Adult ; Aged ; Digoxin ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Heart Failure ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy

S100A7 protein has a variety of functions,concerning with multiple basic biological processes of cells such as proliferation,differentiation,apoptosis,signal transduction,lipid metabolism,adherence and migration.It is expressed mainly in the inflammatory diseases and tumors,and strongly correlated with metastasis of some tumors.

Replacement therapy of stem cells transplantation represents a potential treatment for neural retinal diseases.Despite the encouraging results in laboratory,the clinical application of cells replacement therapy is still difficult because the limitation of seed cells,immunologic rejection,oncogenicity and ethical problems,etc.Recent breakthrough in somatic reprogramming provides a promising solution overcoming these obstacles.Further researches on virus-free reprogramming will make the clinical application of stem cell replacement therapy possible.

This article mainly discusses the relationship between the active treatment concept of the systemic lupus erythematosus (SLE) and its positive outcome in long-term prognosis,which is the overall prognosis of SLE benefits from the improvement on the liying conditions of patients with lupus nephritis (LN).Although more argumentations are still required in regards to whether to use the different general conclusions of the meta analysis between the childhood-onset SLE (cSLE) and the early adulthood-onset SLE patients at the same age as more proactive induction therapy in early phase,yet the time point for early therapy before clinical symptoms appearing can be determined and thereby positive anticipation can be achieved through keeping the difference between the long-term prognosis of the cSLE and the adult-onset patients as evidences,and making in-depth study on the innate laws of the heterogeneity of cSLE,meanwhile giving biological markers more application which can be highly reliable in reflecting the morbid status,supported by the study outcomes of pharmacogenetics/pharmacogenomics and further optimization of current immunoregulation/immune inhibitors approaches (as evidences required by long-term effects).

Objective To detect the serum allergen specific IgE in the children patients with allergic diseases to provide the basis for the clinical diagnosis,treatment and prevention of allergic diseases.Methods To detect the allergen specific IgE in 248 children patients(aged 8 months to 14 years old)with allergic diseases by the EUROLINE method.The detection results were statistically analyzed.Results Among 248 cases,allergic rhinitis(AR)and bronchial asthma were dominated by the inhalant allergens,in which the house dust mites/dust mites had the highest positive rate (86.9%),followed by roach(45.3%);urticaria and allergic purpura were dominated by food allergens,in which crab had the highest positive rate (43.2%),followed by marine fish(31.4%).Conclu-sion The house dust mites/dust mites in the inhalant allergens and crab and marine fish in the food allergens are the main allegens in Luzhou area,the children patients with allergic diseases should avoid to contact or intake the allergen in order to reduce the oc-curence of allergic disease.

Objective To study the effect of operation after neoadjuvant chemotherapy on gastric cancer patients with Ⅲ,Ⅳ grade.Methods 120 gastric cancer patients with Ⅲ,Ⅳ grade were selected.52 cases in the control group were given routine operation,68 cases in the observation group received neoadjuvant chemotherapy plus operation treatment.The operation resection rate,solid tumor progress assessment and postoperative recurrence rate in three months,six months and one year were observed.Results The radical resection of the observation group was 62.24％ (43/68),which was significantly higher than that of the control group 46.15％ (24/52) (x2 =5.81,P ＜0.05).The palliative resection and laparotomy of observation group were 20.59％ (14/68) and 16.18％ (11/68),which were significantly lower than those of the control group (x2 =4.04,4.92,all P ＜ 0.05).Tumor remission of the observation group was 61.76％ (43/68),which was significantly higher than that of the control group 50％ (26/52)(P ＜ 0.05).The tumor progress of the observation group was 17.65％ (12/68),which was significantly lower than that of the control group 28.85％ (15/52) (x2 =4.17,P ＜ 0.05).The tumor recurrence rates in 3 months and 6 months of the observation group were 10.29％ (7/68) and 17.65％ (12/68),which were significantly lower than those of the control group (x2 =4.61,P ＜ 0.05).Conclusion Neoadjuvant chemotherapy before operation can improve the operation resection rate,reduce the relapse rate,delay the recurrence and metastasis of gastric cancer,improve the prognosis of the patients.

Treatment based on syndrome differentiation, as a core of diagnostic and treatment methods in traditional Chinese medicine, now appears to be limited by some of its shortages during the high-speed development of medicine, such as no symptoms for differentiation in some patients, lack of objective standardization and pertinence, and limitations of the four diagnostic methods, etc. Combination of syndrome differentiation and disease differentiation can not only make up the shortages of syndrome differentiation but also expand the scope of diseases treated with traditional Chinese medicine and promote the modernization of traditional Chinese medicine. The author discusses the limitations of treatment based on syndrome differentiation as well as the advantages of combining syndrome differentiation with disease differentiation. It is also stated that this combination can make the system of syndrome differentiation perfect.

Nine cases of urinary tract infection with different clinical symptoms were treated with basically the same or different Chinese herbal drugs, and the effects were identified according to the improvement of their symptoms and urinary tests. The problems existing in clinical practice of traditional Chinese medicine were considered and discussed by analyzing and comparing the similarities and differences of syndrome differentiation treatment of the 9 cases.

Fibrin related markers include several proteins and fragments developed in the conversion of fibrinogen to cross-linked fibrin and following degradation.FDP played as a more important role than conventional global coagulation test before application of D-dimer in clinical settings,moreover,combination of FDP and D-dimer improve the diagnostic of DIC greatly,and D-dimer has become an effective tool excluding venous thromboembolism besides the imaging.Whether basic or clinical research on soluble fibrin monomers and complexes were focused in an early stage,however,limited by diversity of analytes and nonstandardization,no full application was come into being.It is worthwhile to note that fibrin related markers release into plasma sequentially from initialization of fibrinogen activation to fibrinolysis.Thus,the combination of these index is useful to understand patient's condition (such as DIC),prognosis of VTE recurrence,and prophylaxes of post-operation thrombosis.