1. Comparative study of risk factors for early and advanced atherosclerosis
Chinese Journal of Cerebrovascular Diseases 2011;8(4):189-194
Objective: The purpose of this study is to compare the risk factors for the two different atherosclerosis processes, namely the early atherosclerosis and advanced atherosclerosis. Methods: Using magnetic resonance angiography and high-resolution B-mode ultrasonography, 92 patients with advanced atherosclerosis (atherosclerotic cerebral infarction/transient ischemic attack) and 120 patients with early atherosclerosis (no cardiovascular and cerebrovascular diseases and carotid stenosis <40% on B-mode ultrasonography) were included. The difference and similarity of the risk factors for early atherosclerosis and advanced atherosclerosis were compared respectively using the binary logistic regression. Results: In the binary logistic model of carotid plaque formation, the traditional risk factors, such as age (years) (OR, 1.101, 95% CI: 1.046-1.159, P < 0.001), high TC (OR, 2.236, 95% CI: 0.821-6.089, P = 0.0115), hypertension (OR, 2.623, 95% CI: 0.989-6.957, P = 0.053), and smoking (%) (OR, 7.975, 95% CI: 2.274-27.9651, P =0.001) were the statistically significant independent variables. In the binary logistic model of advanced atherosclerosis, male (OR, 2.064, 95% CI: 1.137-0.748, P = 0.017), high Lp (a) (OR, 2.818, 95% CI: 1.499-5.298, P=0.001), low HDL (OR, 2.451, 95%CI: 1.234-4.868, P=0.010), and diabetes mellitus (OR, 2.414, 95% CI: 1.232-4.731, P=0.010) were the statistically significant independent variables. Conclusion: The risk factors for advanced atherosclerosis and early atherosclerosis are different, diabetes mellitus and lipoprotein (a) may play an important role in the advanced atherosclerosis.
3.Serum excitatory amino acids concentrations in patients with amnestic mild cognitive impairment or Alzheimer's disease
Chinese Journal of Neurology 2005;0(08):-
Objective To figure out changes of serum excitatory amino acids (EAAs) levels in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).Methods The levels of serum EAAs was assessed in 34 cognitively normal control subjects,30 patients with aMCI,and 32 patients with AD using high performance liquid chromatography (HPLC).Results ①Higher serum concentrations of glutamate((39.6?22.1) ?mol/L),alanine((282.5?71.3) ?mol/L) were found in the aMCI patients (P=0.044,P=0.007),and higher serum concentrations of glutamate ((42.2?21.8) ?mol/L),glycine ((464.2?142.6) ?moL/L) were found in the AD patients than in the control subjects (P=0.010,P=0.010).②No statistically significant difference of EAAs level between the aMCI and AD groups was found.③A close and positive correlation between the serum concentrations of glutamate, aspartate and the mini-mental status examination scores were found in AD patients:the 2 amino acid levels were higher in patients with mild dementia((42.1?21.3),(55.0?29.0) ?mol/L) than those with moderate or severe dementia ((25.4?9.2) ?mol/L,P=0.023;(34.6?11.1) ?mol/L,P=0.036). Conclusion EAAs,correlating with the severity of the condition,play a significant role in AD,while aMCI patients also have disturbance of metabolism of EAAs,indicating that it has similar pathogenesis to AD.
4.Study of Stomach Using Ferric Oxide Suspension as Oral Contrast Agent in MRI
Jian YAO ; Weiling GUI ; Liguang CHEN ; Bin ZHAO
Journal of Practical Radiology 2001;0(01):-
Objective To evaluate the applied value superparamagnetic Ferric Oxide oral contrast agent in the dignosis of MR forstomach.Methods Ferric Oxide Suspension was administered before MR scanning of stomach in 36 cases,ranged in age form 21 to 60 years old.MR findings were analysed.Results The fullness of stomach was 100% after administration of Ferric Oxide Suspension.Stomach canal appeared as negative contrast in all MR sequences,the relation between lesions in stomach and around tissue were clearly showed.During MRCP,it could restrict the high signal in stomach canal.Conclusion Oral Ferric Oxide Suspension as contrast agent during MR examination of stomach is easily accepted by patients,it is a safe and steady negative contrast agent for gastrointestinal MR examination.
