1.On Teaching Reformation of Advanced Studying Doctors Specialized in Obstetrics and Gynecology
Chinese Journal of Medical Education Research 2006;0(12):-
Aiming at some problems existing in the cultivation of advanced studying doctors,we think that strict selection should be made to guide advanced studying doctors to have correct understanding of their specialty and systemic training to improve the training quality.
2.Discussion of the intervention of social work in hospice
Chinese Journal of Hospital Administration 1996;0(01):-
With the development of the human society, people have come to pay more and more attention not only to their life quality but also to the quality of their life before death. Hence the emergence of hospice. At present there are three types of hospice in China: the family type, the general hospital type, and the special institution type. Each of these types has its own shortcomings. Hence the need for social work to intervene in hospice. The paper discusses the viability and necessity of the intervention through the notion, channels and methods of intervention. The role of social workers in hospice is also discussed.
6.Progress in the study of Her2-targeted cancer therapeutic antibodies.
Liang CHANG ; Chen-hui LI ; Jian GAO
Acta Pharmaceutica Sinica 2015;50(5):516-520
Tumor surface antigen human epidermal growth factor receptor 2 (Her2) is a type I receptor tyrosine kinase, which belongs to human epidermal growth factor receptor family. Her2-overexpression is associated with tumorigenesis and metastasis. Due to significant clinical effects, Her2-targeted cancer therapy especially therapeutic antibody has become the hot spot in the field of cancer treatment. Anti-Her2 antibody drugs include monoclonal antibodies, antibody-drug conjugates, bispecific antibodies and emerging "two in one" antibody. Based on structure and function of Her2, this review focuses on recent advances in active mechanisms and clinical researches of these antibodies.
Antibodies, Bispecific
;
therapeutic use
;
Antibodies, Monoclonal
;
therapeutic use
;
Humans
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Immunoconjugates
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therapeutic use
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Neoplasms
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drug therapy
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Receptor, ErbB-2
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immunology
7.Determination of alliin in mice plasma by HPLC
Junmin CHANG ; Jian CHEN ; Lijing ZHANG ;
Chinese Traditional Patent Medicine 1992;0(03):-
Objective: To develop HPLC method for determination of alliin concentration in mice plasma. Methods: The plasma samples were extracted with methanol. The analysis involved a ODS 1 column as stationary phase and distilled water as mobile phase. The flow rate was 0.5mL?min -1 , UV detection wavelength was at 220nm. 5 Fu was used as the internal standard. Results: The calibration curve was linear over a range from 14.8?g?mL -1 to 148.1?g?mL -1 with a correlation coefficient of 0.9992. Conclusion: The method is economic, simple, sensitive and accurate.
8.A Study on Medical Equipment Numbering Based on the Queueing Theory
Chinese Medical Equipment Journal 2004;0(09):-
Numbering quantities of medical equipment is studied based on Queueing Theory, which can provide a useful and applicable tool for study on medical equipment numbering.
9.An investigation of risk factors of wound complications after operative fixation for calcaneal fractures
Jian ZOU ; Wei ZHANG ; Chang-Qing ZHANG ;
Chinese Journal of Orthopaedic Trauma 2004;0(07):-
Objective To explore the risk factors contributing to wound complications following operative fixation for fractured calcanea.Methods Fitly-six patients with 61 fractured calcanea who had been treated with operative fixation from March 2000 to March 2003 were enrolled in investigation.General information of the pa- tients,ages,injury causes,classification of fracture,fall heights,smoking,delayed operation time,operation time and tourniquet time were documented preoperatively and postoperatively to be analyzed statistically.Results We report an overall wound complication rate of 14.8%(9/61).Wound infection,haematoma,dehiscence,heel necrosis and osteomyelitis were noted in our series.We identified the following as risk factors of postoperative wound compli- cations:1)fall from more than 3.4 m high(P<0.05);2)delayed operation time less than seven days(P<0.05); 3)operating time beyond two hours(P<0.05);4)tourniquet time beyond 1.5 hours(P<0.05).Conclusion In order to decrease wound complications following operative fixation tor fractured calcanea,surgeons should pertorm the operation 7 to 10 days after the injury,and reduce the operation time and tourniquet time.
10.Progress in the study of Her2-targeted cancer therapeutic antibodies.
Liang CHANG ; Chenhui LI ; Jian GAO
Acta Pharmaceutica Sinica 2015;50(5):516-20
Tumor surface antigen human epidermal growth factor receptor 2 (Her2) is a type I receptor tyrosine kinase, which belongs to human epidermal growth factor receptor family. Her2-overexpression is associated with tumorigenesis and metastasis. Due to significant clinical effects, Her2-targeted cancer therapy especially therapeutic antibody has become the hot spot in the field of cancer treatment. Anti-Her2 antibody drugs include monoclonal antibodies, antibody-drug conjugates, bispecific antibodies and emerging "two in one" antibody. Based on structure and function of Her2, this review focuses on recent advances in active mechanisms and clinical researches of these antibodies.