Objective To investigate the correlation between TyG index,LDL/ApoB and type 2 diabetic nephropathy (DN),and to explore the predictive value of the both and their combined application in type 2 di-abetic nephropathy.Methods A total of 160 inpatients with type 2 diabetes mellitus (T2DM) in the endocri-nology department of this hospital from October 2021 to September 2023 were collected and divided into the three groups based on the urinary albumin-to-creatinine ratio (UACR):simple diabetes group (UACR<30 mg/g,78 cases),early diabetic nephropathy group (UACR 30-<300 mg/g,45 cases) and middle stage dia-betic nephropathy group (UACR≥300 mg/g,37 cases).The differences in the general clinical data,biochemi-cal indicators and LDL/ApoB and TyG index were compared among the three groups.In addition,the patients were divided into the non-diabetic nephropathy group (UACR<30 mg/g,78 cases) and diabetic nephropathy group (UACR≥30 mg/g,82 cases).The predictive value of TyG index and LDL/ApoB to diabetic nephropa-thy was analyzed.Results The disease duration,HbA1c,TC,TG,HDL,ApoB,creatinine,estimated glomeru-lar filtration rate (eGFR),LDL/ApoB and TyG index had statistical differences among the three groups (P<0.05).The TyG level in the simple diabetic group,early diabetic nephropathy group and middle stage diabetic nephropathy group was decreased successively,and the differences among the three groups had statistical sig-nificant (P<0.05).The level of LDL/ApoB in the middle stage diabetic nephropathy group and early stage diabetic nephropathy group was lower than that in the simple diabetic group,and the difference was statistical-ly significant (P<0.05).The LDL/ApoB level had no statistical difference between the middle stage diabetic group and early stage diabetic nephropathy group (P>0.05).The area under the receiver operating character-istic (ROC) curve (AUC) of TyG index for predicting diabetic nephropathy was 0.759,which of LDL/ApoB for predicting diabetic nephropathy was 0.701,and which of the two indexes combination for predicting dia-betic nephropathy was 0.824.Conclusion LDL/ApoB and TyG index all could serve as the predictive indica-tors for type 2 diabetic nephropathy,and their combination has more predictive value for diabetic nephropa-thy.