[Aim]To establish an HPLC method for determination of geniposide in Jieyu'anshen Granule Liquid.[Methods]A shimpack C18 column was used.The mobile phase was Acetonirile-water(15:85).The detection wavelength was 238nm.[Results]The linear range of geniposide was 0.0375~0.2250ug,r=0.9999(n=6).The average recovery was 98.67%.[Conclusion]This method is convenient,rapid and accurate.It can be for quality control in Jieyu'anshen Granules Oral Liquid.