5.Peer-assisted learning combined with micro-teaching for international undergraduates during anesthesia internship
Binbin ZHU ; Jian SUN ; Rui ZHANG ; Yu GUI
Chinese Journal of Medical Education Research 2016;15(8):820-823
Objective To explore the peer assisted learning approach combined with micro-teaching in anesthesia internship for oversea students.Methods 60 international medical students were randomly divided into two groups.Students in the control group have peer guidance before routine theatre observation,while students in experimental group discuss micro-teaching of anesthetic skills with each other by watching real time videos from smart phone.Students' subjective attitudes to new approach were evaluated and their final exam score were analyzed.SPSS 1 1.0 was used for data processing and the data was made descriptive analysis,t test and analysis of variance.Results Students in experimental group did better in both theory exam (46.8 ± 4.03) vs.(35.7 ±6.12) and practice exam (35.2 ± 3.20) vs.(27.6± 4.71) than those in control group,and the total scores of two groups were (80.5 ± 7.40) and (63.1 ± 6.81) respectively.These scores all had significant difference between two groups.More students from experimental group than those from control group feel interested in anesthesiology (P<0.01) and feel confident about exams (P<0.05);There was no difference between two groups in understanding clinical guideline (P=0.57).Conclusion Peer assisted learning combined with micro-teaching is proved to enhance the quality of anesthesia teaching during internship for oversea undergraduates.
6.Transartenal chemoembolization and portal vein chemotherapy for hepatocellular carcinoma with portal vein tumor thrombosis
Jian WANG ; Fare SUN ; Yunlong GUI ; Qiang LI
Chinese Journal of General Surgery 1993;0(01):-
Objective To explore the efficacy of postoperative transarterial chemoembolization (TACE) and portal vein chemotherapy (PVC) for hepatocellular carcinoma (HCC) patients complicated with portal vein tumor thrombus (PVTT). Methods One hundred and eleven HCC patients with PVTT were randomly divided into three groups receiving respectively tumor resection only ( group A) , resection plus TACE ( group B) , and resection plus TACE and PVC ( group C). Results (1) Group B had significantly lower recurrence rates at 0. 5- and 1-year, and higher survival rates at 0. 5-year compared with group A (P
8.Determination of soluble compounds of barium in the air of workplace by ICP-AES.
Gui-hua LIU ; Wei CHEN ; Jian-bin XIE ; Wei ZHAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(1):78-79
Air Pollution
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analysis
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Barium
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analysis
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chemistry
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Solubility
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Spectrophotometry, Atomic
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methods
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Workplace
10.Questionnaires analysis of the rheumatologists' ability of reading sacroiliac joint's magnetic resonance imaging of spondyloarthritis
Zheng ZHAO ; Gui LUO ; Yanyan WANG ; Jian ZHU ; Feng HUANG
Chinese Journal of Rheumatology 2014;18(5):332-335
Objective To analyze the ability of rheumatologistto read the magnetic resonance imag of sacroiliac joint of spondyloarthritis patients.Methods The questionnaire survey were conducted among rheumatologists and the answers of the questionnaires were analyzed by quantitative analysis.Results 66.9% (75/112) rheumatologist did not known how to choose the sequence of magnetic resonance imaging,and 55.4%(62/112) rheumatologist thought that bone marrow edema was very important for the diagnosis of spondyloarthritis,but only less than 10% rheumatologists thought that erosion and fat infiltration could also h elp to make the diagnosis of spondy-loarthritis.Conclusion It is very important for rheumatologists to receive training on the reading of magnetic resonance images of sacroiliac joint of spondyloarthritis patients.