semi-quantitative evaluation of tracer uptake. Results There were no differences in tracer uptake between left and right striatum either in autistic children or in normal children (P=0.556, 0.563), while the tracer uptake level in autistic children was significantly higher than that in normal children (P=0.018). Conclusions The striatum dopaminergic neurons are hyperactive in children with autism. SPECT is helpful for the diagnosis of autism.

In order to realize the seamless connection between superior and inferior medical institutions and simplify the process of patient referral to superior medical hospitals from the community medical institutions,Zhenjiang First People's Hospital designs a two-way referral platform for direct registration to Zhenjiang First People’s Hospital from community medical institutions.The paper introduces the design process,features and realization steps of this platform.The platform can realize the sharing of patient information between the community medical institutions and the hospital,facilitate patients' seeing a doctor and improve medical service level.

Objective To investigate the biological safety of silicon membrane embedded permanent magnets implanted into canine, so as to evaluate the safety of a micturition alert device designed on the principle of compass. Methods Twelve adult male dogs (weighing 11-12 kg) were divided into experimental group (8 dogs) and control group (4 dogs ). The experimental group was implanted with a silicon membrane embedded NdFeB magnet, which was 10 mm in diameter and 3 mm in thickness and with a magnetic induction intensity of 0. 3 Tesla at the center of the pole face surface. The control group was implanted with a silicon membrane embedded NdFeB alloy with the same dimensions. The grafts were sutured onto the anterior surface of the bladder wall. The dogs were then allowed to live for one year. Both the survival and local pathology around the grafts were observed after implantation. And the pre-operation urine and post-operation urine were compared between the two groups. Results One dog in the experimental group died from operation complications 10 hours after operation, another dog had intestinal obstruction 3 weeks after operation because iron wires in the intestinal tract was caught up by the permanent magnet. The rest 6 dogs in the experimental group and 4 dogs in the control group had no abnormalities in spirit, appetite, urine or stool, and there were no infections. The animals were sacrificed one year after operation. Adhension was found between the epiploon and the bladder wall around permanent magnets in these 10 dogs; the fibrous capsule around the permanent magnets was thin, and the local bladder wall below permanent magnets was thickened, with normal bladder mucosa. Grade 2 inflammatory reaction and fibrous capsule of the local tissue were noted around the grafts. The findings of urine routine were normal before and after operation. Conclusion NdFeB permanent magnets embedded with silicon membrane are biologically safe for clinical application, which warrante further investigations.

Air Pollutants, Occupational ; analysis ; Chromatography ; methods ; Sulfur Dioxide ; analysis ; Workplace

To understand the impact of salvianolate injection treatment of liver and kidney function using different from the hospital information system nationwide 18 large three hospitals (hospital information system, HIS) to extract using salvianolate age 18-80 years-old patient, a total of 10 470 cases, depending on the treatment used to have two times before and after treatment 7 d aspartate aminotransferase (AST), alanine aminotransferase patients (ALT), serum creatinine (Cr) and blood urea nitrogen (BUN) measurement indicators grouped according salvianolate continuous use different treatment patients were divided into two groups, continuous medication time > 14 d were defined as the observation group, ≤ 14 d were defined as the control group, continuous medication longer than 31 d were not included in the analysis. Each index number of the observation group and the control group were: ALT (268/1 465), AST (270/1 585), Cr (278/1 582), BUN (278/1 611). After using propensity score methods to balance two groups of covariates, based on unweighted logistic regression logistic regression propensity score weighting combined with propensity score weighting to adjust for covariates logistic regression of liver and kidney function in the two groups were analyzed. The results showed: three logistic regression analysis showed no likelihood of ALT, AST, Cr targets two groups of patients with abnormal statistically significant difference, continuous medication time > 14 d may increase the risk of abnormal BUN indicators, comprehensive analysis still can not explain use different treatment of patients salvianolate cause liver and kidney toxicity damage, still large prospective randomized controlled trials further study.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alanine Transaminase ; metabolism ; Aspartate Aminotransferases ; metabolism ; Blood Urea Nitrogen ; Creatinine ; blood ; Female ; Humans ; Injections ; Liver ; drug effects ; metabolism ; Male ; Middle Aged ; Plant Extracts ; administration & dosage ; adverse effects ; therapeutic use ; Prospective Studies ; Young Adult

Objective To establish a PCR-RFLP method for detection of CD26 mutation of hemoglobin E(HbE)gene.Methods The genome DNA from the family members who were suspected of having HbE combined with beta-thalassemia was amplified using PCR.The PCR products were digested by restriction endonuclease Mnl I,and then separated on PAGE.The electrophoretical patterns were finally analyzed to confirm if CD26 mutation was present or not.Results Four cases with CD26 mutation in two families were successfully screened out.Conclusion Although the incident frequency of CD26 mutation in Sichuan population is not high,it must not be neglected since it may present alone or combined with other type of thalassemia.PCR-RFLP method described in this study is available in screening mutated HbE gene and treating the disease owing to its simplicity,rapidity and specificity.

Objective To study B lymphocyte subsets(na(?)ve B cells,memory B cells and plas- mablasts)of peripheral blood in patients with rheumatoid arthritis(RA)and its relationship with autoantibod- ies and clinical manifestation.Methods Blood samples and clinical data of 60 patients with RA were enrolled into this study.They were divided into three groups:active,inactive and refractory RA based on clinical mani- festations and 24 healthy controls were included.CD19 and CD27 of B cells in peripheral blood of RA patients and healthy controls were detected using flow cytometry at single-cell level.Frequence of na(?)ve B cells (CD19~+CD27~-),memory B cells(CD19~+CD27~(dim)),plasmablasts(CD19~+CD27~(high))and average fluorescence in- tensity of CD19 were analyzed,and their relationship with clinical manifestations and rheumatoid factor(RF), anti-typeⅡcollagen(anti-CⅡ),anti-cyclic citrullianted peptide(CCP)antibodies were investigatied.Results Frequence of na(?)ve B cells and plasmablasts in peripheral blood of patients with RA was increased compared with normal control.In contrast,memory B cells in patients with RA were decreased.The na(?)ve B cells subset in inactive and refractory RA was higher than that of healthy controls(P＜0.05),and the memory B cells subset in those groups was lower than that of healthy controls(P＜0.05).The plasmablasts in active and refractory groups of RA were higher than those of healthy controls(P＜0.05).The average fluorescence intensity of CD19 in peripheral blood in patients with RA was positively correlated with ESR,C-reactive protein(CRP),healthy assessment questionaire(HAQ),and plasmablasts was positively correlated with arthrocele index.Na(?)ve B cells,memory B cells and plasmablasts subsets had no relation with RF,anti-CⅡand anti-CCP antibodies. Conclusion B cell subsets in peripheral blood of patients with RA are significantly abnormal,characterized by expanded naive B cells and plasmablasts but diminished memory B cells.Plasmablasts are increasesd in active and refractory groups of RA,and have positive correlation with swollen joint index.B cells may play an important rote in the pathogenesis of RA.